Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UNIPROT:P02794 (ferritin)
 17,525 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The present report describes a rare case of hematophagic histiocytosis associated with acute renal failure. A 32-year-old woman was referred to us from a local hospital because of progressive deterioration of renal function, jaundice and a bleeding tendency. The physical findings at admission revealed hyperemic conjunctivae, gingival bleeding, hepatomegaly, and generalized myalgia. Laboratory data indicated a decrease in platelet count, azotemia and hyperbilirubinemia. Marked elevation of serum triglycerides and ferritin was also noted. Histiocyte proliferation with phagocytosis of erythrocytes and platelets was observed in a bone marrow aspirate. A renal biopsy specimen exhibited lesions generally observed in acute tubular necrosis: degeneration and necrosis of tubular epithelial cells; round cell infiltration and edema in the interstitium; and unremarkable glomeruli. The serum titer to coxsackievirus B1 rose from < 4x at admission to 16x after recovery from the illness, suggesting that this virus may have been the causal organism of the accompanying infection. The patient's symptoms improved rapidly with supportive therapy, and complete restoration of renal function was achieved in 20 days. The morphological characteristics of the bone marrow aspirate and the clinical course were compatible with hematophagic histiocytosis.
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PMID:A case of hematophagic histiocytosis associated with acute renal failure. 833 3

The purpose of studies was: 1) an evaluation of acid-base balance parameters of capillary blood in the course of CAPD treatment with the correlation analysis between these parameters and indices of CAPD adequacy, dietary intake, nutritional status and selected clinical and laboratory findings, 2) an influence of dialysis solution containing amino acids on capillary acid-base balance. The purpose first was realized in 55 patients treated CAPD up to 24 months, the second one-in 8 CAPD patients. Kt/V, PCR, total creatinine clearance, efficacy number and clinical laboratory scores (Missouri system) were used as CAPD adequacy indices. Dietary intake was evaluated from diet histories. Indices of nutritional status included total body mass, blood concentration of total protein, albumin, Fe, ferritin and cholesterol as well as TIBC. It was shown that compensated metabolic acidosis is the most common finding in patients on CAPD. Acid-base parameters do not depend significantly on Kt/V and total creatinine clearance but there is a negative correlation between HCO3- and PCR as well as between H+ concentration and efficacy number. There is no relationship between dietary intake and acid-base parameters of CAPD patients. The worse acid-base status the greater azotemia and the higher removal of nitrogenous compounds in dialysate. It was confirmed that amino acid dialysis solution deteriorates metabolic acidosis but it can be avoided by the use of oral alkalizating drugs.
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PMID:[Parameters of blood acid: base balance and adequacy of continuous ambulatory peritoneal dialysis as well as dietary intake and nutritional status]. 1039 Oct 54

To evaluate the combined effect of age and glycemic state on circulating levels of the inflamma-miR-146a levels, 188 healthy subjects (CTR) aged 20-104 years and 144 type-2 diabetic patients (T2DM), aged 40-80 years, were analyzed. In CTR subjects, miR-146a levels showed a significant age-related decline. When a gender-stratified analysis was ran, the miR-146a age-related trajectory was confirmed only in men and a negative correlation with PAI-1, uric acid, and creatinine was also observed. In women, miR-146a circulating levels showed negative correlations with azotemia, uric acid, waist/hip ratio and ferritin. A significant miR-146a decline with aging was also observed in T2DM patients. Significant positive correlations were found between miR-146a in diabetic patients and total cholesterol, LDL-C, ApoA1, ApoB, and platelets, and negative correlations with serum iron and ferritin. Notably, miR-146a was significantly overexpressed in T2DM patients treated with metformin. MiR-146a levels were significantly lower in diabetic patients than in age-matched CTR and negatively correlated to both fasting glucose and HbA1c in males. Finally, age-related trajectories for circulating miR-146a levels showed an inverted U-shaped relationship; however, in T2DM patients the trajectory was significantly shifted towards lower levels. Our findings support the hypothesis that miR-146a could be a functional biomarker of healthy/unhealthy aging.
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PMID:Circulating miR-146a in healthy aging and type 2 diabetes: Age- and gender-specific trajectories. 3088 Jan 74