Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UNIPROT:P02794 (ferritin)
 17,525 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Low serum ferritin concentrations indicating empty iron stores are common (30 to 50 per cent of the patients) in patients with carcinomas of the stomach, colon and rectum as well as in patients who have undergone resection of the stomach in addition to proximal selective vagotomy and fundoplication. Malignant diseases of the gastrointestinal tract are also associated with low serum ferritin concentrations and empty iron stores. Abnormal high serum ferritin concentrations are common in patients with polyposis of the stomach, intra-abdominal abscesses, carcinoma of the papilla of Vater, in patients one month after cholecystectomy and patients with benign tumors of the esophagus, esophagitis, perforation of peptic ulcer, diverticulitis of the colon, carcinoma of the esophagus and polyposis of the colon. Patients after proximal selective vagotomy due to duodenal ulcer have frequently lower and higher values than patients with duodenal ulcers who have not undergone operation. Thus, empty iron stores are common in patients with diseases of the gastrointestinal tract, especially ones which are malignant, and after gastric operations, whereas a few neoplasms, malignant diseases and severe infections (intraabdominal abscesses and diverticulitis of the colon) may be associated with high serum ferritin concentrations. It is highly justified to determine serum ferritin concentrations in patients with diseases of the gastrointestinal tract.
 ...
PMID:Lack of iron stores in patients with diseases of the gastrointestinal tract. 404 5

Nasal polyposis is a multifactorial disease with a strong inflammatory component. Its pathogenesis is often associated with ROS production catalysed by redox-active iron. This study aimed to characterize the roles of iron homeostasis and redox status in the pathogenesis of polyposis. Nasal polyps (NP) from asthmatics and non-asthmatics and turbinates from controls and NP-patients were analysed for ferritin, ferritin-bound iron (FBI) and levels of methionine-centred redox cycle proteins. The ferritin content in both NPs was significantly higher than in adjacent turbinates. No differences in FBI were observed between both NP groups and both turbinates groups, while in NPs it was significantly higher. In NP-turbinates the highest levels of redox proteins were observed. In conclusion, re-distribution of iron occurs upon the development of NP. While FBI is elevated in NPs, the adjacent turbinate remain iron-poor and low-inflammatory, suggesting the formation of virtual boundary between these tissues.
 ...
PMID:Iron homeostasis and methionine-centred redox cycle in nasal polyposis. 2111 Jul 82