Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UNIPROT:P02749 (beta2-glycoprotein I)
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Human Gene/Protein
beta2-glycoprotein I 15.2
THO complex subunit 7 homolog 14.2
inter-alpha-trypsin inhibitor heavy chain H3 13.6
APOH 13.2
B2GPI 13.0
NIF3L1 12.9
myosin, heavy chain 9, non-muscle 12.9
PRBP 12.2
renin binding protein 12.0
Fetuin-B 11.9
IGG1 11.9
ceruloplasmin (ferroxidase) 11.9
AT1 receptor-associated protein 11.6
intrinsic factor-cobalamin receptor 11.6
MACS1 11.5
Afamin 11.3
HLA-DRB1*1302 11.1
EMI2 11.0
B-cell CLL/lymphoma 6 10.8
fetuin B 10.7
Coagulation factor XII 10.5
GP120 10.5
succinate dehydrogenase flavoprotein subunit 10.4
orosomucoid 1 10.3
ZPI 10.2
betaTrCP 10.0
early mitotic inhibitor 1 10.0
C4BP 10.0
VPS28 9.9
glycoprotein IX 9.8
integrin beta 3 9.8
Complement protein 9.8
collagen alpha-1 9.8
PAST 9.8
coagulation factor II 9.6
Antithrombin-III 9.6
HSL1 9.5
plasma glycoprotein 9.4
GPI 9.4
apolipoprotein E receptor 2 9.4
Cubilin 9.3
Zn-alpha2-glycoprotein 9.3
annexin A5 9.3
complement component C9 9.2
Protein II 9.1
1B4 9.0
inter-alpha 8.8
SCR2 8.8
alpha 2,6-sialyltransferase 8.8
APS 8.7
LAC 8.7
SERPINC1 8.7
transcription factor SOX2 8.6
SERPING1 8.6
GP1 8.5
STIL 8.5
APOC2 8.5
Hemopexin 8.4
HNF-3beta 8.4
factor XII 8.3
C4b-binding protein 8.3
heparin-binding protein 8.3
prothrombin 8.2
EPCR 8.2
plasma protein C 8.2
histidine-rich glycoprotein 8.2
BFP 8.1
CFB 8.1
H-protein 8.1
APO 8.0
coagulation factor XIII 8.0
ZAG 8.0
APL 8.0
AP180 7.9
protein S 7.9
fibulin-1 7.8
X mRNA 7.8
cyclin B2 7.8
ENA 7.8
complement factor H 7.8
Fibrinopeptide A 7.8
apolipoprotein CII 7.7
APOC1 7.7
CRL 7.7
hemopexin 7.7
anaphase-promoting complex/cyclosome 7.7
factor H 7.6
complement receptor type 1 7.6
Apo(a) 7.6
Gc-globulin 7.6
protein C 7.6
protein Z 7.6
Megalin 7.6
apoptosis-associated speck-like protein containing a CARD 7.5
apolipoprotein M 7.5
AHS 7.5
serglycin 7.4
proteoglycan core protein 7.4
factor V Leiden 7.4
pancreatic stone protein 7.4
alpha-2-macroglobulin 7.4
AMBP 7.4
Protein C 7.4
securin 7.4
apolipoprotein D 7.3
annexin A2 7.3
mitogen-activated protein kinase kinase 1 7.3
sIL-6R 7.3
vitamin D-binding protein 7.3
complement component C3 7.3
platelet-activating factor acetylhydrolase 7.3
apolipoprotein C-II 7.2
coagulation factor V 7.2
tetranectin 7.2
apolipoprotein A-IV 7.2
apo AII 7.1
cubilin 7.1
PDIA3 7.1
Factor XII 7.1
interleukin 2 receptor 7.1
complement component 3 7.0
Prothrombin 7.0
tissue factor 7.0
megalin 7.0
factor Xa 7.0
thrombospondin 1 7.0
aldolase B 7.0
autoantigen 6.9
complement protein 6.9
APE 6.9
Paraoxonase 6.9
thyroxine-binding prealbumin 6.9
NGT 6.9
factor XI 6.9
low density lipoprotein receptor 6.8
alpha2-macroglobulin 6.8
SDHA 6.8
PCI 6.7
ABG 6.7
haptoglobin 6.7
VH3 6.7
