Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UNIPROT:P02794 (ferritin)
 17,525 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The haematological parameters of 97 cases of beta thalassaemia trait and 40 cases of delta beta thalassaemia trait have been compared. No differences in haemoglobin, haematocrit, MCV, MCH, ferritin, % saturation or free erythrocyte protoporphyrin have been found. The RDW, however, is significantly increased in delta beta thalassaemia trait, its mean value (+/- SD) being 20 (2.05), even higher than that found in iron deficiency anaemia. The discrimination function described by England and Fraser may be of help in distinguishing these entities.
 ...
PMID:[Hematometric values in delta-beta thalassemia minor. Special importance of the erythrocyte distribution in comparison with beta thalassemia and iron deficiency]. 227 45

Serum erythropoietin (EPO) was measured by radioimmunoassay in 67 patients with rheumatoid arthritis (RA). Twenty of these patients judged to have iron deficiency anemia, based on reduced serum ferritin levels, had higher serum EPO levels than did the 24 other anemic patients with normal or elevated serum ferritin levels. A significant negative correlation between serum EPO and hemoglobin concentrations was noted in the former group, but not in the latter. Human recombinant erythropoietin (r-EPO) was administered to 6 anemic patients with RA, resulting in improvement of anemia in 4 patients, 2 of whom showed no change in RA activity. These findings suggest a suppressed serum EPO response ot anemia and the effectiveness of r-EPO in treating anemia associated with RA.
 ...
PMID:Suppressed serum erythropoietin response to anemia and the efficacy of recombinant erythropoietin in the anemia of rheumatoid arthritis. 221 53

Hematological parameters and free eythrocyte protoporphyrin (FEP) on a capillary blood sample were measured in 175 apparently healthy children ranging from 6 months to six years of age. Thirty eight children had hematological parameters descended and/or FEP elevated were asked to return for blood counts, FEP, serum ferritin, serum iron, total iron binding, capacity, transferrin saturation and ALA-D activity, on a venous blood sample. Only 34 children returned. Twenty seven, 15.4%, had iron stores descended or iron deficiency, 18 of them with anemia. FEP had significant correlation coefficients with hematologic parameters (p less than 0.001), serum iron and transferrin saturation (p less than 0.01). On iron deficiency anemia detection, the FEP had a sensibility and specificity of 0.94 and 0.75 respectively.
 ...
PMID:[Usefulness of the determination of free erythrocyte protoporphyrin in relation to other hematologic parameters in iron deficiency]. 227 93

The clinical efficacy and tolerability of gastroprotected ferritin were assessed in children affected by iron deficiency and/or sideropenic anemia. Forty-seven children with iron-deficiency and/or sideropenic anemia were included in the study and were treated with gastroprotected ferritin at a dose of 4-5 mg/kg/day per os for 4 months. Only 33 children correctly completed the entire treatment cycle, achieving a marked improvement of blood parameters (increased Hb, accompanied by higher levels of sideremia and in particular ferritin, with a contemporary decrease in erythrocytic protoporphyrin and transferrinemia) and clinical symptoms, especially pallor, anorexia, debility, somnolence, hyperactivity, disturbed sleep and excessive sweating. Of the remaining 14 children, 9 failed to present for the planned control after the 4 months of therapy, 3 abandoned therapy due to difficulties of assumption and 2 because of intolerance phenomena, such as nausea and diarrhoea. In conclusion, gastroprotected proteoferrin is efficacious and well tolerated in the treatment of iron deficiency in children.
 ...
PMID:[Evaluation of the effectiveness of gastro-protected proteoferrin in the therapy of sideropenic anemia in childhood]. 228 21

We have measured erythrocyte Zinc-Protoporphyrin and serum ferritin in 125 subjects: 100 seemingly healthy controls, 17 with sideropenic anemia and 8 with erythropoietic insufficiency (sideropenia without anemia). Erythrocyte Zinc-Protoporphyrin was measured using Protofluor Z (Helena--Lab.) and serum ferritin was tested with immunoenzymatic technics. Patients with sideropenic anemia showed erythrocyte Zinc-Protoporphyrin values higher than controls, whereas serum ferritin was significantly lower than controls. Patients with erythropoietic insufficiency also showed erythrocyte Zinc-Protoporphyrin values higher than controls with statistical significance whereas the decrease of serum ferritin was not significant. Our study showed that Zinc-Protoporphyrin, in conjunction with serum ferritin, is a very useful test for evaluation of iron storage.
 ...
PMID:[Zinc-protoporphyrin determination in patients with sideropenic anemia and insufficient erythropoiesis]. 229 Oct 11

Serum ferritin (SF) and erythrocyte ferritin (EF) were evaluated in 35 patients on chronic hemodialysis treatment (CHD), in 45 healthy subjects and in 22 nonnephropathic females with iron deficiency anemia. Twenty-five CHD patients with basal SF less than 500 micrograms/l were treated orally with 200 mg of Fe2+ for 2 months and the positive (hemoglobin increase greater than 1 g/dl) or negative response to the therapy was correlated to the basal levels of SF and EF. Three groups of CHD patients could be defined on the basis of their basal SF levels (hypo-, normo- or hyperferritinemic). Nine patients with increased SF levels had also EF levels significantly higher than the other CHD patients and controls since they were probably iron-overloaded. In the other 2 groups of CHD patients, EF levels were significantly higher than in controls for each level of SF probably because of the reduced utilization of iron by uremic bone marrow. Among the 25 treated CHD patients, only 5 responded to the therapy: 3 were hypoferritinemic while the other 2 responders had basal SF within the normal range. Four hypoferritinemic patients did not respond to the therapy. Four out of five responders had the lowest EF levels among CHD patients. EF measurement could be an important and useful test in detecting the presence of an iron deficiency erythropoiesis in CHD patients.
 ...
PMID:Erythrocyte ferritin in patients on chronic hemodialysis treatment. 231 39

