Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:P02794 (ferritin)
 17,525 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Spatone Iron-Plus is a naturally occurring mineral water from Trefriw Wells Spa in Gwynedd, Wales, UK which contains approximately 0.3 mg of iron per ml as ferrous sulphate. The water has been taken as a tonic since Victorian times. Iron absorption from Spatone Iron-Plus was measured in a whole body counter after labelling the water with [59Fe] ferrous sulphate. Absorption studies were carried out in 13 subjects. Mean absorption for 10 ml of Spatone Iron-Plus taken on an empty stomach was 23 percent. Absorption was related to body iron stores as assessed by serum ferritin. In subjects with a serum ferritin concentration of <10 mu g/I, absorption was approximately 40 percent but was <10 percent in subjects with ferritin concentrations of approximately 200 mu g/I. This study indicates that Spatone Iron-Plus provides iron in a highly bio-available form.
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PMID:Iron absorption from a natural mineral water (Spatone Iron-Plus). 911 99

Spatone Iron-Plus is a naturally occurring mineral water from Trefriw Wells Spa in Conwy County, North Wales, UK. It contains approximately 0.20 mg of iron per millilitre as ferrous sulphate and has been shown to provide iron in a highly bio-available form. A 24 ml sachet contains approximately 5 mg of iron. Iron deficiency is common in the obstetric population. However, compliance with traditional iron supplements is poor because of gastrointestinal side-effects. We designed a randomized, double-blind, placebo-controlled trial. A total of 102 low-risk antenatal patients, who were noncompliant with routinely prescribed ferrous sulphate tablets, were randomized to receive 48 ml of Spatone water or placebo. The study was conducted between 22 and 28 weeks gestation. Primary outcome measures were compliance, gastrointestinal side-effects and changes in ferritin levels during the trial period. Compliance in the intervention group was 57% compared with 67% in the control group, P = 0.22. Dyspepsia scores, as determined by a recognized and well-validated questionnaire, did not differ between the two groups. During the trial period, mean ferritin levels fell by 24% in the Spatone Iron-Plus group compared with a mean fall of 51% in ferritin levels among the control group, P = 0.016.
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PMID:A randomized trial investigating an iron-rich natural mineral water as a prophylaxis against iron deficiency in pregnancy. 1264 13

The Concanavalin A (Con A) binding capacity of plasma membranes isolated from meristematic and mature regions of four-day-old soybean (Glycine max L. Merr. cv. Wells) roots was compared. Con A binding was studied using a radiochemical assay with tritiated ((3)H)-Con A and by an electron microscope technique using Con A-ferritin (Con A-F). In both cases, plasma membranes isolated from meristematic tissue bound significantly more Con A than did corresponding membranes from mature tissue. The relative difference in reactivity, as determined by the two procedures, was approximately 49% ((3)H-Con A) and 46% (Con A-F). In contrast, K(m) values, determined from (3)H-Con A binding curves, were approximately the same, indicating that receptor sites on plasma membranes from both sources were qualitatively similar.Since Con A specifically interacts with saccharide-containing portions of membrane glycoproteins and/or glycolipids, the data suggests that there is a decrease in the concentration of those components in plasma membranes during development or that there are qualitative changes in the structure of their oligosaccharide side chains.
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PMID:A comparative evaluation of the level of concanavalin a binding by enriched plasma membrane fractions from developing soybean roots. 1666 13