Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:P02794 (ferritin)
 17,525 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

We determined Placental-Leucine Aminopeptidase (P-LAP) activity, one of the oncodevelopmental antigens, in sera and in tissues of patients with gynecological cancers. The incidence of P-LAP activity and clinical usefulness of the determination of serum P-LAP activity were studied. The mean level in healthy non-pregnant sera used as controls was 6.0 +/- 2.4mg/dl/h. The mean level of P-LAP activity in patients with benign tumors such as myoma uteri and benign ovarian tumor did not increase in comparison with the controls. The mean level of P-LAP activity in patients with malignant tumor increased with advancing stages, and especially in advanced cervical and ovarian cancer, serum P-LAP levels were significantly higher than in the controls. Serum P-LAP activity correlated with the serum ferritin concentration (r=0.613), but not with the serum alpha-fetoprotein and serum carcinoembryonic antigen concentration. Serial measurements of serum P-LAP activities in patients with gynecological cancer showed that serum P-LAP activity might reflect the progress of cervical and ovarian cancer. Tissue P-LAP activities in 29 ovarian cancers were compared with those in normal tissues. Tissue P-LAP activities in 26 cases out of 29 increased to twice as high as the mean activities in 10 normal ovaries. Our present results suggest the possibility of using P-LAP activity as one of tumor markers for gynecological malignant tumors.
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PMID:[The significance of serum leucine aminopeptidase (P-LAP) determination in the gynecological malignancies]. 258 69

Sera from cancer patients specifically suppressed phosphofructokinase (fructose-6-phosphate kinase [PFK], EC 2.7.1.11), a rate-limiting enzyme in the glycolysis pathway. Among 418 cancerous sera, 68.7% evidence suppression; there was no organ specificity. Among 42 sera from early gastric cancer patients, 29 (69.0%) were positive, as were advanced gastric cancer, 14/19 (73.3%) pancreas cancer, and 75/101 (74.3%) lung cancer sera. In contrast 6/50 (12.0%) sera from patients with gastroduodenal ulcer, 3/23 (13.0%) with myoma uteri, and 0/6 with lung tuberculosis were positive. Patients with diabetes mellitus and those receiving steroid hormone therapy showed strong positive suppression. Comparative studies using other tumor markers (immunosuppressive acid protein, carcinoembryonic antigen, alpha-fetoprotein, beta 2-microglobulin, and ferritin) and the same sera used from PFK assay showed that the PFK method was two to three times more sensitive. Sephadex G-200 column chromatography revealed that the PFK-suppressive activity was retained in the postalbumin fraction. The PFK method may represent a promising new cancer screening method.
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PMID:A new cancer marker: a possible cancer screening method based on the suppression of phosphofructokinase by sera from cancer patients. 293 46

Complex echoscopic, histological and EPR- (electron paramagnetic resonance)-spectroscopic study of uterine smooth muscular tissue was performed using normal and neoplastic samples obtained from women of reproductive age as well as from experimental animals (guinea pigs) with normo- and hyperestrogenemia. It was found that as compared with normal myometrium, the proliferating uterine myoma had an extensive peripheral vascularization of myomatous nodule with a decreased resistance index, which is a marker of myocyte proliferative activity in the myomatous nodule. These data were supported by histological findings in material obtained at operations, which demonstrated the signs of proliferative growth. Using EPR, it was shown that uterine myoma was characterized by an estrogen-dependent intensification of the processes of free-radical oxidation, which correlated with a degree of hormonal changes. Accumulation of free-radical oxidation activators and of ions of ferritin-unbound iron in the tumor tissue is indicative of the intensification of proliferative activity of the cells of uterine myoma and is one of the risk factors of neoplastic growth. Hyperestrogenemia, characteristic for the myoma development, is one of the reasons for NO synthesis activation, which, in the oxidative stress, is transformed into cytotoxic peroxinitrite, contributing to further intensification of an oxidative stress and malignant transformation of tissues.
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PMID:[Oxidative metabolism of uterine smooth muscular tissue in norm and neoplastic growth (clinical and experimental studies)]. 1638 15