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Query: UNIPROT:P02794 (ferritin)
 17,525 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

In order to follow the dynamics in the reaction of iron kinetic variables to acute infection, 8 renal transplantation patients were followed with test samples every second or third day for about two months. It was found that they just as previously shown in otherwise healthy subjects, responded to acute infection with a rise in serum ferritin levels, sometimes to very high values. In most cases the ferritin elevation started within two days after the onset of fever. The peak was reached within a week, except when very high values were obtained. The fall in serum ferritin after recovery from infection was much faster than in previously investigated groups of patients: the plasma half disappearance time for ferritin in one case was but 1.5 days. Transferrin did not change in response to infection. The expected fall in serum iron during infection was often absent and sometimes obscured by unexpected, sharp peaks in serum iron, which bore a temporal relationship to episodes of transplant rejection in 7 of 12 cases.
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PMID:Serum ferritin during infection. A longitudinal study in renal transplant patients. 38 53

Ferritin is an iron storage protein of high-molecular weight which is primarily present in the liver, spleen, and bone marrow. A very sensitive immunoradiometric assay has been developed which permits determination of serum concentrations in normal persons and in patients with a variety of different disorders. In normal subjects, the serum ferritin concentration correlates very well with total body iron stores as measured by phlebotomy. The serum ferritin concentration is reduced in patients with iron-deficient anemia and is significantly higher in patients who are anemic for other reasons. Subject areas discussed in this review include the details of the immunoradiometric procedure, the sensitivity and accuracy of the assay, factors influencing the assay, values characteristic of a variety of clinical disorders, and the utility of the assay in clinical medicine and public health.
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PMID:Serum ferritin assay. 40 69

The subcellular localization of intraduodenally administered 59Fe has been studied in control, pregnant, and nonpregnant rats absorbing iron at different rates. Binding of iron to the particulate fractions of mucosal homogenates produced by centrifugation at 500, 10,000, and 100,000 X g did not vary among groups despite significant alterations in iron transport rates. Study of the 10,000 X g supernatant fluid showed that increased iron transport in iron-deficient and day 20- to 21-pregnant rats was associated with an increase in 59Fe binding to a particulate fraction of the mucosal homogenate. Although only 10 to 15% of the total mucosal 59Fe was present in the 100,000 X g supernatant in all groups, significant differences were demonstrated, among groups in the binding of iron to the three proteins present in this supernatant fraction. The proteins have been identified as ferritin, transferrin, and a protein of lower molecular weight than transferrin. Increased iron absorption was associated with a reduction in ferritin 59Fe binding and an increase in 59Fe bound to protein 3. Conversely, reduced iron absorption, was associated with increased ferritin 59Fe content and decreased protein 3 59Fe content. By studying day-21 pregnant rats 5 and 18 hr posthysterectomy it was possible to demonstrate a 12- to 18-hr delay in the intestinal mucosal protein response to alterations in the stimulus to iron absorption.
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PMID:Study of the subcellular localization of 59Fe and iron-binding proteins in the duodenal mucosa of pregnant and nonpregnant rats. 40 60

Tubular uptake of ferritin given intravenously was studied in the right and left kidneys of 74 Goldblatt-hypertensive rats. Previous observations pointed out the pathologically enhanced permeability of glomerular barrier as the cause of the phenomenon. It was assumed, that the extent of tubular areas taking up ferritin, refers to the number of damaged glomeruli. The process was characterized semiquantitatively by planimetric measurements and determination of the non-hemin iron concentration in the renal cortical tissue. A more frequent and extensive tubular ferritin-uptake (and glomerular damage) was bilaterally recorded in the kidneys of malignant hypertensive rats in comparison to the benign ones. The development of the phenomenon in the clamped kidneys, being defended from high blood pressure, suggests a humoral factor behind the enhanced glomerular permeability. Saline intake has a beneficial effect on the glomerular damage similar to the hypertensive angiopathy.
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PMID:Renal tubular ferritin-uptake, a consequence of the increased glomerular permeability, during the benign and malignant course of renal hypertension in rats. 42 54

In the proximal tubular cells of rats or mice given a single, parenteral dose of lead, clusters of ferritin are frequently associated with characteristic cytoplasmic fibrillar bodies. To learn more about this relationship, we have investigated content and synthesis of ferritin protein and incorporation of iron into ferritin in rat kidneys 48 hours after a single parenteral dose of lead (10 microgram/g). By immunoradiometric assays, we found that the kidneys of female rats, whether treated with lead or not, contained significantly more ferritin protein than did kidneys of males of the same age and provenance. Administration of lead diminished (or did not significantly alter) the incorporation of 14C-amino acids into newly synthesized ferritin protein. Contrary to expectation, administration of lead tended to depress incorporation of 59Fe into kidney ferritin in rats maintained on standard rations and distilled water. Electron microscopy confirmed the presence of clusters of ferritin in close association with dense fibrillar bodies in the cytoplasm of proximal tubular cells of rats given lead. Considered together, the findings indicate that clustering of ferritin next to the dense fibrillar cytoplasmic lesions is a selective effect of lead that requires neither augmented synthesis of ferritin protein nor increased incorporation of iron into preexisting ferritin.
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PMID:Ferritin in rat kidneys with specific lesions due to a single dose of lead. 42 36

