Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:P02794 (ferritin)
 17,525 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Germinal cell tumors of the testis were studied for the presence of several tumor-associated antigens. Antisera were produced by immunizing rabbits with the purified antigens of alpha-fetoprotein (AFP), carcinoembryonic antigen (CEA), and hepatoma ferritin. Indirect immunofluorescence on embryonal carcinoma with or without teratoma components demonstrated that their staining range was 1--60 per cent with antiserum against AFP, 0--16 per cent with anti-serum against ferritin, and 0-40% with antiserum against CEA. Ferritin-like substances have not been described previously in germinal tumors of the testis. No staining was seen with seminoma cells or benign testicular tissues. Raised serum levels of AFP and the ferritin-like substance were related both to the presence of tumor and to dissemination of the disease. CEA occurred transiently in serum. Eleven patients with primary tumors had no antigen in their sera and have all survived, but the median survival time for 8 patients with either antigen in preoperative sera was 12 months. Five patients with advanced tumor in whom neither AFP nor ferritin was detected had a much longer median survival time (58 mo) than did 13 patients with high levels of serum AFP or ferritin (12 mo). The presence of either AFP or ferritin in sera of patients with primary or advanced disease, therefore, seemed to indicate a poor prognosis. The determination of both substances in serum may be useful in the follow-up of patients with certain types of testicular tumors. The proportion of cells containing each antigen varied in the different tumors. Similarly, each antigen could occur independently in serum. This suggested that certain germ cell tumors contained subpopulations of cells, which differed in their production and release of the antigens studied.
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PMID:Multiple antigens as marker substances in germinal tumors of the testis. 6 76

The morphology of resected residual retroperitoneal tumour tissue from 18 patients treated with a combined chemotherapy regime for advanced testicular non-seminomatous germ cell tumours was studied. In five cases (28%) the resected tissue comprised only fibrous tissue and in ten cases (56%) only mature teratoma (T) was present. Embryonal carcinoma (EC) with yolk sac tumour (YST) differentiation was found in addition to T in one case and in two cases the resected tissue comprised pure EC. In all patients with residual T, T had also been present in the primary tumour. Resected tissue containing T was investigated for the presence of various marker proteins, including alpha-1-antitrypsin (A1 AT), carcino-embryonic antigen (CEA), ferritin (FER), lactoferrin (LF), and pregnancy-specific beta-1-glycoprotein (SP1), in addition to the well-established markers for germ cell tumours, alphafetoprotein (AFP) and human chorionic gonadotropin (HCG). AFP and HCG were present in only two cases. A1 AT and CEA were demonstrated in various amounts in epithelial structures in 11 out of 11 cases with T, while FER was found in ten and LF and SP1 in seven cases. Since A1 AT, CEA and LF were also found in the secreted material within the lumen of the teratoid structures, aspiration of cystic fluid for demonstration of these proteins in addition to AFP and HCG is recommended for diagnostic assessment. CEA and SP1 are suggested for localization and treatment of tumour tissue with the recently-developed methods using specific antibodies which are either radiolabelled or conjugated to anti-neoplastic drugs.
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PMID:Residual retroperitoneal tumour tissue in patients treated for metastatic non-seminomatous testicular germ cell tumours: an immunohistochemical investigation. 241 Sep 71

Seven tumor markers (CA125, CA19-9, TPA, IAP, CEA, ferritin, LDH) were measured in 24 patients with ovarian cancer. The positive rates in untreated cases of ovarian cancer were 87.5% for CA125, 35.5% for CA19-9, 10% for CEA, 77.8% for IAP, 63.6% for TPA, 28.6% for LDH and 35.3% for ferritin. Among these, CA125 was the most available marker for detecting tumor growth or regression during each respective clinical course by serial measurement. Serial changes in serum alpha-fetoprotein (AFP) levels during treatment were studied among 27 patients with ovarian embryonal carcinoma. AFP decreased with a half-life of about 7 days, and was restored to the normal range within 10 weeks after the initial surgery and chemotherapy (VAC) in all cases. In subsequently fatal cases, AFP rose again during 10 to 30 weeks after the initial treatment.
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PMID:[Significance of tumor markers in the treatment of patients with ovarian malignancies]. 244 93

