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Query: UNIPROT:P02794 (ferritin)
 17,525 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Iron deficiency anemia is the most frequent haematological pathology in pregnancy. Serum ferritin levels represent the state of iron deposits. Low levels are a sure sign of iron deficiency. At the University of Turin we studied the variations of serum ferritin levels during physiological pregnancy and the sensitivity of routine blood tests with respect to serum ferritin levels. Routine haematological blood values along with ferritin levels were measured in 115 patients throughout pregnancy. The mean serum ferritin level was 56 ng/ml in the first trimester, 27.2 ng/ml in the second and 11.8 ng/ml in the third. The incidences of anemia per trimester was 6.6%, 4.8% and 49% respectively (p less than 0.05, chi squared). Our results show that it is important to evaluate iron deposits early in pregnancy by measuring serum ferritin levels in order to determine the need for iron therapy.
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PMID:[Variations in ferritin levels in blood during physiological pregnancy]. 194 25

Haemoglobin and ferritin estimations employing the micro-ELISA technique were done in 308 random selected mothers in labour and their newborns. The values of haemoglobin and serum ferritin as well as birth weight and gestation of babies born to iron depleted, and mildly and moderately anaemic mothers were no different from those of newborns of non-anaemic women. However, the values of serum ferritin per se in all these newborns were much lower than what are generally reported from the western countries. Babies born to severely anaemic women, on the other hand, showed elevated levels of haemoglobin and serum ferritin, and lower birth weights and gestation. Thus, mild to moderate iron deficiency in the mother does contribute to lower iron reserves in the foetus, if not frank iron depletion, and severe iron deficiency anaemia to lower birth weight and gestation.
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PMID:Relationship of maternal serum ferritin with foetal serum ferritin, birth weight and gestation. 196 Jul 69

The blood hemoglobin concentration (B-Hb) and iron indices were measured in 1,856 consecutive female blood donors. The blood hemoglobin distribution was Gaussian except for an excess of high values. According to criteria defined by the WHO, 9.5% of the population were anemic, but using several criteria only 0.9% had iron deficiency anemia in agreement with the blood hemoglobin distribution curve. The distribution of the S-ferritin values was log Gaussian. Nearly 1/5 of female blood donors had low iron stores despite widespread use of iron supplements. The weak correlation detected between the B-Hb values and the S-ferritin level points to an increased risk of anemia in female blood donors. Regular determination of the S-ferritin level in female blood donors or extended use of iron supplements may contribute to the establishment of adequate iron stores and hence the prevention of anemia.
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PMID:[Hemoglobin concentration and iron stores in female blood donors]. 200 55

The objective of this study was to evaluate the benefit of screening for anemia in infants in relation to their previous diet. The iron status of 854 9-month old infants on 3 different feeding regimens and on a regimen including iron dextran infection was determined by analysis of hemoglobin, serum ferritin, and erythrocyte protoporphyrin levels and of serum transferrin saturation. Infants were categorized as having iron deficiency if 2 or 3 of the 3 biochemical test results were abnormal; if the hemoglobin level was 110 gm/L, then a diagnosis of iron deficiency anemia was also made. The prevalence of iron deficiency was highest in infants who were fed cow's milk formula without added iron (37.5%), intermediate in the group fed human milk (26.5%), much lower in those fed cow's milk formula with added iron (8.0%), and virtually absent in those injected with iron dextran (1.3%). The corresponding values for iron deficiency anemia were 20.2%, 14.7%, 0.6% and 0%, respectively. The use of iron supplements is therefore justified in infants who received cow's milk formula without added iron, even when there is no biochemical evidence of iron deficiency. The low prevalence of iron deficiency in the group fed iron-fortified formula appears to make it unnecessary to screen routinely for anemia in such infants. These results also support the recommendation that infants who receive human milk exclusively for 9 months require an additional source of iron after about 6 months of age.
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PMID:Iron status with different infant feeding regimens: relevance to screening and prevention of iron deficiency. 201 22

In 54 children with coeliac disease, mild iron deficiency anaemia or evidence of iron deficiency without anaemia were common at the time of diagnosis. Treatment with a gluten-free diet without iron medication eliminated all evidence of iron deficiency and completely normalized laboratory values. Subsequent challenge with gluten resulted in the rapid reappearance of suboptimal iron balance as evidenced by a decrease in serum ferritin concentration.
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PMID:Iron deficiency in coeliac disease is mild and it is detected and corrected by gluten-free diet. 203 9

Iron deficiency anaemia was detected in 23% of cases with homozygous sickle cell disease. The aetiology of iron deficiency was similar to the other population in the community. High serum ferritin level was detected in 15.4% of the cases and was well correlated to the number of transfusions. Tissue haemosiderosis was not detected in any case. Patients with heterozygous sickle cell had either normal or low serum ferritin levels.
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PMID:Iron in sickle cell disease. 146 1

