Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UNIPROT:P02794 (ferritin)
 17,525 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Three times sublethal total body X-irradiation with thymus shielding--at 2 weeks' intervals--delineated a temporarily B-cell deprived animal model, only reconstituted with recently thymus-derived cells. The thymusdependent areas of peripheral lymphoid tissue-repleted with T-cells--are described. The cellular immune capacity of these animals with an "isolated T-cell system" was analyzed by means of skin allografting. Histological and autoradiographic studies were performed in draining lymph nodes after a variety of antigenic stimuli: skin allografts, S. java vaccin, horse-gamma-globulin, horse spleen ferritin and a contact sensitizer (Oxazolone).
 ...
PMID:Histophysiology of cellular immunity reactions in B-cell deprived rabbits. An X-irradiation model for delineation of an 'isolated T-cell system'. 8 62

A novel approach for the ultrastructural localization of surface sialic acids is presented. Membrane-bound sialyl residues are chemically modified in situ by the covalent attachment of biotinyl residues, the latter of which are subsequently localized by ferritin-conjugated avidin. In contrast to previous methods, which have been based on electrostatic interactions, the above method does not affect cell surface charge. Consequently, the macromolecular configuration of the labeled sialoglycoconjugates is preserved. The method has been found to be more accurate in the quantitative evaluation and the topographical localization of membrane-based sialic acids both in normal and pathologically induced surface modulations. Modulations in cell surface sialic acid content and/or distribution have been demonstrated in beta-thalassemia and transformed lymphoid cells, and the consequences of such alterations are discussed regarding destruction vs. escape from the immune surveillance system.
 ...
PMID:Ultrastructural modulations of cell surface determinants in pathological processes. 9 32

Three times sublethal total body X-irradiation with thymus shielding--at 14 days' intervals--established an 'isolated T-cell system'. Cellular immunity reactions in draining lymph nodes of rabbits have been analyzed at the ultrastructural level after challenge with horse spleen ferritin, the chemical sensitizer, 2-phenyl-4-ethoxymethylene-5-oxazolone and after skin allografting. A basic pattern of interdigitating cells (IDC) is described as a specific constituent of the thymus-dependent areas of peripheral lymphoid tissue. Their ultrastructural features and presumable functional relationship to the afferent loop of cellular immunity reactions are presented. The differentiation pathway of two T-cell lines is shown and discussed in relation to cellular and thymus-dependent humoral immunity reactions.
 ...
PMID:Electron microscopy of cellular immunity reactions in B-cell deprived rabbits. Thymus derived antigen reactive cells, their micro-environment and progeny in the lymph node. 10 Sep 57

Tissue tolerance was induced in neonatal rats by the intravenous injection of bone marrow cells from adult allogeneic rat donors. After 6 to 8 weeks, lymphoid cells from rats in which tolerance had been induced were tested for mixed lymphocyte reactivity (MLR), 3H-uridine uptake, and the relationship of uridine incorporation to B and T lymphocytes. Lymph node (LN) and spleen (SPL) cells from the adult inoculated rats showed no reactivity in the MLR or normal lymphocyte transfer reaction (NLTRx), indicating that the animals were tolerant. After in vitro exposure to 3H-uridine, an abundance of small lymphocytes (SL) from these same tolerant rats were heavily labeled, in contrast to nontolerant controls, where relatively few SL were heavily labeled. In order to determine whether the heavily uridine-labeled cells were T cells or B cells, lymphoid cells from the LN and SPL of tolerant animals were exposed to either rabbit anti-AKR brain serum or rabbit anti-rat Ig conjugated with ferritin. The results showed that the heavily uridine-labeled SL of the tolerant rats were mainly Ig-positive cells.
 ...
PMID:3H-uridine incorporation by small lymphocytes of tolerant rats: relationship to T and B lymphocytes. 12 99

In the present paper we apply the "ecotaxis hypothesis" to the analysis of lymphocyte distribution in Hodgkin's disease and other forms of lymphoid malignancy. The results lead us to consider the possiblity that metal-binding proteins, namely ferritin, transferrin and lactoferrin, play a role in lymphocyte ecotaxopahty. It is suggested that in Hodgkin's disease, a failure of lymph node and spleen monocytes to handle iron normally could explain most of the hematologic, immunologic, pathologic, and epidemiologic features of the disease.
 ...
PMID:Suggested models of ecotaxopathy in lymphoreticular malignancy. A role for iron-binding proteins in the control of lymphoid cell migration. 30 76

