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Query: UNIPROT:P02794 (ferritin)
 17,525 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The gastric tolerance of ferritin has been studied in Wistar rats and compared with a conventional antianaemic product (ferrous sulphate). The oral administration of the same amount of elementary iron (10-50-100 mg/kg 3 times in 24 h) from each compound produces different anatomopathological results. The treatment with ferritin caused only a moderate gastritic process. In contrast, the administration of ferrous sulphate induced a dose-dependent progression from incipient gastritis to intense gastritis, focal haemorrhagic gastritis and focal necrotizing gastritis. Ferritin did not produce other secondary effects, and is well tolerated even at the highest dosages.
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PMID:[Histologic evaluation of gastric tolerability in rats of ferritin compared with ferrous sulfate]. 279 4

There was good parallelism between serum ferritin levels and the amount of bone marrow stainable iron in 123 patients with gastritis, gastric ulcer and duodenal ulcer. A serum ferritin concentration of about 20-25 micrograms/l is the approximate level below which stainable iron cannot be demonstrated in the bone marrow.
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PMID:A comparison between serum ferritin concentration and the amount of bone marrow stainable iron. 648 90

Serum ferritin concentrations and bone marrow stainable iron were determined in 122 adult out-patients (seventy males) with gastritis, gastric ulcer and duodenal ulcer. Half of the forty-four patients with iron deficiency (serum ferritin level below 20 micrograms/l) received peroral iron therapy (200 mg Fe++ daily). In most of the treated patients serum ferritin levels increased and the amount of bone marrow stainable iron in half of them also increased. Measurement of body iron stores by serum ferritin determinations and restoration of low body iron stores in these patients is of practical importance.
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PMID:The effect of iron treatment on serum ferritin concentrations and bone marrow stainable iron in iron deficient out-patients with gastritis, gastric ulcer and duodenal ulcer. 669 67

Circulating parietal cell antibodies (PCA) were fund in 8 (5.4%) out of 147 diabetic children screened. Both sexes were equally represented, but the titres were higher in the girls. No clear relationship between the presence of these antibodies and age or the duration of diabetes was observed. Gastric studies were performed on 8 children with PCA (group A) and 41 without PCA (group B). Both basal (BAO) and maximal acid output (MAO) were significantly (p < 0.05) lower and fasting serum gastrin elevated (p < 0.01) in group A as compared with the control group. Two patients were achlorhydric. In group B, 17 patients out of the 41 studied had hyposecretion and one achlorhydria. The result became most obvious in the group with a duration and diabetes over 10 years, where MAO was significantly diminished (p < 0.05). Gastric morphology revealed atrophic gastritis in 3 patients from seven biopsies in group A and one out five biopsies for severe hyposecretion in group B. Two other children in group A had superficial gastritis. Serum ferritin levels decreased along with the duration of diabetes. Those with gastric mucosa had the lowest values.
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PMID:Parietal cell antibodies and gastric secretion in children with diabetes mellitus. 744 98

Helicobacter pylori is a Gram-negative bacterium that infects the human gastric mucosa, causes gastritis and contributes to the development of peptic ulcers and gastric cancer. To facilitate molecular genetic analysis of this pathogen, we constructed a approximately 20-fold redundant cosmid library and physical/genetic map of strain NCTC11638. Genomic DNA fragments were cloned into the cosmid vector Lorist6, and clones were ordered by hybridization with several types of probes: (i) ends of cloned DNAs; (ii) chromosomal Notl digest fragments; (iii) cosmids containing Notl sites; and (iv) specific genes. Seven hundred and fifty-one cosmids were mapped to one of three contigs covering > 90% of the chromosome, and are represented by a 68-cosmid miniset. The order of cosmids was confirmed and extents of overlap among them were estimated by restriction analysis. All currently known H. pylori genes were mapped, including those for a cytotoxin (vacA), cytotoxin-associated protein (cagA), urease and regulatory functions (ureAb, ureD and ureH), catalase (katA), major and minor flagellins (flaA and flaB), heat-shock (stress) and chaperone proteins (dnaK, htA, hspB (groEL)), prokaryotic ferritin (pfr), an adhesin subunit (hpaA), a surface protein (26 kDa), and 16S and 23S ribosomal RNAs (two genes each). The orientations of eight genes or clusters were determined, and two repetitive sequences were also found. The gene order and rRNA gene copy number determined here differed from that reported for an unrelated strain, which suggests considerable flexibility in H. pylori genome organization.
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PMID:Ordered cosmid library and high-resolution physical-genetic map of Helicobacter pylori strain NCTC11638. 815 75

