Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UNIPROT:P02774 (Gc-globulin)
 196 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Haptoglobin (HP), transferrin (TF), group-specific component (GC) and alpha-1-antitrypsin (PI) polymorphisms have been studied in Sardinia and the following gene frequencies have been found: HP*1 = 0.389, TF*C1 = 0.754, TF*C2 = 0.213, TF*C3 = 0.032, GC*1F = 0.193, GC*1S = 0.546, GC*2 = 0.260, PI*M1 = 0.607, PI*M2 = 0.221, PI*M3 = 0.126, PI*S = 0.040 and PI*Z = 0.006. These findings confirm the genetic uniqueness of Sardinians compared to the other Italian populations.
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PMID:Serum protein polymorphisms (HP; TF-, GC- and PI-subtypes) in Sardinia. 251 44

The distribution of alpha-1-antitrypsin (PI) and vitamin D-binding globulin (GC) phenotypes and gene frequencies has been examined in a homogenous group of clinically well-defined patients (N = 81) with rheumatoid arthritis. The distribution pattern of the two markers was then compared with two control groups consisting of 40 individuals with osteoarthritis and 192 randomly selected normal individuals, drawn from the same geographical area as the rheumatoid arthritis patients. No association was observed between alpha-1-antitrypsin subtypes or deficient alleles and any of clinical variables observed in rheumatoid arthritis cases. Although a slightly high frequency of the GC*2 allele and a low frequency of the GC*1S allele were observed in rheumatoid arthritis and osteoarthritis compared to controls, the differences were not statistically significant. However, within the patients two clinical variables were found to be significantly associated with a particular GC phenotype. Periarticular bony erosions and antinuclear antibody were positively and negatively associated with GC 1S-2 phenotype, respectively.
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PMID:Alpha-1-antitrypsin (PI) and vitamin-D binding globulin (GC) phenotypes in rheumatoid arthritis: absence of an association. 278 61

The distribution of group specific component (GC), transferrin (TF) and alpha-1-antitrypsin (PI) subtypes was determined by isoelectric focusing of plasma samples from 140 unrelated individuals belonging to the Baiga tribe of Madhya Pradesh, India. The allele frequencies observed for GC (GC*1S = 0.6742, GC*1F = 0.1326 and GC*2 = 0.1932), TF (TF*C1 = 0.7920, TF*C2 = 0.1606, TF*C3 = 0.0146 and TF*D = 0.0328) and PI (PI*M1 = 0.7179, PI*M2 = 0.1750, PI*M3 = 0.0893, PI*S = 0.0107 and PI*F = 0.0071) demonstrate appreciable heterogeneity of the Baigas compared to other populations of the region.
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PMID:Genetic variation of serum proteins (GC, TF and PI subtypes) in the Baigas of Madhya Pradesh, India. 775 74

Group-specific component (GC), transferrin (TF) and alpha-1-antitrypsin (PI) polymorphisms have been studied in the Basque population of Alava. The following gene frequencies were found: GC*1S = 0.525, GC*1F = 0.109, GC*2 = 0.366; TF*C1 = 0.793, TFC*2 = 0.171, TF*C3 = 0.032, TF*B = 0.003; PI*M1 = 0.611, PI*M2 = 0.164, PI*M3 = 0.101, PI*M4 = 0.019, PI*S = 0.101, PI*T = 0.003, PI*Z = 0.002. These results show that there is heterogeneity within the Basque population. In comparison with other populations from the Iberian Peninsula, the Basques from Alava show significant differences only for the PI system.
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PMID:Serum protein polymorphisms (GC, TF, and PI subtypes) in the Basque population of Alava. 835 14