1. An epidemiological study of iron status in general practice has been undertaken. An age-sex register was established and a 10% stratified random sample (194 males and 220 females) of the patients above the age of 15 years was studied. A full blood count, serum Fe concentration, transferrin saturation and serum ferritin concentration were measured and correlated with clinical features associated with Fe deficiency. 2. The geometric mean for serum ferritin for males was 77 micrograms/l (20-196 micrograms/l) and for females 37 micrograms/l (8--177 micrograms/l). A low serum ferritin (male less than 30 micrograms/l, female less than 20 micrograms/l) in the absence of anaemia was found in fifteen males and thirty-five females. In this group forty patients had clinical features which are aetiologically associated with Fe deficiency. The incidence of similar features in a control group of thirty-three patients was seven. 3. It is suggested that this is indirect evidence that serum ferritin concentration is the most sensitive monitor of Fe status enabling the detection of pre-anaemic Fe deficiency.
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PMID:Iron status in a general practice and its relationship to morbidity. 42 82

The serum ferritin concentration was measured in 1417 Indians and 310 Inuit aged 1 to 89 years. The subjects were initially selected to produce a representative sample of the entire native population, but the rate of nonresponse was high, and the results reported in this paper are representative only of the people studied.In males the median serum ferritin values increased during early life and tended to plateau after the age of 30 years. In females the median values rose during childhood, tended to plateau during adolescence, increased slightly during the reproductive period, then gradually rose thereafter. Ranges of values were wide in all age groups, reflecting the variations in body iron stores. When compared with the Inuit, the Indians had a significantly higher prevalence of abnormal serum ferritin values.From an analysis of the serum ferritin values in Indians it is probable that iron stores were reduced in approximately 30% of children, 40% of adolescents, 34% of nonpregnant women of reproductive age, 11% of older women and 5% of adult males. The corresponding figures for the Inuit were 15%, 23%, 22%, 6% and 1%. In contrast, iron deficiency anemia was found in only 3% to 4% of native peoples. If "normality" requires more than small amounts of iron stores to meet physiologic needs, the results suggest a high probability of iron deficiency in 20% to 40% of native children, adolescents and nonpregnant women of reproductive age, and in 0% to 10% of other subjects; but if "normality" is defined as adequate iron stores for erythropoiesis the prevalence of iron deficiency was approximately 1% to 2% in children and adolescents, 3% to 5% in women and less than 1% in adult males.
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PMID:Evaluation of the body iron status of native Canadians. 42 65

Eleven patients with porphyria cutanea tarda were studied. Biochemical confirmation of the clinical diagnosis required only determination of the total urine porphyrin concentration in a sample of urine voided on rising in the morning. The patients were divided for convenience of discussion into four groups differing in age, sex and etiologic factors. Of the six patients in whom a liver biopsy was done one was shown to have micronodular cirrhosis. Except for a modest elevation in the serum glutamic oxaloacetic transaminase values when the patients were first seen, no evidence was found for liver disease apart from the presence of porphyria cutanea tarda. One patient recovered solely by abstaining from alcohol consumption. Five patients underwent phlebotomy; their iron stores had been found to be between 2 and 3 g. Decreasing urine porphyrin values correlated well with decreasing serum ferritin values during the course of phlebotomy. Porphyria cutanea tarda, which is due to a deficiency of uroporphyrinogen decarboxylase, is manifested in association with alcohol abuse, estrogen therapy, exposure to chlorinated hydrocarbons or increased tissue iron stores, or a combination of these factors. Although relatively uncommon, this condition raises important and unresolved issues regarding the hepatotoxicity of alcohol, estrogens, chlorinated hydrocarbons and iron.
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PMID:Porphyria cutanea tarda: clinical and laboratory features. 42 87

Spontaneously breathing mice were exposed to an aerosol of iron oxide for 3 hours. Participation of the tracheal and bronchial epithelium in the uptake of iron oxide was noted immediately following the exposure and at 1 day, 4 days, and 7 days postexposure. Observations with the electron microscope revealed that iron oxide was pinocytosed and converted to ferritin and hemosiderin in all epithelial cell types except mucous cells. Iron content increased over time and approximately 50% of the nonmucous cells contained hemosiderin by 4 days postexposure. Ferritin and hemosiderin, but not iron oxide, were noted in connective tissue cells in the submucosa beneath the airway epithelium. Soluble iron and/or ferritin produced in the airway epithelial layer was transported to the submucosa, but normal epithelium prevented the penetration of deposited iron oxide particles to the connective tissue compartment.
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PMID:Uptake of iron aerosols by mouse airway epithelium. 43 Oct 45

The percentage absorption from a 3 mg dose of ferrous iron was measured in 50 subjects with iron stores that varied over a wide range. Iron status was assessed by a number of measurements, including the haemoglobin concentration, the plasma iron concentration, the total iron-binding capacity, the plasma ferritin concentration and the concentration of non-haem iron in the bone marrow. There were good inverse correlations between the log percentage iron absorption and both the log marrow non-haem iron concentration (r -0.94; P less than 0.001) and the log plasma ferritin concentration (r -0.78; P less than 0.001). In addition, there was a positive ferritin concentration (r +0.84; P less than 0.001). These results suggest that reticuloendothelial iron stores represent an important determinant of iron absorption and that their size can be guaged from the plasma ferritin concentration.
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PMID:The relationship between marrow iron stores, plasma ferritin concentrations and iron absorption. 43 49


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