Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:P02794 (ferritin)
 17,525 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Metabolic balance for lead and cadmium were carried out in 23 healthy elderly people aged 69.7 to 85.5 yr while living in their own homes and eating self-selected diets. Mean intakes of lead and cadmium were 54.6 and 8.6 micrograms/day, with mean retentions of -8.7 and -1.7 micrograms/day, respectively. Daily dietary lead correlated (p less than 0.05) with the intake of energy, nitrogen, calcium, iron, and zinc but not with manganese or copper. Dietary intake of cadmium correlated (p less than 0.05) only with that of zinc and manganese. There was a highly significant (p less than 0.001) inverse correlation between the percentage cadmium absorbed and body iron stores measured as serum iron, percentage iron saturation, and ferritin. Mean whole blood concentrations were 138 micrograms/l for lead and 0.79 microgram/l for cadmium. The negative balances observed in these elderly people were very different from the positive balances found in a previous similar study in children.
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PMID:The intake and excretion of lead and cadmium by the elderly. 671 83

Fortification of dairy products with trace metals requires use of assimilable compounds that do not catalyze off-flavors due to lipid peroxidation but show good biological availability. The Fe(III) and Cu(II) chelates of the promising chelator, lactobionic acid, have been compared to Fe(II) and Cu(II) salts for their ability to improve hematological status in a mildly anemic population. Fe- and Cu-fortified cow milk was administered to children (aged 6 to 15) in the Durango, Mexico, "school lunch" program. Children drank milk providing 20 mg Fe and 3 mg Cu as ferric/cupric lactobionate ("chelate") or ferrous/cupric chloride ("salt") for 5 of 7 days/wk for 3 months. Supplementation with "salt" and "chelate" raised Hb significantly by 1 and 0.3 g/dl, respectively, above the control (unsupplemented) group. No significant change was observed in incremental serum ferritin, serum Fe, or transferrin saturation, or in final serum Cu. Ferric lactobionate shows poorer bioavailability than ferrous ion in the presence of Cu, but milk can be an excellent vehicle for Fe or Cu supplementation.
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PMID:Bioavailability of iron- and copper-supplemented milk for Mexican school children. 689 32

Iron, copper, and zinc utilization were examined in nine adult males fed a moderate calcium-moderate phosphorus diet (MCaMP), a moderate calcium-high phosphorus diet (MCaHP), and a high calcium-high phosphorus diet (HCaHP) during a 39-day balance study. The moderate and high calcium diets contained 780 mg and 2382 mg calcium daily, respectively. The moderate and high phosphorus diets contained 843 and 2442 mg phosphorus daily, respectively. The calcium supplements were fed as calcium gluconate, while the phosphorus supplements were fed as glycerol phosphate. Subjects lost more iron and copper in their feces and apparently retained less iron and copper when fed the HCaHP diet than when fed the other two diets, but these effects were not statistically significant. Urinary iron and copper excretion were significantly affected by the dietary treatments. Dietary treatments had no effect on subjects' fecal and urinary losses of zinc nor on their apparent retention of zinc. Plasma iron, zinc, copper, and transferrin levels and serum ferritin levels were not affected by the dietary treatments.
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PMID:Effect of dietary calcium and phosphorus levels on the utilization of iron, copper, and zinc by adult males. 705 62

A study population consisting of 66 mentally retarded individuals, 60 with and six without pica, was evaluated for iron status, and for plasma and hair zinc, copper, and magnesium levels within a month of known dietary intake. The parameters were all within the normal range for individuals without pica. In contrast, subjects practicing pica had low plasma zinc and elevated plasma copper values as compared to those without pica. Plasma magnesium was in the low normal range for all individuals in the study population. Among the indicators of iron status measured, Hb, hematocrit, plasma iron, total iron-binding capacity, iron saturation, and plasma ferritin, several values were low (p less than 0.001). Depression in plasma zinc level was related to the type and severity of the pica. In plasma, zinc was positively correlated with iron and negatively correlated with copper. No relationships were found between dietary intakes and plasma levels of these minerals. The data suggest that malabsorption of zinc and iron were associated with some types of pica although the individuals received adequate dietary intake of minerals. Zinc, copper, and magnesium concentrations in hair were within normal ranges. Hair was a less sensitive indicator than plasma of trace element status.
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PMID:Pica and mineral status in the mentally retarded. 708 Oct 93

Nutritional parameters of 87 Navajo women were assessed at term and in 23 of these women after 1 month of lactation. Serum levels of zinc, retinol-binding protein, folacin, protein, Hb, and ferritin and hair zinc content were determined. Twenty-four-hour dietary recalls were recorded for the subsample of 23 women. Median nutrient intakes were less than 60% of the Recommended Dietary Allowance of calcium, magnesium, zinc, copper, vitamins A (lactation only), D, E, and B6, biotin, and folacin. Serum zinc fell below 50 microgram/dl in 68% of the subsample at term and remained below 65 microgram/dl 43% during lactation. Serum retinol was below normal ( less than 33 microgram/dl) in 24% of these women at term and 23% at 1 month. Low serum folacin (less than 6 ng/ml) was detected in 9% at term and 24% at 1 month. Anemia was present in 15 to 20% of the women. Serum protein, retinol-binding protein, ferritin, and hair zinc were essentially normal. Biochemical findings confirmed dietary inadequacies among Navajo women and indicate needed nutritional improvement.
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PMID:Nutritional assessment of pregnant and lactating Navajo women. 729 50