Rheumatoid factor 6.7
thromboplastin 6.7
alpha-1-antichymotrypsin 6.7
EXP 6.7
annexin V 6.7
C3b inactivator 6.6
prealbumin 6.6
SS-A 6.6
decay accelerating factor 6.6
tissue factor pathway inhibitor 6.6
gelsolin 6.5
TGC 6.5
factor V 6.5
40 kDa) 6.5
APOC3 6.4
endocytic receptor 6.4
Hageman factor 6.4
Ceruloplasmin 6.4
p26 6.4
ADAMTS-13 6.4
ApoA-I 6.4
DP1 6.4
NTCP 6.4
lipopolysaccharide-binding protein 6.4
MPL 6.3
lactadherin 6.3
NS-1 6.3
Polo-like kinase 6.3
A-II 6.3
Plasmin 6.3
MAP2K1 6.3
YKL-40 6.3
IGF I 6.3
p185 6.3
alpha 1-antitrypsin 6.3
mu2 6.2
BP1 6.2
Polo-like kinase 1 6.2
Cr2 6.2
Thrombomodulin 6.2
annexin II 6.2
fetuin-A 6.2
S protein 6.2
BF2 6.1
Cyclin B1 6.1
C4B 6.1
complement receptor 6.1
pseudocholinesterase 6.1
decay-accelerating factor 6.1
factor B 6.1
CAPS 6.1
PF4 6.0
ceruloplasmin 6.0
Apolipoprotein E 6.0
apolipoprotein A-I 6.0
PON 6.0
alpha1-acid glycoprotein 5.9
annexin A1 5.9
antithrombin 5.9
SNA 5.9
Protein S 5.9
serum protein 5.9
glycoprotein 5.9
Chymotrypsin 5.8
CDR1 5.8
platelet-derived 5.8
p18 5.8
apolipoprotein 5.8
Major histocompatibility complex 5.8
dilute 5.7
PON1 5.7
leukocyte common antigen 5.6
apolipoprotein A1 5.6
glycophorin 5.6
ARA 5.6
CD41 5.6
PLK1 5.6
cryptic 5.6
alpha-1-antitrypsin 5.5
neurogranin 5.5
thyroid peroxidase 5.5
IgA 5.5
interleukin 12 5.5
lamin A/C 5.5
arylesterase 5.5
functional) 5.4
Hsp60 5.4
interleukin-18 5.4
DM2 5.4
beta-thromboglobulin 5.4
small nuclear ribonucleoprotein 5.4
B19 5.4
brain protein 5.4
lipoprotein lipase 5.4
apolipoprotein E 5.3
thrombomodulin 5.3
IL-1ra 5.3
insulin-like growth factor II 5.3
PtdIns 5.3
P-selectin 5.3
APC 5.2
methylenetetrahydrofolate reductase 5.2
ADAMTS13 5.2
HSP 5.2
factor VII 5.2
ubiquitin ligase 5.2
GPIIIa 5.2
CS2 5.1
P protein 5.1
CD99 5.1
CD47 5.1
amphiregulin 5.1
mannose-binding lectin 5.0
thrombin 5.0
apyrase 5.0
Neuraminidase 5.0
GPIIb 5.0
TFIID 5.0
CCT 5.0
GPIb 5.0
CR1 5.0
transthyretin 5.0
apoE 5.0
tetraspanin 5.0
factor IX 4.9
plasminogen 4.9
CD40 ligand 4.9
antichymotrypsin 4.9
low-density lipoprotein receptor 4.9
rheumatoid factor 4.9
Transcription factor 4.8
GATA3 4.8
ANA 4.8
placental growth factor 4.8
plasminogen activator inhibitor 4.8
cyclin B1 4.8
SSB 4.8
vWF 4.8
fractalkine 4.7
Fc gamma 4.7
Lp(a) 4.7
CD9 4.7
A-I 4.7
paraoxonase 4.7
HLA-DQ 4.7
CR3 4.7
vascular endothelium 4.6
sialyltransferase 4.6
CAL 4.6
LDL receptor 4.6
angiotensinogen 4.6
heavy chain 4.6
N-acetyl-beta-D-glucosaminidase 4.6
non-catalytic 4.5
CD21 4.5
beta-casein 4.5
DM1 4.5
NS5 4.5
stromelysin 4.5
cyclin D 4.4
C1 inhibitor 4.4
A-1 4.4
CD40 4.4
SSA 4.4
AP-2 4.4
SCF 4.4
antithrombin III 4.4
C-reactive protein 4.3
fibrinogen 4.3
CD40L 4.3
CD29 4.3
platelet factor 4 4.3
CRP 4.3
Fc receptor 4.3
retinol-binding protein 4.3
alpha-chain 4.3
clusterin 4.3
serum amyloid A 4.2
Albumin 4.2
more...
