Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UNIPROT:P02794 (ferritin)
 17,525 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Magnetic particle mediated transport in combination with nanomaterial based drug carrier has a great potential for targeted cancer therapy. In this study, doxorubicin encapsulation into the apoferritin and its conjugation with magnetic particles was investigated by capillary electrophoresis with laser-induced fluorescence detection (CE-LIF). The quantification of encapsulated doxorubicin was performed by fluorescence spectroscopy and compared to CE-LIF. Moreover, the significant enhancement of the doxorubicin signal was observed by addition of methanol into the sample solution.
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PMID:Apoferritin modified magnetic particles as doxorubicin carriers for anticancer drug delivery. 2380 1

Laser-induced fluorescence imaging of aluminum atoms (Al-PLIF) is used to analyze the spatio-temporal behavior of aluminized solid propellant combustion. Using alternating LIF and chemiluminescence emission images of the particles in the gaseous and liquid phase evolving close to and far above the dynamically varying propellant surface, sequences of images were recorded and analyzed. The good sensitivity achieved enabled us to track the dynamics of the flame in the vicinity of particles detected all along the flame extension and up to 1.5 MPa. Analysis of wide-field images enabled droplet velocity measurements due to the high LIF sampling rate (5 kHz). The observed typical plume structures were in good agreement with alumina-formation prediction and previous shadowgraphy visualization. High-resolution sequences of images showed gaseous distribution behavior around the molten particles. The Al vapor phase was thus found to extend between 3 and 6.5 radii around the particles. Particle detachment dynamics were captured just above the propellant surface.
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PMID:Imaging Aluminum Particles in Solid-Propellant Flames Using 5 kHz LIF of Al Atoms. 3136 63

Participation in a long-distance run, e.g., marathon or ultramarathon, continues to increase. One side effect of long-distance running is excessive inflammation manifested by the rise in inflammatory cytokine levels. We here aimed to elucidate the effects of 10-day ischemic preconditioning (IPC) training on marathon-induced inflammation and to evaluate the role of serum-stored iron in this process. The study involved 19 recreational runners taking part in a marathon. IPC training was performed in the course of four cycles, by inflating and deflating a blood pressure cuff at 5-min intervals (IPC group, n = 10); the control group underwent sham training (n = 9). The levels of inflammatory and others markers (FSTL-1, IL-6, IL-15, leptin, resistin, TIMP-1, OSM, and LIF) were measured before and 24 h after training; and before, immediately after, and 24 h and 7 day after the marathon. The 10-day IPC training increased serum leptin levels. IL-6, IL-10, FLST-1, and resistin levels were increased, while TIMP-1 levels were decreased in all runners after the marathon. The changes were significantly blunted in runners from the IPC group compared with the control group. Baseline serum iron levels correlated with IL-6 and FSTL-1 levels; serum ferritin correlated with IL-6, FSTL-1, and resistin levels after the marathon. Conversely, serum TIMP-1 levels inversely correlated with serum iron levels. Although not evident at baseline, IPC training significantly reduced marathon-induced inflammation. In addition, the reduced responsiveness and attenuation of running-induced inflammation were inversely related to baseline serum iron and ferritin levels.
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PMID:Effect of Ischemic Preconditioning on Marathon-Induced Changes in Serum Exerkine Levels and Inflammation. 3319 67