Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:P02794 (ferritin)
 17,525 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The postoperative evaluation over two years of body iron stores by measurement of serum ferritin concentrations in 43 patients who underwent total gastrectomy, for adenocarcinoma of the stomach showed that more than 50% of the patients had depleted iron stores. The iron stores were often already depleted preoperatively and were only slightly reduced postoperatively according to the time since surgery. Total gastrectomy produced an acute and significant increase in subnormal, but not in normal or high, serum ferritin concentrations, for a period of three months. Some, although not all, patients presenting metastasis during follow-up showed an increase in serum ferritin concentrations. This study would indicate that empty iron stores are common in patients with adenocarcinoma of the stomach, that total gastrectomy produces an acute increase in subnormal serum ferritin values, but iron stores are not replaced during follow-up and that high serum ferritin concentrations are rarely seen in patients with adenocarcinoma of the stomach.
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PMID:Lack of body iron after total gastrectomy for adenocarcinoma of the stomach: a serum ferritin follow-up. 383 36

Gastric adenocarcinoma is strongly associated with Helicobacter pylori infection; however, most infected persons never develop this malignancy. H. pylori strains harboring the cag pathogenicity island (cag+), which encodes CagA and a type IV secretion system (T4SS), induce more severe disease outcomes. H. pylori infection is also associated with iron deficiency, which similarly augments gastric cancer risk. To define the influence of iron deficiency on microbial virulence in gastric carcinogenesis, Mongolian gerbils were maintained on iron-depleted diets and infected with an oncogenic H. pylori cag+ strain. Iron depletion accelerated the development of H. pylori-induced premalignant and malignant lesions in a cagA-dependent manner. H. pylori strains harvested from iron-depleted gerbils or grown under iron-limiting conditions exhibited enhanced virulence and induction of inflammatory factors. Further, in a human population at high risk for gastric cancer, H. pylori strains isolated from patients with the lowest ferritin levels induced more robust proinflammatory responses compared with strains isolated from patients with the highest ferritin levels, irrespective of histologic status. These data demonstrate that iron deficiency enhances H. pylori virulence and represents a measurable biomarker to identify populations of infected persons at high risk for gastric cancer.
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PMID:Iron deficiency accelerates Helicobacter pylori-induced carcinogenesis in rodents and humans. 2325 55