Earlier investigators observed that addition of large amounts of zinc to the diet or rats can retard growth, lower their hemoglobin levels and reduce storage of iron. In the present studies, addition of 0.75% zinc to a synthetic diet confirmed the reduced storage of iron in the livers and spleens of growing rats, but failed to show an effect on growth rate or hemoglobin levels. The adverse effects of zinc excess on growth and hemoglobin level could, however be reproduced by replacing the Rogers-Harper salt mixture used in the present studies with the Wesson salt mixture use in the earlier studies. Rats fed excess zinc along with the Wesson salt mixture grew less well, had anemia and also had low level in copper in their livers. It is suggested that addition of zinc to the low copper Wesson salt mixture reduced copper absorption sufficiently it deplete liver copper to a level at which mobilization of liver iron stores by a copper-dependent mechanism became impaired, thus depriving red cell production and tissue enzymes of stored iron. The mechanism by which iron stores are depleted by addition of zinc to the better balanced Rogers-Harper salt mixture remains unexplained It is not due to interference by zinc with iron adsorption from the diet nor with cellular uptake of iron from circulating transferrin, and the capacity of tissues to store iron as ferritin is not impaired.
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PMID:Effect of excess dietary zinc on tissue storage of iron in rats. 729 94

Female guinea pigs were fed diets varied in ascorbic acid and iron concentration for 21 days. Tissue concentrations of ascorbic acid, iron (total, ferritin and hemosiderin) and copper were determined in blood, liver and spleen. High dietary ascorbic acid (10 times control) increased tissue ascorbic acid levels and produced a decrease in liver ferritin and hemosiderin, without altering liver or plasma total iron. Conversely, splenic total iron increased with no changes in ferritin and hemosiderin iron. The increased ascorbic acid did lower copper levels in blood and liver, 39% and 52%, respectively. In guinea pigs maintained on an ascorbic acid-free diet for 21 days, a decrease in hepatic ferritin and total iron was observed, as well as an increase in splenic hemosiderin and total iron. No change in plasma iron was observed nor were any of the copper pools altered. Intake of high dietary iron (10 times control) increased hepatic iron stores and produced a reciprocal decrease in hepatic copper. Even though splenic iron increased, no significant change in copper resulted. The significance of these nutrient interactions is discussed.
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PMID:Interrelationship of dietary ascorbic acid and iron on the tissue distribution of ascorbic acid, iron and copper in female guinea pigs. 738 3

L-(-)-ascorbate mobilizes iron from horse-spleen ferritin in the presence of oxygen at pH 8.0. The reaction is strongly stimulated by Cu2+. Dehydroascorbate and other stable oxidation products of ascorbate are ineffective. We present evidence that monodehydroascorbate mobilizes ferritin iron by reduction.
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PMID:Rapid mobilization of ferritin iron by ascorbate in the presence of oxygen. 740 58

Serum micronutrient levels and their relationship to precancerous gastric lesions were studied in 600 subjects aged 35-64 years living in high-risk area of gastric cancer in Linqu County, Shandong Province. Serum micronutrient levels in local residents were 0.54 micrograms/ml, 0.29 micrograms/ml, 3.14 micrograms/ml, 9.62 micrograms/ml, 30.2 micrograms/L, 924 micrograms/L, 1 016 micrograms/L, and 42.0 micrograms/L for vitamin A, beta-carotene, vitamin C, vitamin E, selenium, zinc, copper and ferritin, respectively. Serum levels of beta-carotene, vitamin C and ferritin, and ratio of serum levels of zinc and copper correlated inversely to severity of pathological changes in gastric mucous membrane. With increase of serum level of beta-carotene or vitamin C, odds ratios (OR) of intestinal dysplasia and metaplasia lowered to 0.8, 0.6 and 0.9, 0.5, respectively, and with increase of those of both beta-carotene and vitamin C, their OR lowered further to 0.16, with patients of chronically atrophic gastritis as controls. It indicated maybe beta-carotene and vitamin C played a strong contributing role in protecting from development of precancerous gastric lesions.
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PMID:[Relationship between serum micronutrients and precancerous gastric lesions]. 758 56

Cystic fibrosis patients are at risk for nutrient deficiencies from malabsorption related to exocrine pancreatic insufficiency. This research examined the copper homeostasis of children with cystic fibrosis. Our objective was to measure cytochrome oxidase and copper-zinc superoxide dismutase activities in mononuclear cells, neutrophils, and erythrocytes of adolescents with cystic fibrosis, as well as plasma copper and ceruloplasmin. Thirteen adolescents with pancreatic insufficiency caused by cystic fibrosis were compared with 10 age- and sex-matched control subjects. Serum copper concentrations and ceruloplasmin measurements were not significantly different between the two groups. Cytochrome oxidase activity was significantly lower in the mononuclear cells and copper-zinc superoxide dismutase activity was significantly lower in the neutrophils and erythrocytes of the cystic fibrosis group. Other measures of trace element status such as hemoglobin concentration, serum ferritin, serum zinc, glutathione peroxidase activity, and manganese superoxide dismutase activity were not different between the two groups. Reductions in the activity of two copper-dependent enzymes suggest abnormal copper homeostasis in this population.
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PMID:Reduced copper enzyme activities in blood cells of children with cystic fibrosis. 766 Nov 26


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