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Query: UNIPROT:P02794 (ferritin)
 17,525 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Polycations induce loss of fixed anionic sites in the glomerular capillary wall and epithelial changes similar to those reported in proteinuric conditions. To investigate whether such alterations are accompanied by an increase in glomerular permeability, the distribution of anionic ferritin was studied in kidneys perfused with a polycation (protamine sulfate). Cortical biopsies were examined by light and electron microscopy. Glomerular anionic sites were studied by the colloidal iron reaction. In kidneys perfused with protamine, whether or not pretreated with heparin, there was a marked decrease in glomerular polyanion, a flattening and loss of foot processes, and a significant increase in number of ferritin molecules beyond the inner aspect of the glomerular basement membrane, relative to controls. When protamine-treated kidneys were reperfused with heparin, there was restoration of glomerular polyanion, nearly complete reversion of epithelial changes, formation of protamine-heparin complexes in the capillary wall, and a ferritin distribution comparable to that of controls. These results provide additional evidence evidence of the restrictive role of the glomerular polyanion with respect to the filtration of anionic proteins.
Lab Invest 1978 Dec
PMID:Glomerular permeability: transfer of native ferritin in glomeruli with decreased anionic sites. 73 59

The chorionic villi of placentas, 10 to 40 weeks of gestation, were examined for A and B blood group antigens with an immunoferritin technique. No specific ferritin attachment was shown on the plasma membrane of the villous trophoblasts. Furthermore, after trophoblast cell-surface mucosubstances (perhaps the barrier of the placental antigenicity, according to some authors) were digested with several enzymes, such as neuraminidase, hyaluronidase, chondroitinase ABC, pepsin, trypsin, and pronase, no ferritin tagging was observed on the plasma membrane of the villous trophoblasts. We have concluded that our failure to detect the A and B blood group antigens was not due to the masking of antigens by mucosubstance coating the trophoblasts, but was due to the intrinsic deficit of those antigens in the plasma membrane of the human trophoblasts.
Lab Invest 1976 Dec
PMID:Innumoelectron microscopy of the human chorionic villus in search of blood group A and B antigens. 79 65

A group of 359 healthy children and 49 adults were studied for the purpose of estimating the normal limits for serum iron concentration and transferrin saturation. The 144 children and seven adults who has any other laboratory evidence of iron deficiency (abnormal values of serum ferritin, free erythrocyte protoporphyrin, hemoglobin concentration, or mean corpuscular volume) were excluded. In evaluating the 215 children and 42 adults who met the criteria to be considered normal we found that serum iron concentration and transferrin saturation were significantly lower in children between the ages of 0.5 and 12 years than in adults. We conclude that in children between the ages of 0.5 and 12 years, a transferrin saturation of less than 16% constitutes good evidence of iron deficiency only in conjuction with anemia and low mean corpuscular volume.
J Pediatr 1977 Dec
PMID:Serum iron concentration and transferrin saturation in the diagnosis of iron deficiency in children: normal developmental changes. 92 12

Prevention of iron deficiency in low-birth-weight infants requires iron supplementation before neonatal iron stores are exhausted. In order to accurately determine when this depletion occurs, we measured the hemoglobin, mean corpuscular volume, serum iron/iron-binding capacity, and serum ferritin in 117 low-birth-weight infants (1,000 to 2,000 gm) from 0.5 until 6 months of age. All infants received banked breast milk in the hospital and breast milk or cow milk formula later; those with odd birth dates received 2 mg iron as ferrous sulfate/kg/day starting at 0.5 months; those with even birth dates received no additional iron unless they developed anemia. The results indicate that low-birth-weight infants who receive no supplemental iron may develop iron deficiency by three months of age and that a dose of iron of 2 mg/kg/day started at two weeks of age prevents iron deficiency without providing excess.
J Pediatr 1977 Dec
PMID:At what age does iron supplementation become necessary in low-birth-weight infants? 92 14

Iron deficiency is a frequent complication in chronically hemodialyzed patients because of the significant blood losses associated with this technique. Quantitating iron stores (by marrow examination or serum iron and total iron-binding capacity) on a repetitive basis had been difficult or unreliable, often resulting in failure to recognize iron deficiency superimposed on the existing anemia of chronic renal failure, or overtreating, which can lead to iron excess. Use of the serum ferritin allows easier quantitation of iron stores and, when measured serially in dialysis patients, can predict the emergence of iron deficiency. There was no correlation between serum ferritin levels and serum iron, total iron-binding capacity, or percent transferrin saturation. Iron absorption studies show that food iron absorption is physiologic, increasing when the serum ferritin is below 30 ng/ml, decreasing when more than 300 ng/ml. Treatment of iron deficiency with oral iron compounds increases serum ferritin levels and usually can maintain iron balance.
Ann Intern Med 1977 Dec
PMID:Iron balance in hemodialysis patients. 93 Dec 7