Disease
Hughes syndrome 11.5
antiphospholipid syndrome 11.2
Primary antiphospholipid syndrome 10.2
Lupus 9.2
congenital anemia 9.2
Sneddon's syndrome 9.1
roseola 9.0
lupus 8.9
lupus 8.9
systemic lupus erythematosus 8.3
SLE 8.1
APL 8.0
IgG myeloma 7.9
habitual abortion 7.9
APL 7.9
hypoalphalipoproteinemia 7.9
locally advanced cancer 7.8
mesenteric thrombosis 7.8
hyperproteinemia 7.7
Immune thrombocytopenic purpura 7.7
cerebral thrombosis 7.7
Thrombophilia 7.6
moderate obesity 7.4
Parvovirus B19 infection 7.4
PGA 7.4
dysgraphia 7.2
APL 7.1
Relapsing polychondritis 7.1
superficial thrombophlebitis 7.0
dyscalculia 6.9
Mediterranean spotted fever 6.9
Proteus syndrome 6.8
syphilis 6.7
thrombocytopenia 6.4
Deep vein thrombosis 6.2
inflammatory joint disease 6.2
polyarthralgia 6.1
Optic nerve 6.0
scarlet fever 6.0
vascular obstruction 6.0
cryoglobulinemia 6.0
borderline hypertension 6.0
Behcet's disease 5.9
autoimmune disease 5.9
abnormal involuntary movements 5.9
mixed connective tissue disease 5.9
Sjogren's syndrome 5.9
rheumatism 5.7
deep vein thrombosis 5.7
connective tissue disease 5.7
Plasmodium falciparum infection 5.7
thrombophlebitis 5.6
carotid artery stenosis 5.5
DVT 5.5
infectious mononucleosis 5.5
HDL3 5.5
DM2 5.5
acute monocytic leukemia 5.4
Buerger's disease 5.4
ischemic colitis 5.4
abortion 5.2
polyarteritis nodosa 5.2
Thrombus 5.1
aortitis 5.1
lupus nephritis 5.0
intermittent claudication 5.0
skin ulcers 5.0
eclampsia 5.0
preeclampsia 5.0
polymyalgia rheumatica 5.0
chronic urticaria 5.0
IMT 4.9
Churg-Strauss syndrome 4.9
hemolytic anemia 4.9
HSP 4.9
APC 4.9
atherosclerosis 4.9
EIA 4.7
cerebral infarction 4.7
autoimmune thyroid disease 4.6
transient ischemic attack 4.6
acute promyelocytic leukemia 4.6
hyperhomocysteinemia 4.5
pulmonary embolism 4.5
adrenal insufficiency 4.5
hyperlipoproteinemia 4.5
anovulation 4.5
polyarthritis 4.5
autoimmune hemolytic anemia 4.4
arteriopathy 4.4
esophageal varices 4.4
Endothelial dysfunction 4.3
mimicry 4.3
parvovirus 4.3
cardiovascular risk factor 4.3
coagulopathy 4.3
thrombocytopenic purpura 4.2
Q fever 4.1
macroglobulinemia 4.1
rheumatic fever 4.1
left ventricular failure 4.1
neurological disease 4.1
Takayasu 4.0
tumor vasculature 4.0
alcoholic cirrhosis 4.0
primary biliary cirrhosis 4.0
cerebral ischemia 4.0
myelitis 4.0
primary sclerosing cholangitis 3.9
Age-related macular degeneration 3.9
STS 3.9
vasculitis 3.9
CNS diseases 3.9
leprosy 3.9
hairy cell leukemia 3.8
Schmidt 3.8
optic neuritis 3.8
