Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:P02794 (ferritin)
 17,525 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

In the introduction the author explains the term marker and its synthesis. Demands on markers are as follows: 1. strict specificity, 2. correlation with the clinical stage, 3. prognostic information. The authors discusses in more detail the problem of human choriogonadotropin, alpha-fetoprotein, basic fetoprotein and specific beta-1-glycoprotein in germinal testicular tumours. The author mentions placental alkaline phosphatase, ferritin, lactic dehydrogenase in the above tumours, in carcinoma of the prostate prostatic specific antigen, in carcinoma of the bladder oncofoetal antigens.
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PMID:[Introduction to the problem of markers in urologic oncology]. 213 39

We report four patients with pineal germinoma in whom the initial procedure for obtaining a tissue diagnosis was a stereotaxic biopsy. In all four cases, the biopsy showed granulomatous inflammation with epithelioid cells and lymphocytes. In one case, the granulomatous inflammation was accompanied by classical germinoma. Another case exhibited malignant cells considered nondiagnostic for a specific neoplasm. Two cases had no evidence of a malignant tumor; they were composed entirely of granulomatous inflammation. In two of the three cases where the diagnosis was not established by the first biopsy, a second stereotaxic biopsy showed pineal germinoma. Tissue obtained at resection in the third patient revealed large areas of granulomatous inflammation accompanying the germinoma. Immunoperoxidase stains for ferritin and placental alkaline phosphatase did not increase diagnostic yield. We conclude that a finding of granulomatous inflammation in a stereotaxic biopsy specimen of a pineal mass should suggest a diagnosis of germinoma, followed by sampling from several different target points within the lesion.
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PMID:Granulomatous inflammation in pineal germinoma. A cause of diagnostic failure at stereotaxic brain biopsy. 304 94

A trophoblast-like cell line, TL, was established from a normal-term human placenta. The TL cells were epithelial in morphology with relatively large vesicular nuclei, prominent nucleoli, and numerous microvilli on the cell surface. Cytoplasmic organelles were generally sparse but mitochondria and polysomes were abundant. The cells grew as compact sheets with close membrane approximation interconnected occasionally by desmosome-like junctions. TL cells contained placental alkaline phosphatase, a placenta-associated antigen, cytokeratin, and prekeratin, but not keratin. In parallel, they were negative for factor VIII, vimentin, and fibronectin. Population doubling time was estimated to be about 34 h. TL cells were tumorigenic in nude mice and an increase in tumorigenicity was observed after a certain number of passages in vitro. Chromosome analysis revealed that TL cells were highly heterogenous and had a female aneuploid karyotype with a hypotriploid mode. Unlike trophoblastic cell lines established from neoplastic tissues, TL cells did not synthesize human chorionic gonadotropin or other gonadal hormones, and only a small amount of ferritin (40.3 ng/10(6) cells) could be detected in the cell supernatant and cell extract. Based on various morphological and histochemical criteria, we suggest that the TL cells are derived from the Langhans cells (villous cytotrophoblast), and due to their special features, the cells may be valuable for the study of the differentiation and tumorigenesis of trophoblastic cells.
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PMID:Establishment and characterization of a tumorigenic trophoblast-like cell line from a human placenta. 358 Oct 66

Immunohistological studies on frozen sections of human placentae and breast carcinoma tissue using heteroantisera raised against both trophoblast microvillous plasma membrane preparations isolated from normal placentae and irradiated MCF-7 breast carcinoma cells have demonstrated a cell membrane antigen expressed by both normal human trophoblast and human breast carcinoma cells. The heteroantisera used in this study had all been previously adsorbed with immobilized human term pregnancy serum, placental alkaline phosphatase and placental ferritin preparations, as well as with human peripheral blood leucocytes. The oncoplacental membrane antigen would appear not to be represented in other normal tissues, but is represented on Jar choriocarcinoma cells and to a lesser degree on AV3 amniotic cells. Adsorption experiments have demonstrated that this antigen may not be dominant within the range of antigenic specificities of heteroantisera raised against MCF-7 cells or isolated trophoblast microvillous plasma membrane preparations.
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PMID:A cell membrane antigen expressed by both human breast carcinoma cells and normal human trophoblast. 616 65

The cells in intratubular germ cell neoplasia in the vicinity of 38 germ cell tumors of the testis, including 20 pure seminomas, were studied for the expression of beta 2-microglobulin (beta 2m), the constant component of all HLA class I molecules. Immunohistochemistry using antibodies towards beta 2m, vimentin, placental alkaline phosphatase, and ferritin was employed. Whereas the intratubular cells in normal testis are beta 2m negative, beta 2m positive cells were identified in intratubular germ cell neoplasia tubules in 55 per cent of all tumors and in 60 per cent of the seminomas. The tubules with beta 2m positive cells were located in areas with invasive tumor or in the vicinity of such areas. The beta 2m positive cells were identified as Sertoli cells by morphology and by their staining with anti-vimentin. Neoplastic germ cells, identified by morphology and staining with anti-placental alkaline phosphatase and anti-ferritin were beta 2-microglobulin negative. The most intensely beta 2m-stained Sertoli cells were found in tubules with high concentrations of neoplastic germ cells. Intensely stained Sertoli cells were also found in 'Sertoli cell only' tubules inside invasive tumors and in areas without lymphocytic infiltration. The cells in adjacent normal tubules were beta 2m negative.
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PMID:Sertoli cells of intratubular germ cell neoplasia express beta 2 microglobulin. 757 71

The examination of 150 patients with pleural exudate of different origin (43 cases of malignant and 107 cases of benign genesis) was made to elucidate diagnostic value of immunochemical serum and pleural fluid estimation of four tumor-associated proteins: carcinoembryonic antigen (CEA), beta 2-microglobulin (beta 2-MG), placental alkaline phosphatase (PAP), ferritin; three acute-phase proteins: C-reactive protein (CRP), lactoferrin, fibrin degradation products (FDP); expression of epithelial membrane antigen (EMA) in e date cells using monoclonal antibodies ICO-25. Determination CEA, beta 2-MG in the serum and pleural fluid, antituberculous an bodies in biological fluids proved diagnostically valuable for verification of pleural exudate characteristics. The discriminant analysis provided formulas for this differential diagnosis. The method identification in pleural fluid of cells expressing EMA with the use of monoclonal antibodies ICO-25 was found to be 2 times more efficient in detection of cancer cells than the standard light microscopy.
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PMID:[Tumor-associated and acute-phase proteins in the diagnosis of cancerous exudative pleurisy]. 902 37