Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:P02794 (ferritin)
 17,525 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

S-antigen- and opsin-immunoreactive sites were studied in the pineal organ of toad (Bufo bufo), frog (Rana tigrina), hedgehog (Erinaceus roumanicus) and bat (Myotis myotis) by light microscopic avidin-biotin-peroxidase and electron microscopic immunoglobulin-gold (immunogold), protein A-gold and avidin-biotin-ferritin techniques. The corresponding retinas served as reference tissues. A large number of photoreceptors of toad and frog pineal organ exhibited either strong or weak S-antigen immunoreaction in the outer segments, perikarya and basal processes. A small number of photoreceptors was S-antigen-negative. In general, the intensity of the reaction was stronger in the immunoreactive outer segments of the pineal organ than in those of the rods and certain cones of the retina. In hedgehog and bat, the perikarya and processes of the pinealocytes were either strongly or weakly S-antigen-positive or they lacked immunogold labeling. By use of an antibovine rhodopsin antiserum either strong or weak opsin immunoreactivity was found in the pineal outer segments of toad and frog. A small number of pineal photoreceptors lacked opsin antigenic sites. Double labeling with both antibovine S-antigen and antibovine opsin antisera showed that the opsin immunoreaction was present in the outer segments which also exhibited S-antigen immunoreaction. In the pineal organ of hedgehog and bat, no opsin immunoreaction was observed with the antisera used. It is proposed that in the pineal organ at least two types of photoreceptors are present: one "rod-type" elaborating rhodopsin accompanied by S-antigen and one (or two) "cone-type(s)" using an unknown photopigment(s). Obviously, the different photoreceptors enable the animal to perceive the different wavelengths of the light spectrum.
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PMID:Different types of pinealocytes as revealed by immunoelectron microscopy of anti-S-antigen and antiopsin binding sites in the pineal organ of toad, frog, hedgehog and bat. 293 52

Antigens which exist in high frequency in tumor tissues of patients with Hodgkin's disease have been obtained in relatively concentrated form by gel chromatography procedures. Further purification and analysis of these antigens performed in the present study have demonstrated that the antigen of fast electrophoretic mobility (F-antigen) is normal tissue ferritin. The identification of F-antigen as ferritin has been made on the basis of comparative physicochemical and immunological analyses of purified F-antigen and normal ferritin. Thus, F-antigen was found to contain iron and to be similar to ferritin in molecular weight, amino-acid composition, electrophoretic mobility, isoelectric distribution, and immunological reactivity. Absorption of a monospecific heterologous anti-F antiserum with normal tissue ferritin completely removed all anti-F antibody activity. Moreover, the absorption of polyspecific heterologous antiserum to crude Hodgkin's extracts, which contains antibodies reacting with F-antigen, the slower migrating S-antigen, and a third specificity present in lysates of normal peripheral blood lymphocytes (PL-antigen), with ferritin, removed only anti-F activity, thus distinguishing the S- and PL-antigens from ferritin. The existence of ferritin in high quantities in serum of Hodgkin's disease patients may provide a tool of potential diagnostic and prognostic importance in the management of this disease.
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PMID:Ferritin, a Hodgkin's disease associated antigen. 413 6