hemoglobinopathies 3.8
leg ulcers 3.8
arteriosclerosis 3.8
degenerative disease 3.7
vascular disease 3.7
disseminated intravascular coagulation 3.7
ARF 3.7
proteinuria 3.7
hypercholesterolemia 3.7
AAA 3.7
heart block 3.6
gastrointestinal disease 3.6
unstable angina 3.6
giant cell arteritis 3.6
Japanese encephalitis 3.5
polymyositis 3.5
rash 3.5
idiopathic thrombocytopenic purpura 3.5
Wegener's granulomatosis 3.5
Plaque 3.4
von Willebrand disease 3.4
cholecystitis 3.4
gangrene 3.3
Helicobacter pylori infection 3.3
microalbuminuria 3.2
Giant 3.2
erythroleukemia 3.2
photosensitivity 3.2
hyperprolactinemia 3.2
acute renal failure 3.2
EBV infection 3.2
lymphoproliferative disorders 3.2
DM1 3.2
plaque 3.1
movement disorder 3.1
typhoid 3.1
portal hypertension 3.1
myocardial infarction 3.0
PCA 3.0
MAS 3.0
leiomyosarcoma 3.0
brain atrophy 3.0
renal cancer 2.9
chronic bronchitis 2.9
pancytopenia 2.9
diplopia 2.9
acute hepatitis 2.9
stroke 2.8
hepatitis B 2.8
PSS 2.8
hepatitis C 2.8
migraine 2.8
scleroderma 2.7
rheumatoid arthritis 2.7
uremia 2.7
Epstein 2.7
Evans 2.6
renal impairment 2.6
Shigella 2.6
infertility 2.5
urticaria 2.5
hepatitis A 2.5
hemiparesis 2.5
NOD 2.5
nephritis 2.5
aphasia 2.5
dyslipidemia 2.5
cirrhosis 2.4
STD 2.4
Lyme disease 2.4
leukopenia 2.4
respiratory failure 2.4
myasthenia gravis 2.3
chronic renal failure 2.3
renal disease 2.3
arthritis 2.3
polyneuropathy 2.3
polycystic ovary syndrome 2.3
coronary heart disease 2.3
hyperlipidemia 2.3
irritable bowel syndrome 2.2
arthropathy 2.2
diabetic retinopathy 2.2
mitral regurgitation 2.2
periodontal disease 2.2
multiple sclerosis 2.1
abdominal aortic aneurysm 2.1
varicella 2.1
malaria 2.1
Graves' disease 2.1
multiple myeloma 2.1
pulmonary hypertension 2.0
retinopathy 2.0
chronic hepatitis 1.9
nephrotic syndrome 1.9
SDS 1.9
thalassemia 1.9
liver disease 1.9
infectious diseases 1.9
Syndrome 1.8
mole 1.8
NHS 1.8
gallstones 1.8
cardiovascular disease 1.8
endometriosis 1.8
respiratory disease 1.8
coronary artery disease 1.8
gastroenteritis 1.7
alcohol abuse 1.7
type 2 diabetes 1.7
inflammatory bowel disease 1.7
prolapse 1.7
urinary tract infection 1.7
metabolic syndrome 1.7
Brown 1.6
periodontitis 1.6
tetanus 1.6
epilepsy 1.6
sarcoidosis 1.5
Huntington's disease 1.5
non-Hodgkin's lymphoma 1.5
diabetes 1.5
myelopathy 1.4
bipolar disorder 1.4
hepatocellular carcinoma 1.4
glomerulonephritis 1.4
malnutrition 1.4
essential hypertension 1.4
dengue 1.4
hepatitis 1.3
myocardial ischemia 1.3
