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Query: UNIPROT:P02794 (ferritin)
 17,525 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The iron storage macrophage has been isolated from the marrow of Imferon-treated mice and studied in vitro by morphologic, histochemical, and functional tests and isotope labeling techniques. These macrophages on stained preparations are large, many times binucleate cells (up to 150 mu), and show Prussian blue reactivity. In Epon-embedded, stained thick sections they contain elongated narrow basophilic inclusions. These macrophages are actively phagocytic and pinocytic; histochemical studies show that these cells are rich in acid phosphatase, nonspecific esterase, and PAS diastase-resistant activity. Iron storage macrophages do not incorporate the 3H-thymidine. The electron microscopic appearance of this macrophage shows that the cell has ferritin free in the cytoplasm and several types of cytoplasmic granules: those with large quantities of electron-dense ferritin and/or hemosiderin (type A), elongated granules (type B) with moderately electron dense homogeneous matrix and some ferritin at the periphery, and granules with heterogeneous content (type C). The above findings demonstrate that the iron storage cell is a mature macrophage which contains hydrolases, ferritin, and a unique population of cytoplasmic granules which are lysosomal in nature. There is some evidence to suggest that the unusual lysosome (type B granule) occurs after macrophages have ingested erythrocytes.
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PMID:Morphologic and functional characteristics of bone marrow macrophages from imferon-treated mice. 4 60

Porphyria cutanea tarda (PCT) and experimental porphyria are characterized by a decreased activity of the enzyme uroporphyrinogen decarboxylase, and accumulation of uroporphyrins and heptacarboxylporphyrins in the liver. Iron (Fe) plays an important role in PCT and experimental porphyria. Biochemically and electron microscopically, we examined the relationship between Fe and porphyrins in liver tissue of C57BL/10 mice made porphyric by administration of iron dextran as Imferon (IMF), and in liver biopsies of patients with symptomatic PCT. Accumulation of uroporphyrins and heptacarboxylporphyrins, and an increased amount of Fe were observed in livers of mice treated with IMF and in liver biopsies of patients with PCT. In mice treated with IMF, the activity of uroporphyrinogen decarboxylase was decreased. Both in livers of mice treated with IMF and in livers of patients with PCT, needle-like structures, representing uroporphyrin crystals, were observed by electron microscopy. Uroporphyrin crystals and Fe (as ferritin) were observed in the same hepatocyte. Moreover, there was a striking morphological correlation between uroporphyrin crystals and ferritin-Fe, suggesting a role for (ferritin-)Fe in the pathogenesis of porphyria.
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PMID:The role of iron in experimental porphyria and porphyria cutanea tarda. 138 28

The effect of intravenously infused iron-dextran (Imferon) on the progression of antigen induced monarticular arthritis in rabbits was studied. A rapid deposition of iron and apoferritin in the synovia of arthritis joints occurred after infusion of iron-dextran during either the acute or chronic phases of the disease. This coincided with the appearance of catalytic (bleomycin reactive) iron in the synovial fluid. There was no evidence, however, for an exacerbation of the antigen induced arthritis as a result of the iron-dextran, and synovial and bleomycin reactive iron concentrations decreased with time after administration, indicating a redistribution of the synovial iron load. Thus although intravenously infused iron-dextran appears to 'prime' the rabbit arthritic joint transiently with the potential for iron stimulated oxygen free radical damage, other factors may determine its occurrence.
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PMID:Effect of intravenous iron-dextran (Imferon) infusion on antigen induced monarticular arthritis in rabbits. 146

Sixty pregnant patients with a haemoglobin (Hb) less than 8 g/dl and proven iron-deficiency anaemia were randomly allocated to two treatment groups. Group A received the usual recommended dose of iron dextran (Imferon; Fisons) and group B received two-thirds of the recommended dose. A further 30 patients received oral iron (group C). There was no difference in Hb value between the three groups 4 weeks after treatment or 3 months after delivery. At 6 months after delivery, a higher mean Hb value was found in the patients in group A than those in groups B and C. Significantly higher serum ferritin levels were found in group A and this difference was still present 6 months postnatally. There was no significant difference in the incidence of delayed reactions between the two groups who received iron dextran.
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PMID:Iron dextran in the treatment of iron-deficiency anaemia of pregnancy. Haematological response and incidence of side-effects. 199 36

The haematological response after infusion of total and two-thirds doses of iron dextran (Imferon; Fisons) was studied in 31 pregnant women with iron deficiency in the second and third trimesters. The increase in serum ferritin values was found to be greater with the full dose than with the two-thirds dose. Although haemoglobin values and mean corpuscular volume improved, the response was not statistically significant.
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PMID:[An evaluation of the hematological response to iron dextran by pregnant women with iron deficiency]. 291 79

Assays employing iron-limited solid and liquid, defined and complex media were devised to test the iron requirements of Neisseria meningitidis. A variety of tests yielded no evidence for the secretion of a soluble iron-binding substance (siderophore) by the meningococci. The meningococci were unable to use iron bound to some common hydroxamate- and catechol-type siderophores or even compete with them for iron in the growth medium. A total of 20 strains of meningococci, differing widely in their virulence for mice, were similar in ability to acquire iron from a variety of iron-containing substances; the iron in such compounds as hog gastric mucin, citrate, hemoglobin, and myoglobin was easily acquired, whereas the iron in compounds such as ferrioxamine B, ferrichrome,ferritin, Imferon, cytochrome c, FePO4, and [Fe(OH)3]n was not readily available. No correlation was noted between the ability of particular strains to obtain iron from compounds and virulence in mice. Iron complexed or chelated with a number of metabolic organic acids, polyphosphates, and several synthetic polycarboxylic acids was readily available to all strains, even though some of the compounds used had high effective binding constants for iron and all were in 3- or 10-fold molar excess over the iron present. The addition of some of these iron-complexing substances (e.g., citrate and pyrophosphate) in iron-free form made many biologically important iron compounds that are normally inaccessible to the meningococci readily available.
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PMID:Iron acquisition by Neisseria meningitidis in vitro. 644 76

