Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UNIPROT:P02794 (ferritin)
 17,525 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Iron absorption from 3.38 mg 58Fe was measured in riboflavin-deficient Gambian men with haemoglobin (Hb) less than 11.5 g/dl before and after oral riboflavin therapy, and the results compared with a group not receiving riboflavin. Riboflavin status (as determined by erythrocyte glutathione reductase activation coefficient) and Hb increased in teh riboflavin-supplemented but not placebo group. Plasma ferritin levels were low and did not change in either group. There was very wide variation in percentage iron absorption between individuals and also within single individuals on two separate occasions but no measurable change with riboflavin supplementation. The results of the study indicate that the efficiency of iron utilization is impaired in riboflavin deficiency, but that iron absorption is unaffected.
 ...
PMID:Riboflavin deficiency and iron absorption in adult Gambian men. 159 Jun 70

Anemia (hemoglobin less than 110 g/L) was documented in 36 children of both sexes aged 1-12 y who were divided into two groups: malaria and other infections. The control subjects were 10 children of similar age with no anemia and without any apparent infections. Plasma ferritin concentrations (median, range) were higher in the anemic patients (203 micrograms/L, 21-5000 micrograms/L) than in control children (52 micrograms/L, 25-239 micrograms/L) although ferritin concentrations in those with malaria were still within the normal range (99 micrograms/L, 21-205 micrograms/L). In the rest of the anemic group, five patients had plasma ferritin concentrations greater than 1000 micrograms/L. There was no difference in riboflavin status between control subjects and patients or between the two anemic groups. Severity of anemia was no different between the two anemic groups either. The data indicate that riboflavin deficiency makes no contribution to the infection-induced elevation in plasma ferritin and that the contribution of malaria is smaller than that of other unidentified factors.
 ...
PMID:Plasma ferritin concentrations in anemic children: relative importance of malaria, riboflavin deficiency, and other infections. 230 51

The bioavailability of riboflavin from fortified palm juice was assessed in young adult men, Riboflavin status was assessed from urinary riboflavin excretion and erythrocyte glutathione reductase activity coefficient (EGR-AC) while iron status was assessed from haemoglobin and serum ferritin concentrations. Although the consumption of unfortified palm juice made significant contribution to the meager riboflavin intake, it conferred no metabolic advantage. The consumption of fortified palm juice produced a marked reduction in EGR-AC values and a significant increase in urinary riboflavin excretion. Since iron release from storage sites may be flavin dependent, riboflavin deficiency may affect iron utilization. Fortification may prove effective in alleviating nutrient deficiencies, but the carrier vehicle must be acceptable to all age groups.
 ...
PMID:Bioavailability of riboflavin from fortified palm juice. 263 Oct 92

Dietary histories and seven-day food records were obtained for 54 apparently healthy older adults. The two dietary methods correlated for most nutrients, but mean differences were significant for several nutrients. Intakes below recommended levels occurred most frequently for energy, calcium, and zinc. Biochemical evidence of thiamin and riboflavin deficiency was unexpectedly frequent. Using food records, dietary iron correlated with serum ferritin. Using dietary histories, dietary protein correlated with serum albumin, and dietary zinc correlated with plasma zinc. Using either dietary method, plasma ascorbate was associated positively with both dietary ascorbate and ascorbate supplements, and negatively with cigarette smoking. Use of thiamin- or folate-containing supplements was associated with improved biochemical status for the respective vitamin. Though neither dietary histories nor food records give precise intake data for individuals, either method may be useful for epidemiologic studies with appropriate sample sizes.
 ...
PMID:Comparison of dietary histories and seven-day food records in a nutritional assessment of older adults. 299 53

During gestation iron is diverted from maternal tissues to satisfy fetal requirements, but the factors controlling this transfer are not well understood. Riboflavin may be important in this process, because it is believed to be involved in the mobilization of iron from tissue ferritin. An experiment was designed to test this possibility. Female Norwegian Hooded rats were fed a riboflavin-deficient diet (B2-) from 10 wk of age through to mating and gestation. Control animals fed a complete diet (B2+) were weight-matched to the rats fed the B2- diet. At d 17 or 20 of gestation 59Fe was administered to the dam, and distribution of 59Fe between maternal, placental and fetal tissues was determined 24 h later. Iron-mobilizing activity in placental mitochondria preparations was reduced in riboflavin-deficient rats at d 18 of gestation. Riboflavin deficiency was associated with a reduction in the percentage of the radioiron dose reaching the fetal tissue at both stages of gestation. Maternal hepatic iron stores and plasma iron levels were greater in B2- dams than in controls at d 18 of gestation and showed a reduced rate of depletion over the subsequent 3 d. However, concentrations of radioiron and of ferritin iron and nonheme iron in the fetal tissues were unaffected by riboflavin status. The primary effect of riboflavin deficiency appeared to be a reduction in fetal mass, which served to limit maternal iron depletion and maternofetal iron transfer.
 ...
PMID:A study of maternofetal iron transfer in the riboflavin-deficient rat. 358 38