24 patients with primary biliary cirrhosis (21 female, 3 male; mean age 51 years) were examined for the occurrence of autoantibodies to gastric parietal cells (APA). APA-titers were correlated with several hematological, chemical and immunological parameters. The results of upper GI-endoscopy were available from 12 patients. APA were positive in 24/24 PBC patients. None of the endoscopies revealed evidence for type A gastritis. No pathological decrease in serum vitamin B12 was found (n = 21). Hemoglobin was either normal (n = 18) or the anemia was microcytic with low serum ferritin (n = 6). Erythrocyte MCV was < or = 97 fl in all patients. No positive correlation was found between APA and erythrocyte sedimentation rate (r = 0.13, n = 24) or the titer of antinuclear antibodies (r = -0.18, n = 24) by linear regression. Correlation coefficient between APA and total serum-Ig was 0.67 (n = 24), 0.74 between APA and serum IgM (n = 24) and 0.13 between total serum-Ig minus IgM (n = 24), indicating that APA found in PBC patients belong to the IgM-isotype. Correlation between APA and anti-M2 was 0.65 (n = 21) and between APA and antimitochondrial antibodies (AMA) 0.96 (n = 24), suggesting recognition of identical epitope(s) by APA and AMA in PBC patients. APA were consistently negative in a control group of 40 patients with various forms of chronic liver disease. We conclude that parietal cell antibodies (APA) in PBC patients seem to be of diagnostic rather than pathogenic importance. Sensitivity for PBC appears comparable to that of AMA.(ABSTRACT TRUNCATED AT 250 WORDS)
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PMID:[Parietal cell antibodies in primary biliary cirrhosis: pathogenetic or diagnostic significance?]. 820 5

Serum levels of retinol, beta-carotene, ascorbic acid, alpha-tocopherol, selenium, ferritin, copper, and zinc were assayed for approximately 600 adults aged 35 to 64 with pre-cancerous gastric lesions in an area of China with one of the world's highest rates of stomach cancer. Previous studies have shown that the cancers generally are preceded by chronic atropic gastritis (CAG), intestinal metaplasia (IM) and dysplasia. Concentrations of beta-carotene and ascorbic acid were significantly lower among individuals with IM than among those whose most severe lesion was superficial gastritis or CAG. The associations with IM for these nutrients were strong and independent. In combination, the odds of CAG progressing to IM were only 1/6 as high among those with upper tertile levels of beta-carotene and ascorbic acid as among those with lower tertile levels of both nutrients. The serum levels of beta-carotene and ascorbic acid were similar for individuals having IM with or without accompanying dysplasia. Risk of IM was also somewhat increased among those with low serum ferritin, but no significant effects were observed in multivariate analyses for the other nutrients assayed. The findings point to a major influence of specific nutrient deficits in the mechanisms of gastric carcinogenesis in this high-risk area.
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PMID:Serum micronutrients in relation to pre-cancerous gastric lesions. 831 41

