Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UNIPROT:P02749 (beta2-glycoprotein I)
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Human Gene/Protein
beta2-glycoprotein I 15.2
THO complex subunit 7 homolog 14.2
inter-alpha-trypsin inhibitor heavy chain H3 13.6
APOH 13.2
B2GPI 13.0
NIF3L1 12.9
myosin, heavy chain 9, non-muscle 12.9
PRBP 12.2
renin binding protein 12.0
Fetuin-B 11.9
IGG1 11.9
ceruloplasmin (ferroxidase) 11.9
AT1 receptor-associated protein 11.6
intrinsic factor-cobalamin receptor 11.6
MACS1 11.5
Afamin 11.3
HLA-DRB1*1302 11.1
EMI2 11.0
B-cell CLL/lymphoma 6 10.8
fetuin B 10.7
Coagulation factor XII 10.5
GP120 10.5
succinate dehydrogenase flavoprotein subunit 10.4
orosomucoid 1 10.3
ZPI 10.2
betaTrCP 10.0
early mitotic inhibitor 1 10.0
C4BP 10.0
VPS28 9.9
glycoprotein IX 9.8
integrin beta 3 9.8
Complement protein 9.8
collagen alpha-1 9.8
PAST 9.8
coagulation factor II 9.6
Antithrombin-III 9.6
HSL1 9.5
plasma glycoprotein 9.4
GPI 9.4
apolipoprotein E receptor 2 9.4
Cubilin 9.3
Zn-alpha2-glycoprotein 9.3
annexin A5 9.3
complement component C9 9.2
Protein II 9.1
1B4 9.0
inter-alpha 8.8
SCR2 8.8
alpha 2,6-sialyltransferase 8.8
APS 8.7
LAC 8.7
SERPINC1 8.7
transcription factor SOX2 8.6
SERPING1 8.6
GP1 8.5
STIL 8.5
APOC2 8.5
Hemopexin 8.4
HNF-3beta 8.4
factor XII 8.3
C4b-binding protein 8.3
heparin-binding protein 8.3
prothrombin 8.2
EPCR 8.2
plasma protein C 8.2
histidine-rich glycoprotein 8.2
BFP 8.1
CFB 8.1
H-protein 8.1
APO 8.0
coagulation factor XIII 8.0
ZAG 8.0
APL 8.0
AP180 7.9
protein S 7.9
fibulin-1 7.8
X mRNA 7.8
cyclin B2 7.8
ENA 7.8
complement factor H 7.8
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Disease
Hughes syndrome 11.5
antiphospholipid syndrome 11.2
Primary antiphospholipid syndrome 10.2
Lupus 9.2
congenital anemia 9.2
Sneddon's syndrome 9.1
roseola 9.0
lupus 8.9
lupus 8.9
systemic lupus erythematosus 8.3
SLE 8.1
APL 8.0
IgG myeloma 7.9
habitual abortion 7.9
APL 7.9
hypoalphalipoproteinemia 7.9
locally advanced cancer 7.8
mesenteric thrombosis 7.8
hyperproteinemia 7.7
Immune thrombocytopenic purpura 7.7
cerebral thrombosis 7.7
Thrombophilia 7.6
moderate obesity 7.4
Parvovirus B19 infection 7.4
PGA 7.4
dysgraphia 7.2
APL 7.1
Relapsing polychondritis 7.1
superficial thrombophlebitis 7.0
dyscalculia 6.9
Mediterranean spotted fever 6.9
Proteus syndrome 6.8
syphilis 6.7
thrombocytopenia 6.4
Deep vein thrombosis 6.2
inflammatory joint disease 6.2
polyarthralgia 6.1
Optic nerve 6.0
scarlet fever 6.0
vascular obstruction 6.0
cryoglobulinemia 6.0
borderline hypertension 6.0
Behcet's disease 5.9
autoimmune disease 5.9
abnormal involuntary movements 5.9
mixed connective tissue disease 5.9
Sjogren's syndrome 5.9
rheumatism 5.7
deep vein thrombosis 5.7
connective tissue disease 5.7
Plasmodium falciparum infection 5.7
thrombophlebitis 5.6
carotid artery stenosis 5.5
DVT 5.5
infectious mononucleosis 5.5
HDL3 5.5
DM2 5.5
acute monocytic leukemia 5.4
Buerger's disease 5.4
ischemic colitis 5.4
abortion 5.2
polyarteritis nodosa 5.2
Thrombus 5.1
aortitis 5.1
lupus nephritis 5.0
intermittent claudication 5.0
skin ulcers 5.0
eclampsia 5.0
preeclampsia 5.0
polymyalgia rheumatica 5.0
chronic urticaria 5.0
IMT 4.9
Churg-Strauss syndrome 4.9
hemolytic anemia 4.9
HSP 4.9
APC 4.9
atherosclerosis 4.9
EIA 4.7
cerebral infarction 4.7
autoimmune thyroid disease 4.6
