Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:P02794 (ferritin)
 17,525 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The ferritin level in serum was investigated in 9 patients with myocardial infarction, all with a history of chest pain of less than 4 hours before admission. A significant rise in serum ferritin level was found in 8 patients. The rise was generally smaller than that seen in acute infection and not significantly correlated to the size of infarction, as estimated from changes in serum levels of myoglobin, ASAT and LDH. The rise started after a mean of 30 hours, the peak being reached within a week (M 4.3 days). Serum ferritin then fell to 120--300% (M 190) of the initial level, where it remained. An initial rise in serum iron levels was unexpectedly seen within 12 hours in 7 patients.
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PMID:Serum ferritin during inflammation. A study on myocardial infarction. 52 35

A 53-year-old woman was admitted to our hospital due to high fever, arthralgia and skin rash. Main laboratory data included the following: WBC 17,100/mm, GOT 58 U, GPT 47 U, LDH 1,510 U, ferritin 19,000 ng/ml, adenosine deaminase 79.1 U/l. She was diagnosed as having adult-onset Still's disease. Aspirin (3.0 g/day) and prednisolone (40 mg/day) were administered. All the symptoms and laboratory data improved rapidly. Adenosine deaminase, ferritin, and LDH are considered to originate mainly from the liver. Liver injury in this disease may be a primary lesion, and various serum markers may be associated with the liver abnormalities.
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PMID:Adult-onset Still's disease: hepatic involvement and various serum markers relating to the disease activity. 192 Sep 66

Chemical analysis of ascitic fluid may be helpful in determining the underlying disease. We discuss the diagnostic accuracy of the common and newer chemical parameters (protein, LDH, lactate, glucose, cholesterol, triglycerides, phospholipids, fibronectin, albumin gradient [value of serum minus value of ascites], ferritin, tumor markers, immunomodulators, leukocytes, bacterial and cytologic examinations). We also review the pathogenesis and clinical findings of the most frequent ascites forms (benign hepatic, infective, malignant ascites, ascites associated with liver metastases or hepatocellular carcinoma, cardiac and pancreatic ascites) and the most important diagnosis criteria. In the malignant ascites a high cholesterol, a narrow albumin gradient or a high ferritin value have high diagnostic accuracy, but diagnosis is by the finding of malignant cells. For the diagnosis of infective ascites, bacteriology is mandatory even though the results are negative in most cases, particularly in spontaneous bacterial peritonitis where diagnosis has to be established clinically, by a low pH or by a high leukocyte count. Benign hepatic ascites is diagnosed by demonstrating an underlying chronic liver disease and laboratory examinations of the peritoneal fluid to exclude other causes. The laboratory tests in ascites associated with liver metastases or with hepatocellular carcinoma were similar to those in benign hepatic ascites and the two ascites forms must be separated by other clinical and technical findings. Pancreatic ascites can easily be distinguished from the other forms by the high amylase and lipase content.
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PMID:[Laboratory chemical analysis in ascites]. 203 10

The authors reported on a three month long EPREX (human recombinant erythropoietin) therapy of 5 hemodialysis patients for the treatment of their anemia. The drug was administered in bolus form 2 or 3 times a week after dialysis in a dose of 50 to 150 IU/bodyweight increased gradually in every (or every second) week. Hgb ad Htk values were determined once a week while erythrocyte, leukocyte, thrombocyte and reticulocyte count once a month. Serum iron, TIBC, serum ferritin, BUN, serum creatinine, urea, serum ions, liver function assays, serum lipids and amylase were also established. Hgb, Htk levels and reticulocyte count have significantly increased in the 4th week of treatment already, severe anemia ceased with improved appetite, general condition and physical strength. Serum urea and LDH levels significantly increased while SGOT decreased. No significant change in leukocyte and thrombocyte count, serum Na, K, Ca, P, Cl, BUN, creatinine, total protein level, serum albumin, bilirubin, alkaline phosphatase, GGT, GPT, amylase and blood sugar as well as serum lipid level were observed. No adverse reactions occurred during the treatment. After the three gradually decreased and within 6 weeks they had to be transfused again. In three patients the need for transfusion has significantly grown after the treatment. The authors consider EPREX a highly efficient drug in the treatment of anemia in dialysis patients.
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PMID:[Recombinant human erythropoietin in the therapy of anemia in hemodialyzed patients]. 223 36