Iron status, including S-ferritin, S-iron, S-total iron binding capacity (TIBC), TIBC saturation, haemoglobin (Hb) and dietary iron intake, was assessed in a population study comprising 92 healthy 85-year-old subjects (32 males, 60 females). S-iron, S-TIBC, TIBC saturation and S-ferritin values were not significantly different in the two sexes. Males had a geometric mean S-ferritin of 130 micrograms/l, females of 98 micrograms/l. Ferritin levels less than 15 micrograms/l (i.e. depleted iron stores) were found in one female (1.6%); and in one male (3.1%), who in addition had iron deficiency anaemia. None of the females displayed latent iron deficiency (i.e. S-ferritin less than 15 micrograms/l and S-TIBC saturation less than 15%) or iron deficiency anaemia. Arithmetic mean Hb was 145 +/- 13 (SD) g/l (9.0 +/- 0.8 mmol/l) in males and 139 +/- 11 g/l (8.6 +/- 0.7 mmol/l) in females (p less than 0.02). Median nutritional iron intake was 10 mg/day (range 3-17), higher in males (median 12) than in females (median 9) (p less than 0.0001). Iron intake showed significant correlations to S-iron, S-TIBC and TIBC saturation, but not to S-ferritin.
 ...
PMID:Serum ferritin and iron status in a population of 'healthy' 85-year-old individuals. 231 46

The iron status of 206 infants and young children in South Taiwan were evaluated by measurements of serum iron, total iron binding capacity, serum ferritin, and hematological parameters of peripheral blood including hemoglobin (Hb), hematocrit, mean corpuscular hemoglobin (MCH), and mean corpuscular volume (MCV). 18 subjects aged 2 months were included in the study and no iron deficiency was found in this group. Four groups of the other subjects aged between 3 and 36 months were studied; A: 3-6 months, 28 subjects, B: 6-12 months, 29 subjects, C: 12-24 months, 91 subjects, D: 24-36 months, 40 subjects. Prevalence of iron deficiency in those between 3 and 36 months was 34%, including iron deficiency without anemia 22.9% (n = 43) and iron deficiency anemia 11.1% (n = 21). Most cases (96.9%) of iron deficiency occurred in the infants and children aged 6-36 months. Iron deficiency without anemia in the A, B, C and D groups was 3.6%, 17.2%, 25.3%, 35.0% respectively and iron deficiency anemia were 3.6%, 17.2%, 12.1%, 10.0% respectively. Hematological parameters are less valuable in diagnosis of iron deficiency, with accuracy of 68.8%, 63.8%, 68.8%, 64.3% respectively for these four groups. These parameters decline significantly in the iron deficiency anemia group, but not in the iron deficiency without anemia group. Low levels (Hb less than 11 g/dl, hematocrit less than 33%, MCH less than 24 pg, MCV less than 72 fl) are indicators of a need to search a cause of anemia, especially iron deficiency anemia in infants and children with ages between 3 and 36 months, but normal values do not exclude iron deficiency.(ABSTRACT TRUNCATED AT 250 WORDS)
 ...
PMID:Iron status of infancy and early childhood in south Taiwan. 235 10

The prevalence of iron deficiency anemia has decreased in recent years because of improved dietary habits. Yet, iron deficiency anemia is still the most common anemia. Among mature adults, anemia of chronic disease is probably more common. Mean corpuscular volume and red cell distribution width, along with a peripheral smear examination, can often distinguish iron deficiency anemia from other common microcytic anemias, such as thalassemia minor. A normal serum iron level excludes iron deficiency anemia and indicates other causes for microcytic anemia. Often, a low serum iron level and total iron-binding capacity are due to chronic disease, and measurement of serum ferritin or a bone marrow stain for hemosiderin will be necessary to diagnose iron deficiency. Iron therapy to restore the red cell mass should be continued until iron stores are replenished.
 ...
PMID:Iron deficiency anemia. How to diagnose and correct. 240 79

In 340 bone marrow biopsies we compared ferritin, stained with an immunoperoxidase method, with hemosiderin, stained with Perls' reaction. Ferritin and hemosiderin showed the same distribution in reticuloendothelial cells. All the Perls-positive cases (n = 177) were ferritin-positive too. None of the ferritin-negative cases (n = 13) were Perls-positive. Of 163 cases with negative Perls' reaction in bone marrow, 13 (12.5%) were also ferritin-negative: these patients were mainly affected by polycythemia vera or by untreated iron deficiency anemia. Thus, immunohistochemical assessment of bone marrow ferritin can be a more sensitive tool for the evaluation of body iron stores in iron deficiency than Perls' reaction.
 ...
PMID:Immunohistochemical assessment of ferritin in bone marrow trephine biopsies: correlation with marrow hemosiderin. 246 64


<< Previous 1 2 3 4 5 6 7 8 9 10 Next >>