Helicobacter pylori gastritis usually manifests as recurrent abdominal pain but is sometimes discovered upon evaluation for digestive tract bleeding with severe anemia. An 11-year-old who was not under medication and had no history of pain was admitted for isolated regenerative anemia (5.6 g/dl) due to digestive tract bleeding. Laboratory tests showed only low serum iron and ferritin levels. Endoscopy disclosed hemorrhagic inflammation of the duodenal cap and antritis with a hillocky appearance. The diagnosis of H. pylori infection was established on the basis of the finding of curved Gram-negative rods on the smears and of a positive urea test. There was moderate interstitial antritis. The patient was given an H2 antagonist (ranitidine) and amoxicillin with tinidazole for six weeks. Serum IgG antibodies against H. pylori were found in the child's parents and siblings, with the exception of a 7 month old infant. A ten year old sister had been hospitalized two years earlier for hemorrhagic duodenitis ascribed at the time to use of acetylsalicylic acid. H. pylori has been reported in 40% to 95% of pediatric patients with primary gastritis. Physicians should be familiar with this frequent, often familial disease. Management rests on concomitant administration of two antimicrobials and an acid secretion inhibitor to the index patient and family members. Endoscopy is too invasive to be appropriate for monitoring the outcome. In practice, recovery is affirmed on the basis of resolution of clinical manifestations and decreased levels of anti-H. pylori antibodies.
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PMID:[Helicobacter pylori gastritis manifested by acute anemia]. 835 98

Helicobacter pylori has been proposed as a major determinant in multiple gastric disorders. We describe the case of a young adult with a long-standing medical history of sideropenic anaemia and of oral iron consumption dependence with a chronic superficial H. pylori-positive gastritis. All other causes of sideropenic anaemia were carefully excluded. Histology showed a peculiar pattern of non-active H. pylori-positive gastritis. The bacterium was a non-VacA-producing strain. The first attempt at eradication caused a reduction in bacterial load and led to a partial normalization of haematologic variables without improving the ferritin level. A successful second course of eradication therapy completely reversed the anaemia and restored the iron deposit, which persisted at the 29-month follow-up. H. pylori infection can be involved in unexplained cases of iron deficiency anaemia in adults, and its cure can normalize the haematologic picture.
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PMID:Reversal of long-standing iron deficiency anaemia after eradication of Helicobacter pylori infection. 920 Feb 97

We investigated the effect of Helicobacter pylori eradication on sideropenic refractory anaemia in adolescent girls with H. pylori-associated antral gastritis without evidence of haemorrhage or clinical symptoms other than sideropenic anaemia. We conducted an open therapeutic trial in 21 adolescent girls aged 15-17 y with sideropenic refractory anaemia, which was defined as iron-deficiency anaemia refractory to oral iron therapy for 3 mo. All subjects underwent gastroduodenal endoscopy. Thirteen patients with confirmed H. pylori infection were given a 2-wk course of triple therapy and 6 wk of oral ferrous sulfate. We compared the mean levels of haemoglobin and serum ferritin among the "initial sample" (the time when the sampling was done before treatment with oral iron), "before eradication" (the time prior to triple therapy for eradication after subjects had been given oral iron for 3 mo) and "after eradication" (the time when the follow-up endoscopy was performed) data in 11 subjects in whom H. pylori infection was eradicated. Haemoglobin levels (g/dl) were 8.6+/-1.9, 8.6+/-1.4 and 11.3+/-2.3, respectively. Serum ferritin levels (microg/l) were 4.6+/-2.4, 4.2+/-2.3 and 17.5+/-6.7, respectively. After eradication of H. pylori, mean levels of haemoglobin (p = 0.0002) and serum ferritin (p = 0.0002) showed a prominent increase between "before eradication" and "after eradication". In conclusion, adolescent girls with sideropenic refractory anaemia should be evaluated for H. pylori infection. If H. pylori infection is coexistent, its eradication along with iron supplementation could correct the anaemia.
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PMID:Effect of helicobacter pylori eradication on sideropenic refractory anaemia in adolescent girls with Helicobacter pylori infection. 1070 83


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