Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:P02794 (ferritin)
 17,525 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A complex examination of 320 patients with breast tumors of varying degree of advancement was carried out. Also, the data on examination of 20 cases of fibrous-cystic mastopathy and 40 healthy females were analysed. Similar studies were conducted in 20 cases of acute and chronic osteomyelitis, 14--tuberculosis of bones and joints, 63--rheumatoid arthritis and 36--Bekhterev's disease. Pyrphotech, Tc99m; pyrophosphate, Tc99m and diphosphonate Tc99m were used in carrying out scintigraphic examination. Parathyrin, prolactin, carcinoembryonic antigen (CEA), alpha-fetoprotein and ferritin were assayed in patients' blood serum. Tumor dissemination to bones was matched by a significant rise in CEA and prolactin levels. However, these parameters were normal in patients with non-tumor skeletal pathology. No significant rise in ferritin and alpha-fetoprotein were recorded in all patients. The specificity of the said complex examination, including osteoscintigraphy and blood plasma parathyrin assays in breast cancer patients, was 79%.
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PMID:[Complex radionuclide diagnosis of tumor lesions of the bones]. 246 Sep 98

The ratio of the blood serum ferritin level and the amount of ferritin-bearing lymphocytes was determined in breast cancer patients and mastopathy patients. Direct relation between a rise of blood serum ferritin concentration, a drop in the amount of ferritin-bearing cells and tumor spreading was established in breast cancer. The maximum amount of ferritin-bearing cells was present in the blood of the patients with Stage I-IIA disease. Radical mastectomy in such patients returned the blood serum ferritin level and the amount of ferritin-bearing cells to normal.
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PMID:[Relation of blood serum ferritin and ferritin-bearing lymphocytes in breast cancer]. 395 5

We studied 127 patients. 35 patients (group I) with mastopathy disease (average 44.3 years old) included 9 patients with a breast cancer family history (subgroup I A), 26 patients without a breast cancer family history (subgroup I B) and 92 patients (group II) with a breast cancer of I-IV grade (average 49.25 years old). The results of the study revealed statistically significant higher level of CA 15-3 in serum of patients with mastopathy compared to patients with a breast cancer of I grade (p < 0.05). CA 15-3 level in patients with a breast cancer of III, IV grade in serum, was considerably higher and there was significant difference comparing to the patients with a breast cancer of I, II grade (p < 0.001) and patients with mastopathy disease. There were also higher average levels of CA 15-3 in patients with mastopathy disease with a breast cancer family history (subgroup I A) compared to patients without an oncological risk (subgroup I B), however there were not significant differences. There were also higher average levels of ferritin revealed in patients with a breast cancer of III, IV grade and which shows significant difference between patients with breast cancer of I, II grade and with mastopathy patients (p < 0.001). It seems that determination of CA 15-3 and ferritin in patients of a high risk group of a breast cancer could be a useful diagnostic tool for early determination of a breast cancer.
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PMID:[The value of evaluating tumor markers: CA 15-3 and ferritin in blood serum of patients grouped as "high risk" for breast cancer]. 1069 82