A 57-year-old man was admitted to our hospital with high fever and nasal obstruction. The diagnosis of T cell type malignant lymphoma (T-ML) was made by the biopsy of left nasal cavity tumor. After admission, his general condition was improved by chemotherapy and radiotherapy, but relapsed a month later. He was then treated with chemotherapy, and the partial remission was obtained. During the clinical course, he had a high fever again without any significant infections or exacerbation of T-ML. The data of coagulation system showed DIC. The levels of serum ferritin and LDH were extremely elevated. Bone marrow aspiration showed markedly increased hemophagocytic histiocytes. These data suggested that he was complicated by DIC and hyperferritinemia closely associated with hemophagocytic histiocytosis a part from the underlying T-ML. Causes of DIC and hyperferritinemia associated with hemophagocytic histiocytosis in the present case were discussed.
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PMID:[T-cell malignant lymphoma with hemophagocytic histiocytosis, hyperferritinemia and disseminated intravascular coagulation syndrome]. 228 69

Seven tumor markers (CA125, CA19-9, TPA, IAP, CEA, ferritin, LDH) were measured in 24 patients with ovarian cancer. The positive rates in untreated cases of ovarian cancer were 87.5% for CA125, 35.5% for CA19-9, 10% for CEA, 77.8% for IAP, 63.6% for TPA, 28.6% for LDH and 35.3% for ferritin. Among these, CA125 was the most available marker for detecting tumor growth or regression during each respective clinical course by serial measurement. Serial changes in serum alpha-fetoprotein (AFP) levels during treatment were studied among 27 patients with ovarian embryonal carcinoma. AFP decreased with a half-life of about 7 days, and was restored to the normal range within 10 weeks after the initial surgery and chemotherapy (VAC) in all cases. In subsequently fatal cases, AFP rose again during 10 to 30 weeks after the initial treatment.
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PMID:[Significance of tumor markers in the treatment of patients with ovarian malignancies]. 244 93

The object of this study was to determine the known laboratory parameters, tumor markers and immunomodulatory substances in 69 ascites of various etiology, and to test their diagnostic significance. The usual parameters such as protein content, LDH ratio, albumin quotient and albumin gradient, fibronectin, cholesterol and cell count did not reliably differentiate the etiology in each particular case, although the mean values of the various groups differed significantly. Even cytological investigation was negative in 6 out of 29 malignant ascites. Neither were the immunomodulatory substances such as neopterin, beta 2-microglobulin and interleukin-2 receptors suitable for differentiation. In patients with carcinoma of the prostate the values of prostate-specific antigen were significantly increased in ascites. The best separation between benign hepatic or cardiac ascites and malignant ascites was provided by ferritin (sensitivity 97%, specificity 100%). The values in benign hepatic or cardiac ascites were lower than 150 ng/ml and those in malignant ascites higher than 170 ng/ml.
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PMID:[Tumor markers and immunomodulator substances in ascites--their value as screening and diagnosis parameters]. 247 98