The investigation of chelating agents with potential therapeutic value in patients with transfusional iron overload has been facilitated by the use of Chang cell cultures. These cells have been incubated with [59Fe]transferrin for 22 hr, following which most of the intracellular radioiron is found in the cytosol, distributed between a ferritin and a nonferritin form. Iron release from the cells depends on transferrin saturation in the medium, but when transferrin is 100% saturated, which normally does not allow iron release, desferrioxamine, 2,3-dihydroxybenzoic acid, rhodotorulic acid, cholythydroxamic acid, and tropolone all promote the mobilization of ferritin iron and its release from cells. They are effective to an approximately equal degree. The incubation of [59Fe]transferrin with tropolone in vitro at a molar ratio of 1:500 results in the transfer of most of the labeled iron to the chelator, reflecting the exceptionally high binding constant of this compound. How far these phenomena relate to therapeutic potentially remains to be seen.
Blood 1976 Dec
PMID:The effect of chelating agents on iron mobilization in Chang cell cultures. 100 84

The carbohydrate rich filamentous coat investing the mature Schistosoma manosini cercaria affects important physiological and antigenic properties of the larval body surface. The origin of the filamentous coat and intrinsic topochemical properties of ccrcariae were investigated by fine structural and cytochemical examination of intrasporocyst larvae of various developmental stages. Staining results achieved with concanavalin A-peroxidase, bismuth subnitrate, silver protein, cationic colloidal iron, and polycationic ferritin indicate the presence of both neutral and acidic glycans at the external surface of the trilaminar tegumental plasmalemma, the latter saccharide moieties conferring upon this surface a superficial electronegative charge. The filamentous coat, apparent only on relatively well-developed larvae, is rich in neutral glycans, but fails to stain with cationic cytochemical reagents. Appearance of the surface coat occurs coincident with the differentiation of tegumentary cytons, the elaboration of carbohydrate-containing vesicles by Golgi complexes within these cell bodies, and the translocation of vesicles from sites of formation to the tegumental syncytium. It is likely that those saccharides, glycoproteins, and/or glycolipids present within the neutral filamentous coat, and those which constitute the acidic layer immediately superticial to the larval body surface, are intrinsic molecular constituents of the cercarial tegumental plasmalemma. Both the neutral filamentous coat and subjacent acidic layer may be regarded as distinct functional elements of the larval body surface glycocalyx. The molecular architecture of this membrane complex apparently reflects the specializations necessary for survival in fresh water followed by rapid adaptation to the serum environment of the mammalian host.
J Parasitol 1976 Dec
PMID:Schistosoma mansoni: topochemical features of intrasporocyst cercariae. 100 81

The effect of long-term dietary cadmium treatment upon the distribution of the metals copper, iron and zinc has been compared in various organs of male and female rats. The renal accumulation of cadmium was similar in both sexes without a plateau being reached. In contrast, the hepatic accumulation of cadmium was higher in the female than in the male rat and a plateau was observed after 30-35 weeks of dietary cadmium treatment. Most of the cadmium which accumulated in these organs was recovered in the metallothionein fraction andthe concentration of hepatic cadmiumthionein in the female rat was correspondingly higher than in the male rat. Accumulation of cadmium was associated with an increased zinc concentration in the liver and an increased copper concentration in the kidney; these increases were correlated with increases in liver and kidney metallothioneins induced by cadmium. Uptake of cadmium into organs other than liver and kidney occurred to a small extent but was not associated with changes in the concentration of copper and zinc. Cadmium also accumulated in the intestinal mucosa where it could be recovered in a fraction corresponding to metallothionien. A loss of iron from the liver and kidney was also observed following dietary cadmium treatment and involved mainly a loss of iron from ferritin.
Chem Biol Interact 1976 Dec
PMID:Influence of dietary cadmium on the distribution of the essential metals copper, zinc and iron in tissues of the rat. 100 32

The distribution of anionic binding sites has been investigated in the isolated Golgi complex using cationic ferritin. The greatest density of anionic sites occurs on the tubular network and small vesicles, and this binding is accompanied by increased levels of galactosyltransferase activity. The density of anionic sites on the cisternae is less than on the tubules and shows anisotropic distribution, with higher density on the convex surface and lower density on the concave surface. The distribution of anionic sites may reflect the functional activity of the Golgi complex and possibly the interaction or cohesion between cisternae in this organelle.
J Cell Biol 1976 Dec
PMID:The distribution of anionic sites on the surface of the Golgi complex. 103 90

Zonaless rabbit ova, exposed to Concanavalin A or Wheat Germ Agglutinin, then to uterine capacitated sperm produce pronuclear, 2 and 4 stage embryos that are indistinguishable from controls. Absence of cortical granules indicates that the ova were fertilized and not merely activated. Survival of lectin-bearing receptors during the period necessary for fertilization was evaluated in ova marked with ferritin-conjugated lectin.
J Exp Zool 1976 Dec
PMID:Electron microscope assessment of fertilization of rabbit ova treated with concanavalin A and wheat germ agglutinin. 103 48


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