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Query: UNIPROT:P02794 (ferritin)
 17,525 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The purpose of this study is to find the relationship between the serum iron level and defensive function by observing the iron metabolic change following surgical operation, including serum iron, serum ferritin, and urinary iron excretion of TPN patients, and by measuring the NBT test of neutrophilic leukocyte and the level of serum immunoglobulins simultaneously. Thirty surgical patients were studied (10 cholecystectomies, 10 modified radical mastectomies, and 10 subtotal gastrectomies). Following surgical operation, the serum iron level dropped significantly as the result of the stress of operation rather than blood dilatation or urine iron excretion. Both serum ferritin level and the NBT test of neutrophils increased significantly. These results showed that the serum iron may be related to the phagocytic function of neutrophils. Hypoferremia following surgical operation may be a defensive mechanism to prevent postoperative infection.
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PMID:[Hypoferremia following surgery: a defense mechanism after operative trauma]. 236 24

Serum ferritin levels are often elevated in patients with certain cancers and these elevations are, in part, derived from the tumors. In such patients, the increased levels of serum ferritin are associated with a poor prognosis. This association may be explained in part by biological effects of ferritin on lymphocytes: inhibition of E-rosette formation, masking of cell surfaces and suppression of lymphocytes' response to mitogens in vitro. The authors hypothesized that ferritins from tumor tissues also exert adverse effects on human granulocytes that are involved in tumoricidal activity. Three granulocyte functions were tested: nitroblue tetrazolium test, phagocytosis, and production of hydrogen peroxide. The results supported the authors' hypothesis: NBT reduction and phagocytosis are decreased in granulocytes exposed to ferritins, more so with tumor ferritins, than normal ferritin, and H2O2 production is less in granulocytes previously exposed to ferritins from tumor and nontumor tissues than cells not exposed to ferritins. However, the inhibitory effects of ferritins on H2O2 production can be reversed if granulocytes are further stimulated by phorbol myristate acetate (a membrane stimulant). If the elevated serum ferritin in cancer patients impairs granulocyte functions, in vivo, then it may increase the risk of infection, decrease tumoricidal host responses, and, thereby, contribute to the poor prognosis of these individuals.
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PMID:Effects of isoferritins on human granulocytes. 272 May 99

Elementary bodies have been detected in the L-forms of various bacteria, irrespective of their strain, the phase of development and stabilization of their culture. Elementary bodies have been found to have all organoids peculiar to other L-culture cells (the unit membrane, the nucleoid, ribosomes, more seldom mesosome-like structures and the outer membrane of the cell wall), which is indirectly indicative of their possible viability. The cytoplasmic membrane of elementary bodies contains dehydrogenases (detected in the NBT test), has the hydrophobic layer structure typical of bacterial membranes and, judging by the results of the ferritin test, possesses the same antigenic properties as the cytoplasmic membrane of other L-culture cells. Nevertheless, the above-mentioned properties are far from being the attribute of every elementary body, and the completeness of their manifestation is not directly related with the size of elementary bodies.
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PMID:[Structural features of the elementary bodies of bacterial L-forms]. 726 18