Erythrocyte basic ferritin (EF) concentration was determined in 64 normal subjects, 123 patients with anemia and 12 patients with leukopenia and thrombocytopenia. There was a significant difference between males and females. Other iron indices, including plasma iron (PI), total iron binding capacity (TIBC), zinc protoporphyrin (ZnPP) and plasma ferritin (PF) were also determined in all the subjects and bone marrow iron stain was determined in the 135 patients. The lowest EF concentration was seen in patients with iron deficiency anemia, being significantly lower than that in normal subjects. EF concentration in patients with iron deficiency erythropoiesis was also lower than that in normal subjects and at the same time significantly different from that in patients with iron deficiency anemia. EF concentration increased prior to PF concentration in patients with iron deficiency anemia who had been treated for a period of 1-8 weeks. EF concentration in patients with anemia of chronic diseases had a significant difference as compared with that in normal subjects and in patients with iron deficiency anemia, but EF concentration in those patients who were accompanied by iron deficiency was similar to that in patients with simple iron deficiency anemia. EF concentration in some iron overloaded patients (aplastic anemia, megaloblastic anemia, MDS etc.) was significantly higher than that in normal subjects. It was demonstrated that there was a good correlation between EF concentration and bone marrow sideroblastic iron in the rank correlation analysis of the iron indices in 135 patients (rs 0.893, P less than 0.01). PF concentration had the best correlation with marrow iron (rs 0.948, P less than 0.01).
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PMID:[Evaluation of erythrocyte basic ferritin in the diagnosis of anemia]. 208

Blood hemoglobin, serum iron, total iron binding capacity (TIBC) and serum ferritin were measured in 140 healthy rural mapuche (southern Chile's indigenous ethnic group) infants aged 8 to 15 months: 90 had been exclusively breast fed for the first 5 or 6 months of life, then solid foods were introduced but cow's milk was never given to them. The remaining 50, which were all weaned at nearly 4 months of age and then given cow's milk and solid foods at the corresponding age, were designated as controls. Anemia was detected in 4.5% of breast fed infants and in 38% of controls. Evidence of iron deficient erythropoiesis was found in 5% and 81% of cases and controls, respectively. Human milk apparently protects this ethnic group from iron deficiency anemia and this protection seems to be better in mapuche infants than in other groups of chilean infants, because these late have shown 30% incidence of anemia around the first year of life in other studies. More studies on differences in iron nutritional state among mapuche and non mapuche are needed and are under way.
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PMID:[Iron nutrition in Mapuche infants fed with human milk (2d phase)]. 208 91

Screening for iron deficiency was offered to 485 pre-school children in one practice. A questionnaire asking for details of the child's birth, diet, medical history and social status was sent to all the families of these children. Three hundred and eleven children (64% of the total) had blood samples taken for haemoglobin concentration, mean corpuscular volume and serum ferritin levels. Fifty four of the children (17%) were iron deficient (serum ferritin less than 10 micrograms l-1 or mean corpuscular volume less than 75 fl), while 10 (3%) had iron deficiency anaemia (haemoglobin level less than 10.5 g dl-1). The prevalence of iron deficiency and iron deficiency anaemia were not significantly associated with any social class. However, there was a higher prevalence among social class 3 children than children from other social classes, 29% of them having covert iron deficiency, while 6% were frankly anaemic. As there are no ethnic minorities in the practice, dietary inadequacy was likely to be the main cause of iron deficiency. After receiving iron supplements for up to three months, all the children who were iron deficient or anaemic and attended for follow up had normalized blood values. In view of the high prevalence of iron deficiency throughout the social classes, and its association with developmental delay and behavioural disorders, screening will be offered to all children when they attend for measles, mumps and rubella immunization, and those who do not attend will be followed up.
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PMID:Prevalence of iron deficiency in rural pre-school children in Northern Ireland. 211 45

Effects of physical training on fasting erythrocyte and plasma zinc distributions were studied on seven previously sedentary male students. The training consisted of running over 5 km, 6 times/week for 10 weeks. Maximum aerobic capacity (VO2max) and 12 min walk-run performance increased significantly (p less than 0.01) after training. The erythrocyte concentrations of total zinc and of zinc derived from carbonic anhydrase I (CA-I) rose significantly (p less than 0.05) after training, whereas no such effects were noted in CA-II-derived zinc, Cu2Zn2 superoxide dismutase-derived zinc, and other zinc. On the other hand, no effect of training was found in total or alpha 2-macroglobulin-bound zinc in plasma, although albumin-bound zinc concentration declined significantly (p less than 0.05). Following the training period, however, the response to a VO2max test of the van Beaumont quotient (J Appl Physiol 1973;34:102-6) for total plasma zinc had decreased significantly (p less than 0.05), suggesting a relative reduction of the circulating exchangeable zinc. In addition, there were significant (p less than 0.05) decreases in plasma iron and ferritin concentrations after training, indicating latent iron deficiency anemia. These results may suggest that the changes in CA-I-derived zinc and/or albumin-bound zinc portend zinc deficiency during running training and that sports anemia precedes hypozincemia in athletes.
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PMID:Training effects on blood zinc levels in humans. 212 94


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