pancreatitis 1.3
blindness 1.2
hypertension 1.2
heart disease 1.2
ulcerative colitis 1.1
sepsis 1.1
Best 1.1
mole 1.1
graft-versus-host disease 1.1
chronic disease 1.1
encephalitis 1.0
HIV 1.0
sepsis 0.9
primary tumor 0.9
psoriasis 0.9
type 1 diabetes 0.9
cardiomyopathy 0.9
Crohn's disease 0.8
confusion 0.8
Klebsiella 0.8
non-small cell lung cancer 0.8
adenocarcinoma 0.7
neuropathy 0.7
lung carcinoma 0.7
congestive heart failure 0.7
anemia 0.5
acute myocardial infarction 0.5
pneumonia 0.5
dementia 0.4
hyperglycemia 0.4
chronic obstructive pulmonary disease 0.4
ischemia 0.3
obesity 0.3
fits 0.3
renal failure 0.3
acute myeloid leukemia 0.1
immunodeficiency 0.1
lung cancer 0.1
tumor progression -0.1
squamous cell carcinoma -0.2
SEM -0.3
virus infection -0.4
metastases -0.4
Alzheimer's disease -0.5
influenza -0.6
tumor growth -0.6
AIDS -0.7
carcinogenesis -0.8
heart failure -0.9
lymphoma -0.9
cancer -0.9
tuberculosis -1.0
breast cancer -1.1
asthma -1.2
tumor -1.2
carcinoma -2.0
Symptom
Climacteric symptoms 10.3
livedo 9.1
impaired motor coordination 7.6
chorea 6.2
consciousness disturbance 5.5
hypoproteinemia 5.1
arthralgia 4.0
cerebellar ataxia 3.4
lethargy 2.7
hemoptysis 2.6
regurgitation 2.2
dizziness 2.0
respiratory distress 2.0
splenomegaly 1.9
constipation 1.9
angina 1.8
Ill 1.8
erythema 1.5
dyspnea 1.4
tremor 1.0
overweight 0.5
seizures 0.5
abdominal pain 0.3
diarrhea -0.6
pain -1.8
Drug
Kaolin 9.6
GNA 7.1
Phosphatidylserine 6.8
Galactose 6.8
Eculizumab 6.8
Serum albumin 4.9
IL-1ra 4.8
Bayer 4.6
DM1 4.6
Docetaxel 4.4
uPA 4.2
CaCl2 4.2
CaCl2 4.2
CaCl2 4.1
Asn 4.0
Silica 4.0
Albumin 4.0
Fluorescein 3.8
ADM 3.6
Fluorescein 3.3
ROC 3.3
lysine 2.7
THF 2.2
nitroglycerin 2.1
Nephron 1.7
IFN-gamma 1.4
IL-2 0.4
CSF 0.3
Dermatol -1.8
Enzyme
GP-I 10.9
pregnancy-associated plasma protein-A 7.5
APC 7.0
proteinase-3 6.8
thromboplastin 6.7
lysyl endopeptidase 6.3
Hageman factor 6.2
factor C 5.9
ceruloplasmin 5.9
polo-like kinase 1 5.6
lipoprotein lipase 5.2
methylenetetrahydrofolate reductase 5.2
methylenetetrahydrofolate reductase 5.2
proprotein convertase 5.1
thrombin 5.1
lecithin:cholesterol acyltransferase 5.0
Thy1 5.0
plasmin 4.9
peroxiredoxin 4.8
sialyltransferase 4.6
apyrase 4.6
sialyltransferase 4.6
sialyltransferase 4.6
thyroid peroxidase 4.6
paraoxonase 4.5
MEKK1 4.4
paraoxonase 4.2
chaperonin 4.1
tissue plasminogen activator 4.1
kallikrein 3.7
glyceraldehyde-3-phosphate dehydrogenase 3.1
subtilisin 3.1
glyceraldehyde-3-phosphate dehydrogenase 3.1
