Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:P02794 (ferritin)
 17,525 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

In the introduction the author explains the term marker and its synthesis. Demands on markers are as follows: 1. strict specificity, 2. correlation with the clinical stage, 3. prognostic information. The authors discusses in more detail the problem of human choriogonadotropin, alpha-fetoprotein, basic fetoprotein and specific beta-1-glycoprotein in germinal testicular tumours. The author mentions placental alkaline phosphatase, ferritin, lactic dehydrogenase in the above tumours, in carcinoma of the prostate prostatic specific antigen, in carcinoma of the bladder oncofoetal antigens.
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PMID:[Introduction to the problem of markers in urologic oncology]. 213 39

The object of this study was to determine the known laboratory parameters, tumor markers and immunomodulatory substances in 69 ascites of various etiology, and to test their diagnostic significance. The usual parameters such as protein content, LDH ratio, albumin quotient and albumin gradient, fibronectin, cholesterol and cell count did not reliably differentiate the etiology in each particular case, although the mean values of the various groups differed significantly. Even cytological investigation was negative in 6 out of 29 malignant ascites. Neither were the immunomodulatory substances such as neopterin, beta 2-microglobulin and interleukin-2 receptors suitable for differentiation. In patients with carcinoma of the prostate the values of prostate-specific antigen were significantly increased in ascites. The best separation between benign hepatic or cardiac ascites and malignant ascites was provided by ferritin (sensitivity 97%, specificity 100%). The values in benign hepatic or cardiac ascites were lower than 150 ng/ml and those in malignant ascites higher than 170 ng/ml.
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PMID:[Tumor markers and immunomodulator substances in ascites--their value as screening and diagnosis parameters]. 247 98

The aim of the present study was to demonstrate the immunocytochemical localization of ferritin in human Leydig cells. Testes from patients orchidectomized for carcinoma of the prostate were used. The immunoreactivity for ferritin was visualized in the Leydig cells by amplification immunocytochemical technique. The Sertoli cells and some of the germ cells show moderate immunoreactivity for the examined antigen. Our result represent an immunocytochemical verification for presence of ferritin in the human Leydig cells (also in other cellular components) and suggest the role of this factor in the local auto- and/or paracrine control of the testicular functions.
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PMID:Immunoreactivity for ferritin in Leydig cells of human testis. 1258 May 27