Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UNIPROT:P02794 (
ferritin
)
17,525
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Identification of
pre-B-cell colony-enhancing factor
(
PBEF
) interacting partners may reveal new molecular mechanisms of
PBEF
in the pathogenesis of acute lung injury (ALI). The interactions between
PBEF
and NADH dehydrogenase subunit 1(ND1), ferritin light chain and interferon induced transmembrane 3 (IFITM3) in human pulmonary vascular endothelial cells were identified and validated. ND1,
ferritin
and IFITM3 are involved in oxidative stress and inflammation. Overexpression of
PBEF
increased its interactions and intracellular oxidative stress, which can be attenuated by rotenone. The interaction modeling between
PBEF
and ND1 is consistent with the corresponding experimental finding. These interactions may underlie a novel role of
PBEF
in the pathogenesis of ALI.
...
PMID:Interactions between PBEF and oxidative stress proteins--a potential new mechanism underlying PBEF in the pathogenesis of acute lung injury. 1848 13
