Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UNIPROT:P02794 (
ferritin
)
17,525
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Plant
ferritin
represents a novel class of iron supplement, which widely co-exists with phenolic acids in a plant diet. However, there are few reports on the effect of these phenolic acids on function of
ferritin
. In this study, we demonstrated that cinnamic acid derivatives, as widely occurring phenolic acids, can induce iron release from holo soybean seed
ferritin
(SSF) in a structure-dependent manner. The ability of the iron release from SSF by five cinnamic acids follows the sequence of
Cinnamic acid
> Chlorogenic acid > Ferulic acid >
p
-Coumaric acid >
Trans
-
Cinnamic acid
. Fluorescence titration in conjunction with dialysis results showed that all of these five compounds have a similar, weak ability to bind with protein, suggesting that their protein-binding ability is not related to their iron release activity. In contrast, both Fe
2+
-chelating activity and reducibility of these cinnamic acid derivatives are in good agreement with their ability to induce iron release from
ferritin
. These studies indicate that cinnamic acid and its derivatives could have a negative effect on iron stability of holo soybean seed
ferritin
in diet, and the Fe
2+
-chelating activity and reducibility of cinnamic acid and its derivatives have strong relations to the iron release of soybean seed
ferritin
.
...
PMID:Iron Release from Soybean Seed Ferritin Induced by Cinnamic Acid Derivatives. 2973 93
