Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:P02794 (ferritin)
 17,525 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A 53-year-old woman was admitted to our hospital due to high fever, arthralgia and skin rash. Main laboratory data included the following: WBC 17,100/mm, GOT 58 U, GPT 47 U, LDH 1,510 U, ferritin 19,000 ng/ml, adenosine deaminase 79.1 U/l. She was diagnosed as having adult-onset Still's disease. Aspirin (3.0 g/day) and prednisolone (40 mg/day) were administered. All the symptoms and laboratory data improved rapidly. Adenosine deaminase, ferritin, and LDH are considered to originate mainly from the liver. Liver injury in this disease may be a primary lesion, and various serum markers may be associated with the liver abnormalities.
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PMID:Adult-onset Still's disease: hepatic involvement and various serum markers relating to the disease activity. 192 Sep 66

The distributions of erythrocyte values (red cell count, hemoglobin concentration, etc.) of healthy male workers working in a certain factory were studied in order to evaluate the usefulness of the variables as health indicators. In addition to the estimation of erythrocyte values, anamneses concerning chronic bleeding, smoking habit and alcohol consumption were questioned and serum Fe, Cu, TIBC, ferritin, plasma erythropoietin, and serum enzymes (GOT, GPT, gamma-GTP) were measured. Two-dimensional frequency distributions with axes for the red cell count and hemoglobin concentration, and frequency distributions of the score calculated from principal component analysis, showed bimodal patterns. Using nonlinear curve fitting methods, the distributions of principal component scores were fitted to a mixture of two different Gaussian distributions. The workers were then divided into two groups corresponding to the Gaussian distribution he belongs. Then the frequencies of the items and mean values of the variates were compared between them. There were no differences in the incidences of diseases that caused iron deficiencies, but the mean serum ferritin level was significantly lower in one group than in the other, in other words the workers belonging to the group with low serum ferritin level had smaller iron stores than the other. The mean serum erythropoietin level and the mean serum copper level were higher in that group than in the other. As a result, this analysis gives a new evaluation of the health status of a man who belongs to the so-called healthy male group.
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PMID:[Difference of iron stores represented in bimodal distribution of erythrocyte values among a healthy male group]. 221 98

The authors reported on a three month long EPREX (human recombinant erythropoietin) therapy of 5 hemodialysis patients for the treatment of their anemia. The drug was administered in bolus form 2 or 3 times a week after dialysis in a dose of 50 to 150 IU/bodyweight increased gradually in every (or every second) week. Hgb ad Htk values were determined once a week while erythrocyte, leukocyte, thrombocyte and reticulocyte count once a month. Serum iron, TIBC, serum ferritin, BUN, serum creatinine, urea, serum ions, liver function assays, serum lipids and amylase were also established. Hgb, Htk levels and reticulocyte count have significantly increased in the 4th week of treatment already, severe anemia ceased with improved appetite, general condition and physical strength. Serum urea and LDH levels significantly increased while SGOT decreased. No significant change in leukocyte and thrombocyte count, serum Na, K, Ca, P, Cl, BUN, creatinine, total protein level, serum albumin, bilirubin, alkaline phosphatase, GGT, GPT, amylase and blood sugar as well as serum lipid level were observed. No adverse reactions occurred during the treatment. After the three gradually decreased and within 6 weeks they had to be transfused again. In three patients the need for transfusion has significantly grown after the treatment. The authors consider EPREX a highly efficient drug in the treatment of anemia in dialysis patients.
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PMID:[Recombinant human erythropoietin in the therapy of anemia in hemodialyzed patients]. 223 36

The author found marked differences in isoferritin patterns between the ferritins of hepatocytes and Kupffer cells in normal adult rats of the Wistar strain. This fact was considered to be a phenomenon of the heterogeneities recognized widely between these two cells from the embryological, morphological and physiological viewpoint. Accordingly, the iron metabolism of hepatocytes and Kupffer cells was studied separately in cells obtained from the livers of rats which had received iron dextran previously. Especially, the concentrations of iron and ferritin and isoferritin patterns in these cells were followed by rats given the different amounts of iron (25, 50, 150 and 200 mg given to the rats) 48 hours previously and also in time course experiment (2, 10 and 30 days) by the rats given 100 mg iron. Serum iron concentration and TIBC were increased markedly 48 hours after administrations of more than 100 mg iron. However RBC count, Hb concentration and Ht showed no changes related to iron administration. In the conditions settled by the author, there were no serious increases in the serum enzyme activities of GOT, GPT, LDH and gamma-GTP. Isoferritin patterns obtained from hepatocytes and Kupffer cells maintained the same characteristics except for a slight shift to the alkaline side in each peak with the respective controls in the rats receiving 100 mg iron. In this experiment, ferritin and iron concentrations in hepatocytes and whole liver showed similarly positive increases in a dose dependent manner, while the concentrations of both compounds in Kupffer cells arrived at their maximums with 100 mg iron and were decreased by larger administrations of iron. In the time course experiment, ferritin concentration increased in hepatocytes, Kupffer cells and whole liver, and arrived at the maximum at 2 days in Kupffer cells and at 10 days in the other two specimens. However the iron concentrations reached their maximums at 2 days respectively and returned almost to the control levels afterwards in all specimens. These results indicated the characteristics of iron metabolism in two kinds of cells, and suggested the differences in the structure and the metabolism of their ferritins.
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PMID:[Iron metabolism in the hepatocytes and Kupffer cells of rats receiving large amounts of iron dextran]. 275 89

