Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UNIPROT:P02794 (
ferritin
)
17,525
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The effect of
ferritin
on the delayed-type hypersensitivity (DTH) response and
Arthus-type reaction
as assessed by footpad reaction using methylated human serum albumin, human serum albumin, or sheep red blood cells as antigens was investigated. Intraperitoneally administered
ferritin
was short acting and suppressed either induction or expression of DTH depending on the time of
ferritin
injection although it did not inhibit the antibody-mediated inflammatory response, the Arthus reaction. Investigation of
ferritin
's effect on the primary antibody response revealed that the number of IgG plaque-forming cells (PFC) was moderately decreased but IgM PFC were not. These results indicate that the afferent limb,
ferritin
selectively suppresses antigen presentation and/or clonal expansion of effector cells of cell-mediated immunity, but not that of the antibody response. Antigen presentation by Ia-positive cells and/or lymphokine-responsive inflammatory mononuclear cells at the efferent limb of DTH is suggested to be affected by
ferritin
. This conclusion is based upon the observations of successful TDTH effector cell transfer from sensitized but
ferritin
-treated donors and of successful reversal of
ferritin
-induced suppression of expression of DTH by supplementing normal bone marrow-derived cells containing Ia-positive ones. Thus our in vivo experimental system might be useful for the differential analysis of immunopathological lesions such as a T-cell-mediated, monocyte-dependent and an antibody-mediated inflammatory lesions.
...
PMID:Ferritin selectively suppresses delayed-type hypersensitivity responses at induction or effector phase. 295 43