Young rapidly-growing weanling rats accumulate ferritin iron in the liver; riboflavin deficiency inhibits this process and is associated with reduced in vitro iron-mobilising activity at the gastro-intestinal mucosa. Adult rats that are not growing tend to maintain existing stores of iron. Whereas riboflavin deficiency reduces in vitro iron-mobilising activity at the gastro-intestinal mucosa, this has no impact on body iron stores in these animals. Levels of circulating iron, on the other hand, are significantly reduced, possibly due to some interference with iron release from the reticuloendothelial system. The magnitude of the impact of riboflavin deficiency on iron mobilisation from body stores and iron absorption may depend upon a number of factors, likely to include the size of existing hepatic iron stores and the demand for rapid iron turnover.
 ...
PMID:Investigation into the relative effects of riboflavin deprivation on iron economy in the weanling rat and the adult. 375 30

21-day-old female Norwegian Hooded rats were fed a riboflavin-deficient diet for 7 weeks. A control group consisted of individually weight-matched rats fed a complete diet. Reticulocytosis was induced by phlebotomy and heme synthesis measured in a reticulocyte-rich preparation in vitro. Concentrations of circulating iron and liver stores of ferritin iron and non-heme iron were measured. Riboflavin deficiency significantly impaired the process of accumulation and maintenance of hepatic iron stores but did not appear to influence the rate of heme synthesis in an in vitro system. A primary lesion in iron metabolism in young riboflavin-deficient rats may be at the level of iron absorption so that assimilated iron is diverted to the erythroid marrow at the expense of repleting iron stores.
 ...
PMID:Experiment to determine the effect of riboflavin deficiency at weaning on iron economy and heme synthesis. 405 48

Using female Norwegian hooded rats on controlled dietary intakes we have looked at the effects of pregnancy, and of riboflavin status, on levels of circulating iron, hepatic ferritin, iron stores and iron mobilisation in vitro from ferritin. Results suggest that pregnancy, and rapid growth, increase the demand for iron turnover, and deplete ferritin stores, and that riboflavin deficiency may impair iron mobilisation for these purposes.
 ...
PMID:Effects of pregnancy and riboflavin deficiency on some aspects of iron metabolism in rats. 650 Aug 41

Ninety preselected children, aged between 8 and 14 years, living in two rural West African (Gambian) villages, were randomly divided into three groups, matched for age and sex. One group received a placebo (lactose) tablet, one received riboflavin (5 mg) on 5 d every week, which was sufficient to correct an endemic riboflavin deficiency, and one received a multivitamin supplement (Protovit; Hoffmann La Roche), on 5 d every week, together with FeSO4 (200 mg) once weekly, and the supplements were given for 1 year. Neuromuscular tests, including arm tremor and manipulative skills, were performed on three occasions: once just before the introduction of the supplements; again 6 weeks after commencing the supplements; and again 1 year later. Venous blood samples were collected at the same time as the first two sets of neuromuscular tests. These samples were used for haematology and nutrient status indices: plasma ferritin, ascorbic acid, cyanocobalamin and pyridoxal phosphate, and erythrocyte tests for folate status, for riboflavin status (erythrocyte glutathione reductase activation coefficient) and thiamine status (erythrocyte transketolase activation coefficient). The riboflavin in both supplements achieved a clear-cut response in biochemical status, which was dose-dependent. The pyridoxine, ascorbic acid and Fe components of the multivitamin also affected the associated biochemical indices. Although overall the arm tremor and related neuromuscular function tests did not respond significantly to the supplements, significant improvement was seen in the boys for the arm-tremor test in both the supplemented groups.
 ...
PMID:Biochemical indices and neuromuscular function tests in rural Gambian schoolchildren given a riboflavin, or multivitamin plus iron, supplement. 798 90

Riboflavin deficiency in rats resulted in a reduction in the transfer of 59Fe from an intragastric dose to plasma compared to age-matched or weight-matched controls. The uptake of iron by brush-border membrane vesicles made from intestinal mucosa of riboflavin-deficient rats was much less than identically-prepared vesicles from control groups. Although the mucosal content of 59Fe was smaller in riboflavin-deficient rats thirty minutes after dosing, the relative distribution of 59Fe between the mucosal iron-binding proteins, ferritin and transferrin, was not changed compared to the control groups. These studies suggest that the impairment in iron absorption in riboflavin deficiency is primarily the result of a reduced uptake of iron into the mucosal cell and not a redistribution of iron between iron-binding proteins inside the mucosal cell.
 ...
PMID:Comparison of changes in the uptake and mucosal processing of iron in riboflavin-deficient rats. 835 36


1 2 Next >>