Using an immunoperoxidase technique, a series of 13 extragonadal germ cell tumors were screened for the presence of 7 different antigens: human chorionic gonadotropin, beta-subunit (beta-hCG), pregnancy-specific beta 1-glycoprotein (SP1), human placental lactogen (hPL), carcinoembryonic antigen (CEA), alpha-fetoprotein (AFP), alpha 1-antitrypsin (alpha-AT) and ferritin. Syncytial giant cells in embryonal carcinoma and choriocarcinoma were positive for beta-hCG and SP1, while isolated foci of mononuclear cells in the embryonal carcinoma stained for AFP, alpha-AT and ferritin. Yolk sac tumor components showed immunoreactivity for AFP, alpha-AT and ferritin. In seminomas, a positive reaction for ferritin was found only in isolated cells of 2 cases. One seminoma was positive for alpha-AT. Teratomas were negative for all antigens, except for CEA and SP1 in duct-lining cells of sweat glands in one teratoma. Germ cell tumors of extragonadal sites appear to exhibit the same antigenic markers as their gonadal counterparts. Such similarities lend support to the hypothesis of a common cell origin of these neoplasms.
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PMID:Antigenic markers in extragonadal germ cell tumors. 610 Mar 61

189 orchidectomy specimens with germ cell tumours were studied for the presence of ferritin (FER) using the indirect immunoperoxidase technique. FER was demonstrated in 93% of seminomas and 90% of non-seminomas. Various epithelial cell types in embryonal carcinoma (EC), yolk sac tumours (YST) and teratoma (T) were FER positive. Carcinoma-in-situ (CIS) which was present in the seminiferous tubules adjacent to the tumours was positively stained for FER in 94% of the specimens whether the tumour was a seminoma or a non-seminoma indicating a functional relationship of CIS to seminomatous as well as to non-seminomatous germ cell tumours.
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PMID:Ferritin (FER) in testicular germ cell tumours. An immunohistochemical study. 634 53

The various histologic components of 39 germ cell tumors of the testis were studied with indirect labeled immunoperoxidase technique for the presence of the following tumor-associated antigens: alpha-fetoprotein (AFP), alpha 1-antitrypsin (A1AT), chorionic gonadotropin (HCG), specific pregnancy beta 1-glycoprotein (SP1), human placental lactogen (HPL), carcinoembryonic antigen (CEA), and ferritin (Fe). Embryonal carcinoma components were positive for AFP in 9/16, for A1AT in 6/16, for CEA in 2/16, and for Fe in 14/16. All yolk-sac tumor components were positive for AFP and Fe, and 8/13 contained A1AT and 2/13 CEA. Epithelium in teratoid components was positive for AFP in 5/14 cases, for A1AT in 8/14, for CEA in 7/14, and for Fe in 8/14. Syncytial trophoblast in choriocarcinoma components and syncytial giant cells were all positive for HCG, SP1 and HPL. In addition, tumor giant cells in two nonseminomatous tumors and in one seminoma contained HCG. Otherwise, all pure seminomas were negative for all antigens, except for Fe, which was positive in 12/16 cases. Demonstration of this functional aspect of germ cell tumors of the testis may clarify problems of classification and elucidate histogenesis. Furthermore, immunohistochemical demonstration of tumor-associated antigens is of value in the management of the patient as an indicator of which tumor markers should be used for monitoring the treatment. In addition, the presence of tumor-associated antigens may be used in prognostic evaluation.
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PMID:Distribution of tumor-associated antigens in the various histologic components of germ cell tumors of the testis. 719 54