Various macromolecular substances, such as toxins and antibodies, may interfere with neuromuscular transmission. The neuromuscular junction is also known to be a site for the uptake of macromolecular substances into the axon for subsequent transport to the central nervous system. The synaptic cleft of the neuromuscular junction is separated from the rest of the extracellular compartment of muscle by the basal lamina, the permeability properties of which are not known. The penetration of macromolecular substances of varying size into the synaptic cleft of the neuromuscular junction has been studied in rats. Four different tracers: Imferon (an iron-dextran measuring 11 X 7 X 7 nm), ferritin (a spherical iron-protein 12 nm in diameter), Imposil (an iron-dextran measuring 21 X 12 X 12 nm) and colloidal gold-protein (20-25 nm in diameter) were injected into the palmaris longus muscle. Fifteen and 120 min after injection, the distribution of these particulate tracers was studied by electron microscopy. Imferon and ferritin penetrated rapidly through the basal lamina along the muscle fibres and also into the synaptic cleft of the neuromuscular junction. The larger Imposil and colloidal gold particles were restricted from penetrating the basal lamina even after 2 h, and these particles were traced only occasionally within the synaptic cleft. The results indicate that the basal lamina of muscle acts as a diffusion barrier to large macromolecules, preventing them from entering the synaptic cleft.
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PMID:The permeability of the basal lamina at the neuromuscular junction. An ultrastructural study of rat skeletal muscle using particulate tracers. 665 96

Bone marrow biopsies have been taken in 28 patients on or approaching maintenance haemodialysis before and after treatment with monthly intravenous iron-dextran (Imferon). Stainable marrow iron was compared with blood Hb, plasma ferritin, erythrocyte protoporphyrin and MCH levels at the time of biopsy, and with previous or subsequent responses to iron in terms of blood Hb and MCH. There was a positive correlation between bone marrow iron and plasma ferritin levels both before and after iron therapy. All the patients with excess marrow iron had high plasma ferritin. However, six patients with low or normal marrow iron also had high plasma ferritin, two of these before iron therapy was given. Seven of the eight patients with no detectable marrow iron had low plasma ferritin. Three of the 28 patients failed to respond to iron with an increased blood Hb. MCH increased in all patients studied during iron therapy. All but one of the patients with high plasma ferritin prior to iron therapy responded well to iron. Although a good correlation between plasma ferritin and marrow iron can be shown in dialysed patients given intravenous iron-dextran, a high plasma ferritin level in an individual patient should not by itself preclude iron therapy.
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PMID:Bone marrow iron and plasma ferritin in dialysed patients given intravenous iron-dextran. 673 97

Electron diffraction data from ferritin, iron-dextran (Imferon), ferrihydrite, and beta-FeOOH support earlier suggestions that ferritin iron and ferrihydrite are structurally the same and totally different from Imferon and beta-FeOOH, which are closely related. The conclusion that ferritin and Imferon are uniquely similar is not confirmed. Ferrihydrite-dextran complexes should make a better analog than existing iron-dextrans for the study of ferritin iron-protein interactions.
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PMID:Structural distinction between ferritin and iron-dextran (imferon). An electron diffraction comparison. 728 90

EPO treatment rapidly corrects anemia in patients with end-stage renal failure treated with hemodialysis, as long as sufficient iron is available. Absolute and relative (to demand) iron deficiency blunts the erythropoietic response and parenteral iron is frequently required during the course of therapy to restore EPO efficacy. Since the optimum time course of iron administration to restore EPO response in the short term is unknown, we compared three protocols of i.v. iron dextran administration in apparent functionally iron-deficient HD patients on oral iron therapy (hemoglobin < 10.0 g/dl plus ferritin < 100 micrograms/l and/or transferrin saturation < 20%). Intravenous iron (Imferon; Fisons Pty Ltd.) was given either as a single 600 mg dose (n = 15, Group I) or in divided doses of 100 mg administered on 6 successive dialyses (n = 14, Group II) or weekly for 6 weeks (n = 14, Group III). Response was monitored for 8 weeks. No adverse effects were observed. Collectively, mean hemoglobin increased (p < 0.01) by 0.4-0.5 g/dl plateauing at 4 weeks (between group comparison, p = 0.92). Mean ferritin concentrations changed with time (p < 0.01), peaking at 2 weeks in Groups I and II and at 4 weeks in Group III. Mean transferrin saturation levels also increased during the study (p < 0.001). The between group comparisons for the trends in iron indices were significant (p < 0.01 and 0.05 respectively). As there were no clinically significant differences in hemoglobin response at 4 weeks, single dose iron infusion would seem to be the most expedient in the short term, however frequent small doses are similarly effective.
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PMID:Comparative response to single or divided doses of parenteral iron for functional iron deficiency in hemodialysis patients receiving erythropoietin (EPO). 949 Dec 86


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