Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:P02794 (ferritin)
 17,525 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The subjects for this study were 24 female, well-trained distance runners and 41 sedentary, female university students. On the basis of haematological measurements, the subjects were divided into four groups: a group with iron deficiency, non-anemic (normal haemoglobin and red cell count but serum ferritin less than 20 micrograms degrees 1-1) runners (IDR, n = 11), a group of runners with normal iron status (NR, n = 13), a group of sedentary women with normal iron status (NC, n = 26) and a group of iron deficient, non-anemic sedentary subjects (IDC, n = 15). Maximal oxygen uptake (VO2max) and lactate thresholds were determined during incremental bicycle ergometer exercise testing and on separate occasions the ratings of perceived exertion (RPE) were assessed at 25, 50, 75 and 90% VO2max using Borg's scale. There were no differences in the relationship between RPE and work load groups of runners or sedentary subjects with normal and deficient iron status. Iron deficiency did not affect VO2max and lactate thresholds. However, low body iron stores (serum ferritin level below 20 micrograms degrees 1-1) without overt anemia was associated with increased venous blood lactate concentration after maximal exercise load. This study demonstrated that physical work capacity and RPE were not affected by iron deficiency without anemia either in trained or untrained women.
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PMID:The relationship between iron status and perceived exertion in trained and untrained women. 812 89

Giant cell arteritis (GCA) is considered to be a T cell-dependent disease. Autoantibodies have not consistently been found in GCA. The exception is antiphospholipid antibodies (APLA), which were found in 30-80% of GCA cases. Recently, efforts have been made to seek autoantibodies in GCA using newer methods of detection: serological identification of antigens by recombinant cDNA expression cloning, and a proteomic approach. In these studies, lamin C (a nuclear envelope antigen) was recognized by antibodies in 32% of GCA sera and none of the controls. Other autoantigenic proteins were also identified: lamin A, vinculin (a cytoskeleton antigen), and annexin 5 (an endothelial protein). In a recent study, 92% of 36 patients with GCA and/or polymyalgia rheumatica (PMR) had autoantibodies to a human ferritin peptide (the heavy chain N-terminal); 89% had antibodies to bacterial ferritin peptide of Staphylococcus epidermidis. The significance of these findings needs to be studied further. GCA may be a part of the newly described ASIA syndrome (autoimmune syndrome induced by adjuvants). A recent study from Italy reported 10 cases of GCA/PMR within 3 months of influenza vaccination. These comprised 50% of all cases of GCA/PMR diagnosed during the 6 year period of the study. Another 11 cases of GCA following influenza vaccinations were reported. GCA pathogenesis involves all branches of the immune system, including antigen-presenting cells, T cells and B cells, and autoantibody formation is not uncommon. GCA etiology remains unknown, but may be associated with exposure to bacterial or viral antigens.
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PMID:Autoimmune aspects of giant cell arteritis. 2516 95

Iron (Fe) deficiency chlorosis (IDC) leads to leaf yellowing, stunted growth and drastic yield losses. Plants have been differentiated into 'Fe-efficient' (EF) if they resist to IDC and 'Fe-inefficient' (IN) if they do not, but the reasons for this contrasting efficiency remain elusive. We grew EF and IN soybean plants under Fe deficient and Fe sufficient conditions and evaluated if gene expression and the ability to partition Fe could be related to IDC efficiency. At an early growth stage, Fe-efficiency was associated with higher chlorophyll content, but Fe reductase activity was low under Fe-deficiency for EF and IN plants. The removal of the unifoliate leaves alleviated IDC symptoms, increased shoot:root ratio, and trifoliate leaf area. EF plants were able to translocate Fe to the aboveground plant organs, whereas the IN plants accumulated more Fe in the roots. FRO2-like gene expression was low in the roots; IRT1-like expression was higher in the shoots; and ferritin was highly expressed in the roots of the IN plants. The efficiency trait is linked to Fe partitioning and the up-regulation of Fe-storage related genes could interfere with this key process. This work provides new insights into the importance of mineral partitioning among different plant organs at an early growth stage.
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PMID:Iron partitioning at an early growth stage impacts iron deficiency responses in soybean plants (Glycine max L.). 2602 27