Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UNIPROT:P02794 (
ferritin
)
17,525
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The effect of the key iron homeostasis proteins transferrin and
ferritin
on the activity of partially purified brain calcium-calmodulin-dependent phosphodiesterase (
CaM-PDE
, EC 3.4.1.17) were studied. Transferrin and
ferritin
were found to be potent natural activators of
CaM-PDE
. The key factor determining the degree of activation by these proteins is their saturation with iron: apotransferrin activated
CaM-PDE
6-7-fold; iron-poor brain
ferritin
and liver
apoferritin
(taken for comparison) activated the enzyme 4-5- and 2-fold, respectively. Diferric transferrin and iron-rich liver
ferritin
had no effects on the enzyme activity. Transferrin and
ferritin
(both in apo- and iron-saturated forms) did not change the activity of calmodulin-phosphodiesterase complex. The data suggest that apotransferrin and iron-poor transferrin are involved in the regulation of cyclic nucleotide content in nervous tissue.
...
PMID:Transferrin and ferritin modulate the activity of brain calcium-calmodulin-dependent phosphodiesterase. 915 70