The immuno-electronmicroscopic study of human EA rosettes, using ferritin-labelled anti-human IgG antiserum, showed clusters of ferritin granules at the points of contact between erythrocytes and lymphoid cells, indicating that the links between Fc fragment of IgG on the surface of erythrocytes and specific receptor on the surface of lymphoid cell correspond to the sites of morphological interaction between the 2 cell types.
 ...
PMID:Immuno-electronmicroscopic study of human EA rosettes. 31 17

A study was made of the local immune response in the udder of the sow following infusion of a soluble antigen. Four mammary glands of each of four pregnant sows were infused with ferritin prepartum. Samples of blood, colostrum, and milk were collected during the following lactation; animals were slaughtered and mammary tissue removed for immunohistology. Blood, colostrum, milk, and mammary tissues were similarly collected from nonimmunized (control) sows. Colostral and milk whey from immunized sows contained higher levels of immunoglobulins than whey from control sows. There was an increase in numbers of IgA-containing plasma cells and total lymphoid cells in mammary tissue of immunized sows compared with controls. The results suggested that the local immune response was at least as great in non-infused glands as infused glands of immunized sows.
 ...
PMID:The local immune response in the mammary gland of the sow following infusion of a protein antigen. 57 2

Lymphoid cells from blood of fetal sheep between 70 and 140 days of gestational age were examined for surface immunoglobulin (sIg) and for surface binding of horse spleen ferritin FITC and ovalbumin FITC. Fetuses of all ages had cells which bound ferritin or ovalbumin, the proportion of these cells in the lymphocyte preparations from blood decreasing with increasing age of the fetus. A similar decline in the proportion of sIg cells with age was found. The simultaneous occurrence of fetal lymphoid cells binding ferritin or ovalbumin is discussed in relation to the sIg population and to the property of the sheep fetus to respond sequentially to different antigens by the production of antibody.
 ...
PMID:Ferritin and ovalbumin binding blood lymphoid cells in fetal sheep. 84 81

Using morphologic and ultrastructural criteria, the present study in the rat was undertaken to distinguish lymphoepithelial modules from lymphoid aggregates and lymph modes, and to demonstrate the uptake and transport of ferritin and latex particles, instilled in the trachea, by the lymphoepithelium. Unlike lymph nodes or lymphoid aggregates, lymphoepithelial nodules can be distinguished by the following characteristics of the lymphoepithelium: it is flattened and devoid of goblet cells; it contains intracellular and "intercellular" vacuoles; occasional macrophage-like cells infiltrates and surrounding lymphocytes clusters can be observed. At any time, no latex particle was found inside or under the lymphoepithelium, but until 1 hour after local instillation, ferritin particles were localized close to the cilia, at the luminal surface of the epithelium, within vesicles at the surface of some cells, and in the intercellular space. Moreover, ferritin particles were consistently present on both sides of the basement membrane after 1 hour. These results suggest that lymphoepithelial nodules may be considered as original structures capable of uptake and transport across the basement membrane of certain foreign materials.
 ...
PMID:Bronchial lymphoepithelial nodules in the rat: morphologic features and uptake and transport of exogenous proteins. 92 Oct 52

The tracer proteins, horseradish peroxidase and ferritin, placed in the trachea of guinea pigs were taken up by epithelial cells and transported to the extracellular space. The interval between the introduction of the tracer proteins into the lumen of the trachea and the morphologic demonstration of the porteins in the extracellular space or within the basal portion of the cells was between 30 and 60 minutes. The proteins were transported in vesicles and no penetration of the epithelial intercellular tight junctions was found. The intercellular tight junctions were made permeable to horseradish peroxidase by anesthetic ether and this permeable epithelium was compared to the vesicle type transport. Transepithelial transport of proteins is a possible mechanism for the introduction of antigenic material into the subepithelial lymphoid tissue and this transport may also be of importance in the late onset type of asthma.
 ...
PMID:Uptake and transport of exogenous proteins by respiratory epithelium. 97 61


1 2 3 4 5 6 7 8 Next >>