Seventy-four patients with beta-thalassemia major were studied to test the hypothesis that a deficiency of protein C (PC) and antithrombin III (AT III), both antithrombotic proteins, could contribute to the pathogenesis of CNS thromboembolic lesions. In 70 patients, PC levels were found to be significantly lower than normal, whereas AT III activity was found to be lower only in 41 patients. The lowest values of PC and AT III were found in older splenectomized patients, a low PC value only was found in chronic hepatitis patients. Prothrombin time and fibrinogen were found to be particularly abnormal in patients with chronic hepatitis and without spleen. A relatively poor correlation was observed between PC and AT III (p less than 0.02). PC correlated with age (p less than 0.001), transfusional iron (p less than 0.001) and ferritin (p less than 0.001). It also correlated with serum albumin (p less than 0.001), prothrombin time (p less than 0.001) and fibrinogen (p less than 0.02) and with serum transaminases (GPT) (p less than 0.001). The same indexes correlated less significantly with AT III activity. Nevertheless, only 2 of our patients had CNS thromboembolic complications. It is probable that low clotting factors, hyperfibrinolysis and thrombocytopenia (which are common in chronic liver disease) could have the opposite effect on hemostasis from that of low levels of anticoagulant proteins such as PC and AT III.
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PMID:Protein C and antithrombin III in polytransfused thalassemic patients. 310 18

The purpose of the study was to investigate the physiological assessment of a lacto-ovo-vegetarian diet, in comparison to a usual mixed diet and to analyse the effect of a lacto-ovo-vegetarian diet on nutritional status and blood parameters. Following an initial study, 34 resp. 33 subjects, three of them male took part in two investigation periods each lasting three weeks. During the first period (N) the subjects ingested the normal mixed diet, while in the second period (L) they were fed a lacto-ovo-vegetarian diet. The female subjects were aged 52.6 +/- 14.3 years, the male subjects 47.7 +/- 12.7 years. In both periods food supply ensued from the central kitchen of a nunnery. While preparing the meals, the food intake and the amount of nutrients was assessed with precise weighing methods. Also, the individual food consumption of the total subjects was estimated using food records. The nutritional physiological evaluation was based on the daily consumption of energy and nutrients to assess the nutrient supply, by means of the recommended dietary allowances of the German Nutrition Society. At the beginning of period N and both at the beginning and the end of period L, blood tests of the following parameters were performed: serum glucose, uric acid, and potassium, total protein, total cholesterol, HDL-, LDL-, VLDL-cholesterol, triglycerides, serum ferritin, serum iron, iron binding capacity, hemoglobin, s-GOT, s-GPT, thiamine, riboflavine, ascorbic acid. Measurements of body weight and height, body composition, skinfold thickness, circumferences, body surface, relative weight, blood pressure and sitting pulse rate completed the investigations. Furthermore, meal frequency and the daily individual energy requirement of the subjects were assessed by means of a diary of energy expenditure. On average, the daily energy consumption of women was 2020 +/- 611.3 kcal in period N, and 1970 +/- 592.4 kcal in period L. Consequently, there was a covering of energy requirements of 103% in period N and 99% in period L. Sources of energy consisted of 14% protein, 36.4% fat and 49.6% carbohydrates in period L, 13.6% protein, 39.6% fat, 44.7% carbohydrates and 2.1% alcohol in period N.
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PMID:[Effect of an ovo-lacto-vegetarian diet on nutrition and blood status. I. Method, food consumption, administration of nutrients and anthropometry]. 343 23

