Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UNIPROT:P02774 (Gc-globulin)
 196 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

In the present study, it is shown that the pattern of the isoelectric focusing with immunofixation changes markedly in the presence of substances such as platelet extract, trypsin, chymotrypsin, vitamin D3 and neuraminidase. It has been recently found that the factor of platelet extract is actin (K. Shinomiya et al., Jpn. J. Legal Med., 36 (1982) 542-549; J. Biochem., 92 (1982) 1163-1171), and Gc globulin is bound by actin (H. Van Baelen et al., J. Biol. Chem., 255 (1980) 2270-2272). The Gc-actin complex appeared as supplementary bands of Gc-globulin near by the anode band of Gc1F-1F or Gc1S-1S. As to the Gc2-2, the supplementary band of Gc-actin complex appeared on the cathode side of the original anode band of Gc1F-1F or Gc1S-1S. Concerning Gc1F-1F (or Gc1S-1S), two supplementary bands of Gc-actin complex appeared on the anode side of the original band. Each product originated from the digestion of Gc-globulins of common phenotypes by trypsin appeared as four characteristic bands on the anode side of the original band. On the other hand, each product obtained by treatment of Gc-globulins of common phenotypes with chymotrypsin appeared as two characteristic bands on the anode side near the anode band of Gc1F-1F. The results obtained in this study give useful information to distinguish the pattern between original and supplementary bands which were altered by the action of factors.
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PMID:[Influence of the factors altering the electrophoretic migration of the alpha 2 Gc globulin in the diagram of iso-electric focusing of the Gc type]. 654 Nov 79

Two-dimensional (2-D) gel analysis was used to examine differences in the levels of 19 plasma proteins: before and after an acute inflammatory reaction (parenteral typhoid vaccination) in normal subjects, between rheumatoid arthritis (RA) patients and normals and in RA patients treated with tenidap (120 mg) and piroxicam (20 mg). Typhoid vaccination increased levels of SAA, haptoglobin alpha1, haptoglobin alpha2, haptoglobin beta and alpha1-anti-chymotrypsin but decreased transthyretin and apolipoprotein E. In RA patients, serum amyloid A (SAA), haptoglobin alpha2, haptoglobin beta, alpha1-antichymotrypsin and C3 proactivator levels were elevated while apolipoprotein A-I, apolipoprotein A-IV, transthyretin, Gc-globulin, alpha2-HS glycoprotein, alpha2-macroglobulin and alpha1-B glycoprotein levels were decreased, compared to normals. Compared to piroxicam, tenidap lowered levels of alpha1-antiprotease and SAA but raised the levels of transthyretin, Gc-globulin, alpha2-HS-glycoprotein and alpha2-macroglobulin in RA patients. C-reactive protein (CRP) could not be quantified on 2-D gels but, when measured by rate nephelometry, levels were reduced after treatment with tenidap compared to piroxicam. The general pattern of the acute phase protein response to an acute inflammatory response to typhoid vaccination is similar to that in the chronic inflammatory condition, RA. The impact of tenidap on both positive and negative acute-phase proteins in RA patients could clearly be distinguished from that of piroxicam.
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PMID:Analysis of changes in acute-phase plasma proteins in an acute inflammatory response and in rheumatoid arthritis using two-dimensional gel electrophoresis. 954 3