Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UNIPROT:P02794 (
ferritin
)
17,525
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The nucleus (but not the kinetoplast) of Trypanosoma rhodesiense is the principal target for trypanocidal attack by
Daunomycin
in vitro and
Daunomycin
-protein conjugates in vivo; free
Daunomycin
is inactive in vivo. Nucleolar segregation and abnormal distribution of heterochromatin occur after drug treatment as in tumour cells. Other abnormal changes include formation of cytoplasmic clefts and autophagic vacuoles, increased prominence of the tubular collection system, and exocytotic vesicle production. Large masses of
ferritin
accumulate in white cells after treatment with the drug-
ferritin
conjugate but no
ferritin
was detectable in trypanosomes.
...
PMID:Effects of Daunomycin and Daunomycin-protein conjugates on the ultrastructure of Trypanosoma rhodesiense. 666 10
