Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:P02794 (ferritin)
 17,525 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The mechanism of tumor localization of gallium-67 (67Ga) is not known with certainty, although much information has been derived regarding the biodistribution and subcellular fate of 67Ga in a variety of tumors and other tissues from experimental animals. After intravenous administration, 67Ga is bound to transferrin in the blood, and distributed to liver, lacrimal glands, salivary glands, and soft tissue tumors. Within the cells of the liver and tumors, gallium is found in lysosomes, and rough endoplasmic reticulum. Within these organelles, 67Ga is bound to a variety of macromolecules, including transferrin, ferritin, and a 45,000 molecular weight glycoprotein. Recent studies of tumor cells growing in tissue culture suggest an important role for transferrin in 67Ga tumor uptake. This uptake is mediated by a transferrin specific cellular receptor.
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PMID:Mechanisms of localization of gallium-67 in tumors. 21 49

The pathway taken by membrane that is recovered by endocytosis from the surface of secretory cells was investigated with electron-dense tracers 9dextrans and cationized ferritin). The cell types examined included exocrine cells of the parotid and lacrimal glands, endocrine cells of the anterior pituitary gland, and immunoglobulin-secreting cells from lymph nodes or myeloma cell lines. In all cases, when the cells were incubated at 37 degrees C the tracers were initially taken up by endocytosis and they later appeared in the stacked Golgi cisternae, in immature secretion granules or vacuoles and in lysosomes. Similar results were obtained after covalent labelling of surface membrane constituents when myeloma cells were radioiodinated and the fate of the labelled components was followed by autoradiography. Initially only the cell surface was labelled, and the autoradiographic grains were concentrated over the plasmalemma. After incubation at 37 degrees C some of the labelled components were internalized (by endocytosis), and the majority of the internal autoradiographic grains were found over Golgi cisternae and over associated secretory vacuoles, which were the only organelles significantly labelled. The findings indicate the existence of considerable membrane traffic from the plasmalemma to the stacked Golgi cisternae and forming secretion granules or vacuoles in all these cell types. Membrane is thus continually recovered from the cell surface of secretory cells and funnelled through the Golgi complex; moreover, the plasmalemma-to-Golgi traffic appears to represent a major route of membrane traffic in secretory cells. A large portion of this traffic appears to be associated with the recycling of the membrane containers used in the packaging of secretory products.
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PMID:Membrane recycling in secretory cells: pathway to the Golgi complex. 618 82

Orbital inflammation has been rarely associated with adult-onset Still's disease (AOSD). We herein describe two AOSD patients who developed lacrimal gland enlargement with inflammation spreading to the contiguous tissues in the orbit. Case 1 was a 26-year-old woman who developed bilateral eyelid swelling while taking prednisolone (22.5 mg/day) for AOSD. The swelling of the eyelid worsened after other symptoms emerged, such as a fever, a rash, and arthritis. The laboratory findings, including leukocytosis, liver dysfunction, and ferritin elevation, also suggested an AOSD flare-up. Case 2 was a 62-year-old woman who presented with left eyelid swelling. She was diagnosed with AOSD at 45 years of age but sustained remission. During admission, she subsequently developed a fever, a rash, arthritis, lymphadenopathy, and ocular hyperemia. AOSD was suspected from the clinical course. We speculate that dacryoadenitis and orbital inflammation are manifestations of AOSD.
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PMID:Two cases of adult-onset Still's disease with orbital inflammatory lesions originating from the lacrimal gland. 2752 23