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Query: UNIPROT:P02794 (ferritin)
 17,525 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Polycationic ferritin (PCF) was injected into umbilical veins of 17- and 21-day-gestation rats and saphenous veins of young, male, adult Sprague-Dawley rats and allowed to circulate for 1 min or less followed by excision of tissues and immersion fixation. Fetal liver, intestine, and kidney, as well as adult liver, intestine, pancreas, kidney, adrenal cortex, bone marrow, and pituitary were examined. Nearly all fenestral diaphragms, but no subendothelial structures, were labeled with a tuft of particles in fetal intestine, adult intestine, pancreas, pituitary, and renal peritubular capillaries. A fraction of the diaphragms covering fenestrae in the thyroid, adrenal cortex, and fetal kidney glomerulus, but none in the bone marrow and fetal liver, had associated PCF. In these tissues some diaphragms appeared to be permeable to PCF, because tufts were observed immediately beneath unlabeled fenestral diaphragms either in the basal lamina (fetal kidney, adult thyroid, and adrenal cortex) or on other subendothelial structures (fetal liver, adult bone marrow). Also periodic concentrations of PCF were observed in the lamina rara interna of the adult glomerular basement membrane. PCF binding to the fenestral diaphragms and the basal lamina in the adult intestine and the renal glomerulus, respectively, have been reported by Simionescu et al. ((1981a) J. Cell. Biol. 90, 605-613) and Kanwar and Farquhar ((1979) J. Cell. Biol. 81, 137-153) as indicating accumulations of anionic material. In this study we have demonstrated not only high-specificity binding of PCF to fenestral diaphragms in capillaries of organs other than intestine and pancreas, but also considerable variation of PCF stainability of fenestral diaphragms in other organs.
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PMID:A survey of the binding of polycationic ferritin in several fenestrated capillary beds: indication of heterogeneity in the luminal glycocalyx of fenestral diaphragms. 688 86

Developmental processes of the fetal rat kidney from uninephrectomized mothers were studied. The uninephrectomy was performed on day 5 of gestation. Glomerular number and volume in the fetal kidneys on days 18, 20, and 22 of gestation were morphometrically determined. To investigate the anionic site formation in the glomerular basement membrane, distribution of cationized ferritin (CF) in the fetal glomerulus was examined electron microscopically after CF injection. Blood urea nitrogen (BUN) concentration in the pregnant rats was also determined on various days after uninephrectomy. On fetal days 20 and 22, the glomerular volume was significantly larger in the fetuses from uninephrectomized mothers than in those from sham-operated ones. On fetal day 20, the CF particles were clustered in the laminae rarae interna and externa of the glomerular basement membrane in the fetuses from uninephrectomized mothers, while the clusters were arrayed in three to four layers in the glomerular basement membrane in the fetuses from sham-operated ones. On fetal day 22, the CF particles noted in the lamina rara externa in the fetuses from uninephrectomized mothers were slightly larger in number than such particles in the age-matched control fetuses. The BUN concentration of the uninephrectomized pregnant rats was significantly higher than that of the sham-operated pregnant ones on each postoperative day. These results suggest that the development of the fetal renal glomerulus is accelerated by the elevated BUN level following maternal uninephrectomy when the fetal kidney is functional in effective filtration in the rat.
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PMID:Effects of maternal uninephrectomy on the development of fetal rat kidney: numerical and volumetric changes of the glomerulus and formation of the anionic site in the glomerular basement membrane. 983 57

Human placental isoferritin is composed of a 43 kDa subunit and ferritin light chains. It acts as an immunosuppressive cytokine in normal gestation and in some malignant conditions. We investigated p43-placental isoferritin expression at the maternal fetal tissue interface and in fetal kidneys in Down's syndrome (DS) compared with normal control samples. Following termination of mid-gestation pregnancies placental and fetal kidney tissue samples were collected. Immunohistochemical analysis of the specimens was performed using a monoclonal antibody generated against human p43-placental isoferritin protein (CM-H-9 mAb). Expression of p43-placental isoferritin was detected in Hofbauer cells and in the syncytial layer of placental tissue. Significantly higher numbers of positive Hofbauer cells were detected in DS placentae at 17 weeks gestation compared with the controls. The number of immunopositive Hofbauer cells decreased in DS placentae at 20 weeks gestation, 3 weeks later than in controls. In kidneys of fetuses at 17 weeks gestation, p43-placental isoferritin immunoreactivity was confined to the proximal tubules of the nephrons. DS kidneys had higher staining intensities compared with similar gestational age controls. Enhanced expression of p43-placental isoferritin was observed in DS placentae and fetal kidneys. This may explain the increased p43-placental isoferritin levels in the maternal serum of DS gestations.
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PMID:Enhanced expression of the immunoregulator, p43-placental isoferritin, in Down's syndrome placentae and fetal kidneys. 1246 46