Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UNIPROT:P02794 (
ferritin
)
17,525
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
We have devised a complementation assay in yeast to clone mammalian transcriptional activators and have used it to identify a human
basic leucine-zipper transcription factor
that we have designated Nrf1 for
NF-E2-related factor 1
. Nrf1 potentially encodes a 742-aa protein and displays marked homology to the mouse and human NF-E2 transcription factors. Nrf1 activates transcription via NF-E2 binding sites in yeast cells. The ubiquitous expression pattern of Nrf1 and the range of promoters containing the NF-E2 binding motif suggest that this gene may play a role in the regulation of heme synthesis and
ferritin
genes.
...
PMID:Cloning of Nrf1, an NF-E2-related transcription factor, by genetic selection in yeast. 824 56