Liver function has been evaluated in 74 patients (aged 9 months to 19 years) with beta-thalassemia major. They were selected from 212 patients because their transaminase levels were three times higher than normal for over three months. In 36 of these subjects BSF clearance test was performed. In the majority of patients (70%) average GPT serum values were increased (66.33 +/- 35.41 U/L) while only a few of the youngest age group exhibited normal values. The transaminase level showed a direct relationship with age, ferritin level and transfusional iron. Furthermore a direct correlation was found between iron and gamma globulin levels both being related to age. Test for viral hepatitis markers showed that 60% of all the subjects studied had had HBV infection. Twenty-six of the 36 patients who underwent BSF test had normal values in the first part of the clearance curve, 8 others showed moderate changes while only the 2 remaining revealed severe alterations. The second part of the curve was abnormal in 34 and markedly altered in 2 subjects. Mean GPT serum values correlated with the first part of BSF clearance curve and BSF 45' values correlated with transfused iron. Siderosis, fibrosis, chronic inflammatory infiltration and vacuolar degeneration were seen at liver biopsy. Histological findings of chronic aggressive hepatitis were shown in two patients with high transaminase and gammaglobulin levels who had markedly abnormal BSF curve.
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PMID:[Hepatic pathology in beta-thalassemia major]. 372 17

Liver function during continuous subcutaneous deferoxamine therapy was investigated in 29 patients with homozygotic beta-thalassaemia. Average duration of treatment was 26 months (range 8-51 months). A decrease in haemosiderosis and an improvement in liver function was observed in 27 patients: Mean liver density, determined by computed tomography, decreased from 98 to 84 HU, mean serum ferritin concentration fell from 8028 to 3661 ng/ml, mean serum GOT activity from 44 to 13 U/l and GPT from 51 to 16 U/l. Mean cholinesterase activity, reflecting the improved synthetic activity of the liver, increased from 4063 to 4530 U/l.
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PMID:[Continuous subcutaneous deferoxamine treatment in thalassemia major. Decrease of hemosiderosis and improvement of liver function]. 406 38

The antioxidant defense system in liver tissue in experimental hyperthyroidism and/or in iron supplementation was investigated. Thyroid hormones (T3, T4, TSH), ferritin (marker of iron status), antioxidant status components (glutathione [GSH], glutathione peroxidase [GSH-Px], superoxide dismutase [SOD]), and serum transaminases (GOT and GPT, both of which are known to be released from damaged hepatocytes), were measured. Hyperthyroidism in rats, induced by L-thyroxine administration, significantly raised SOD activity (p < 0.05), but significantly decreased GSH-Px activity and GSH values (p < 0.001) in the liver. In the L-thyroxine administered and iron supplemented (TI) group, GSH and GSH-Px values of liver tissues were significantly lower than those of control rats (p < 0.05). GSH-Px levels of the TI group were higher (p < 0.001), and SOD levels significantly lower (p < 0.001) than those of the L-thyroxine administered group. We conclude that hyperthyroidism induces SOD activity in liver; ferritin levels increase in hyperthyroidism, contributing to the antioxidant defense system; GSH-Px and GSH levels are decreased significantly in hyperthyroidism either due to inactivation due to increased oxidative stress or to insufficient synthesis; iron supple- and GPT analysis); iron decreases the effect of T4. This must be taken into consideration during iron supplementation.
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PMID:Evaluation of antioxidant status in liver tissues: effect of iron supplementation in experimental hyperthyroidism. 1063 95

After 2 years of steroid therapy that had effectively controlled her systemic lupus erythematosus, a 37-year-old woman presented with fever, erythema (face, upper chest), and low CH50. Increased oral steroid (prednisolone from 15 mg to 40 mg) and intravenous methylprednisolone (mPSL) (80 mg for 3 days) alleviated these symptoms except for the fever. Subsequently, the patient's fever worsened and leukocytopenia, abnormal liver function, lymphadenopathy (neck, axilla), and salivary gland swelling developed. Lymph node histology revealed features characteristic of Kikuchi-Fujimoto's disease (KFD). Laboratory examinations showed WBC 600/microliter, Hb 9.5 g/dl, platelets 90,000/microliter, GOT 766 IU/l, GPT 646 IU/l, LDH 4,228 IU/l, TG 1,622 mg/dl, and ferritin 6,330 ng/ml. Serum interferon gamma was also elevated (673 U/ml). Because a bone marrow smear revealed hemophagocytosis, mPSL pulse therapy (1 g for 3 days) was started for treatment of hemophagocytic syndrome. The fever promptly disappeared, and the patient's clinical symptoms resolved within 2 weeks. The abnormal laboratory data related to KFD and hemophagocytosis returned to normal within 4 weeks after the initiation of mPSL pulse therapy. We speculated that the hemophagocytosis and salivary gland involvement in this patient were also symptoms of KFD. This case indicated that corticosteroid pulse therapy is effective for KFD with serious clinical symptoms.
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PMID:[Histiocytic necrotizing lymphadenitis (Kikuchi-Fujimoto's disease) accompanied by hemophagocytosis and salivary gland swelling in a patient with systemic lupus erythematosus]. 1069


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