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Symptom
Climacteric symptoms 10.3
livedo 9.1
impaired motor coordination 7.6
chorea 6.2
consciousness disturbance 5.5
hypoproteinemia 5.1
arthralgia 4.0
cerebellar ataxia 3.4
lethargy 2.7
hemoptysis 2.6
regurgitation 2.2
dizziness 2.0
respiratory distress 2.0
splenomegaly 1.9
constipation 1.9
angina 1.8
Ill 1.8
erythema 1.5
dyspnea 1.4
tremor 1.0
overweight 0.5
seizures 0.5
abdominal pain 0.3
diarrhea -0.6
pain -1.8
Drug
Kaolin 9.6
GNA 7.1
Phosphatidylserine 6.8
Galactose 6.8
Eculizumab 6.8
Serum albumin 4.9
IL-1ra 4.8
Bayer 4.6
DM1 4.6
Docetaxel 4.4
uPA 4.2
CaCl2 4.2
CaCl2 4.2
CaCl2 4.1
Asn 4.0
Silica 4.0
Albumin 4.0
Fluorescein 3.8
ADM 3.6
Fluorescein 3.3
ROC 3.3
lysine 2.7
THF 2.2
nitroglycerin 2.1
Nephron 1.7
IFN-gamma 1.4
IL-2 0.4
CSF 0.3
Dermatol -1.8
Enzyme
GP-I 10.9
pregnancy-associated plasma protein-A 7.5
APC 7.0
proteinase-3 6.8
thromboplastin 6.7
lysyl endopeptidase 6.3
Hageman factor 6.2
factor C 5.9
ceruloplasmin 5.9
polo-like kinase 1 5.6
lipoprotein lipase 5.2
methylenetetrahydrofolate reductase 5.2
methylenetetrahydrofolate reductase 5.2
proprotein convertase 5.1
thrombin 5.1
lecithin:cholesterol acyltransferase 5.0
Thy1 5.0
plasmin 4.9
peroxiredoxin 4.8
sialyltransferase 4.6
apyrase 4.6
sialyltransferase 4.6
sialyltransferase 4.6
thyroid peroxidase 4.6
paraoxonase 4.5
MEKK1 4.4
paraoxonase 4.2
chaperonin 4.1
tissue plasminogen activator 4.1
kallikrein 3.7
glyceraldehyde-3-phosphate dehydrogenase 3.1
subtilisin 3.1
glyceraldehyde-3-phosphate dehydrogenase 3.1
glyceraldehyde-3-phosphate dehydrogenase 3.0
phospholipase A2 3.0
urokinase-type plasminogen activator 2.8
glyceraldehyde-3-phosphate dehydrogenase 2.8
caspase-1 2.6
cholinesterase 2.6
glyceraldehyde-3-phosphate dehydrogenase 2.5
papain 2.5
ribonuclease 2.5
ribonuclease 2.5
neuraminidase 2.4
carbonic anhydrase 2.4
cdc2 2.2
elastase 2.1
transcriptase 2.0
proteasome 2.0
NADPH oxidase 1.9
trypsin 1.9
peroxidase 1.8
chymotrypsin 1.8
NADPH oxidase 1.8
RNase 1.2
calcineurin 1.2
RNase 1.1
phospholipase C 1.0
endonuclease 1.0
luciferase 1.0
adenylate cyclase 1.0
alkaline phosphatase 0.7
alanine aminotransferase 0.5
acetylcholinesterase 0.4
RNA polymerase 0.1
renin 0.1
ERK -0.3
mitogen-activated protein kinase -0.3
ATPase -0.8
Compound
PAPS 8.3
APS 8.0
Factor X 7.3
Pantothenate 7.2
nonanoic acid 7.1
nonanoic acid 7.1
nonanoic acid 7.1
nonanoic acid 7.0
Factor H 7.0
APO 6.8
Phosphatidylserine 6.8
Galactose 6.7
MCE 6.6
nonanoic acid 6.4
Hydroxychloroquine 6.3
H-3 6.2
Valine 6.2
N-hydroxysuccinimide ester 6.1
Sialic acid 6.1
Fenofibrate 6.0
GGG 5.9
Plasmin 5.6
DPC 5.6
DPC 5.6
Warfarin 5.4
Nodular 5.4
PCI 5.3
phthalaldehyde 5.3
POPC 5.2
CHAPS 5.0
Neu5Ac 4.9
Pro-Gly 4.8
Docetaxel 4.8
GAL 4.6
GalNAc 4.5
Biotin 4.5
GM2 4.5
ubiquinol 4.5
LPC 4.4
1-propanol 4.3
GlcNAc 4.3
Tween 20 4.3
COS 4.2
Thrombin 4.1
ANA 4.1
ANA 4.1
CaCl2 4.1
GM3 4.1
Heparin 4.1
Fibrin 4.1
HgCl2 4.1
homocysteine 4.0
coenzyme Q10 4.0
Leucine 4.0
GPT 4.0
Nitrite 4.0
PNA 4.0
TOF 3.9
THP 3.9
THP 3.8
PAP 3.8
PPD 3.7
Nitrite 3.7
AAA 3.7
PPD 3.6
Estrogen 3.6
PAP 3.6
PAP 3.6
trifluoroacetic acid 3.5
trifluoroacetic acid 3.5
trifluoroacetic acid 3.5
trifluoroacetic acid 3.5
PAP 3.5
trifluoroacetic acid 3.5
THE 3.2
serine 3.1
thiourea 3.0
MgCl2 3.0
valine 3.0
AMPA 3.0
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