The diagnostic value of ferritin measurements has been evaluated in 59 patients with pleural effusions (PE). The Mean(+/- standard error [SE]) PE-ferritin level was 1913 +/- 720 ng/ml in 10 patients with nonmalignant nontuberculous (nonTB) exudates (Group I), 594 +/- 110 ng/ml in 14 patients with TB effusions (Group II), 1286 +/- 194 ng/ml in 28 patients with malignant exudates (Group III), and 280 +/- 60 ng/ml in 7 patients with transudates (Group IV). Significant difference was found between Group II and Group III (p less than 0.05). The mean (+/- SE) ratio of PE/serum (PE/S) ferritin in Groups I, II, III, and IV was 3.5 +/- 1.1, 10.5 +/- 5.1, 4.9 +/- 1.0, and 2.0 +/- 0.7, respectively, and it showed no significant difference among Groups I, II, and III. There were good correlations between PE-ferritin and PE-LDH or S-ferritin, but no correlation between PE-ferritin and PE-protein. PE-ferritin revealed a considerable overlap among the exudative groups, and was of no value in the differentiation between malignant and nonmalignant (Group I + II) exudates. In the discrimination between exudates and transudates, the diagnostic accuracy (86%) of PE-ferritin was inferior to those (all 98%) of PE-protein, PE-LDH, PE/S protein ratio, and PE/S LDH ratio. Using PE-ferritin greater than or equal to 500 ng/ml in distinguishing malignant exudates from TB effusions, the sensitivity was 79%, specificity 57% and accuracy 71%.(ABSTRACT TRUNCATED AT 250 WORDS)
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PMID:Diagnostic value of ferritin measurements in patients with pleural effusions. 262 13

The author found marked differences in isoferritin patterns between the ferritins of hepatocytes and Kupffer cells in normal adult rats of the Wistar strain. This fact was considered to be a phenomenon of the heterogeneities recognized widely between these two cells from the embryological, morphological and physiological viewpoint. Accordingly, the iron metabolism of hepatocytes and Kupffer cells was studied separately in cells obtained from the livers of rats which had received iron dextran previously. Especially, the concentrations of iron and ferritin and isoferritin patterns in these cells were followed by rats given the different amounts of iron (25, 50, 150 and 200 mg given to the rats) 48 hours previously and also in time course experiment (2, 10 and 30 days) by the rats given 100 mg iron. Serum iron concentration and TIBC were increased markedly 48 hours after administrations of more than 100 mg iron. However RBC count, Hb concentration and Ht showed no changes related to iron administration. In the conditions settled by the author, there were no serious increases in the serum enzyme activities of GOT, GPT, LDH and gamma-GTP. Isoferritin patterns obtained from hepatocytes and Kupffer cells maintained the same characteristics except for a slight shift to the alkaline side in each peak with the respective controls in the rats receiving 100 mg iron. In this experiment, ferritin and iron concentrations in hepatocytes and whole liver showed similarly positive increases in a dose dependent manner, while the concentrations of both compounds in Kupffer cells arrived at their maximums with 100 mg iron and were decreased by larger administrations of iron. In the time course experiment, ferritin concentration increased in hepatocytes, Kupffer cells and whole liver, and arrived at the maximum at 2 days in Kupffer cells and at 10 days in the other two specimens. However the iron concentrations reached their maximums at 2 days respectively and returned almost to the control levels afterwards in all specimens. These results indicated the characteristics of iron metabolism in two kinds of cells, and suggested the differences in the structure and the metabolism of their ferritins.
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PMID:[Iron metabolism in the hepatocytes and Kupffer cells of rats receiving large amounts of iron dextran]. 275 89

Blood enzymatic activities in gastric carcinoma depend on the release from carcinomatous tissues, surrounding non-neoplastic tissues, increased permeability and necrosis of carcinomatous tissues. However, those enzymatic activities did not parallel the extent and macroscopic appearance of the tumor. Various enzyme proteins and gastrointestinal hormones concerning gastric carcinoma and intestinal metaplasia including pepsin, LDH, AFP, beta-glucuronidase, rGTP, lysozyme, ferritin, sialic acid, polyamine, CEA, Ca 19-9, collage, gastrin, immunoglobulin are discussed in this paper. The variation of enzymes and proteins occurring in gastric carcinoma and intestinal metaplasia are well documented. Some of them would be a useful indicator of diagnosis and treatment as a tumor marker.
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PMID:[Various enzymatic activities in gastric carcinoma and intestinal metaplasia]. 309 81


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