glyceraldehyde-3-phosphate dehydrogenase 3.0
phospholipase A2 3.0
urokinase-type plasminogen activator 2.8
glyceraldehyde-3-phosphate dehydrogenase 2.8
caspase-1 2.6
cholinesterase 2.6
glyceraldehyde-3-phosphate dehydrogenase 2.5
papain 2.5
ribonuclease 2.5
ribonuclease 2.5
neuraminidase 2.4
carbonic anhydrase 2.4
cdc2 2.2
elastase 2.1
transcriptase 2.0
proteasome 2.0
NADPH oxidase 1.9
trypsin 1.9
peroxidase 1.8
chymotrypsin 1.8
NADPH oxidase 1.8
RNase 1.2
calcineurin 1.2
RNase 1.1
phospholipase C 1.0
endonuclease 1.0
luciferase 1.0
adenylate cyclase 1.0
alkaline phosphatase 0.7
alanine aminotransferase 0.5
acetylcholinesterase 0.4
RNA polymerase 0.1
renin 0.1
ERK -0.3
mitogen-activated protein kinase -0.3
ATPase -0.8
Compound
PAPS 8.3
APS 8.0
Factor X 7.3
Pantothenate 7.2
nonanoic acid 7.1
nonanoic acid 7.1
nonanoic acid 7.1
nonanoic acid 7.0
Factor H 7.0
APO 6.8
Phosphatidylserine 6.8
Galactose 6.7
MCE 6.6
nonanoic acid 6.4
Hydroxychloroquine 6.3
H-3 6.2
Valine 6.2
N-hydroxysuccinimide ester 6.1
Sialic acid 6.1
Fenofibrate 6.0
GGG 5.9
Plasmin 5.6
DPC 5.6
DPC 5.6
Warfarin 5.4
Nodular 5.4
PCI 5.3
phthalaldehyde 5.3
POPC 5.2
CHAPS 5.0
Neu5Ac 4.9
Pro-Gly 4.8
Docetaxel 4.8
GAL 4.6
GalNAc 4.5
Biotin 4.5
GM2 4.5
ubiquinol 4.5
LPC 4.4
1-propanol 4.3
GlcNAc 4.3
Tween 20 4.3
COS 4.2
Thrombin 4.1
ANA 4.1
ANA 4.1
CaCl2 4.1
GM3 4.1
Heparin 4.1
Fibrin 4.1
HgCl2 4.1
homocysteine 4.0
coenzyme Q10 4.0
Leucine 4.0
GPT 4.0
Nitrite 4.0
PNA 4.0
TOF 3.9
THP 3.9
THP 3.8
PAP 3.8
PPD 3.7
Nitrite 3.7
AAA 3.7
PPD 3.6
Estrogen 3.6
PAP 3.6
PAP 3.6
trifluoroacetic acid 3.5
trifluoroacetic acid 3.5
trifluoroacetic acid 3.5
trifluoroacetic acid 3.5
PAP 3.5
trifluoroacetic acid 3.5
THE 3.2
serine 3.1
thiourea 3.0
MgCl2 3.0
valine 3.0
AMPA 3.0
Estrogen 2.9
lysine 2.8
tryptophan 2.7
tryptophan 2.7
Retinal 2.7
tryptophan 2.7
asparagine 2.7
GM1 2.6
propionic acid 2.6
propionic acid 2.6
leucine 2.5
Gly 2.5
tryptophan 2.5
Ile 2.5
prostaglandin E1 2.4
DEAE 2.3
threonine 2.1
urea 2.1
retinol 1.9
isoleucine 1.9
isoleucine 1.9
proline 1.8
arginine 1.8
SDS 1.8
salicylic acid 1.8
Asp 1.7
MDA 1.7
cysteine 1.6
Phe 1.6
prostacyclin 1.5
PEG 1.4
ADP 1.4
bromide 1.4
Clin 1.3
Triton X-100 1.3
H2O2 1.3
ASA 1.3
NH2 1.3
calcium 1.3
formaldehyde 1.3
sulfate 1.2
glutamic acid 1.2
acrylamide 1.2
Optimal 1.1
alanine 1.1
galactose 1.0
ADP 1.0
ADP 1.0
PEG 1.0
His 1.0
formaldehyde 0.9
AMP 0.9
phosphorus 0.7
aldosterone 0.6
iodine 0.6
glutamine 0.5
HCl 0.5
vitamin D 0.4
Mg2+ 0.4
DNA 0.4
carbonate 0.4
TNF 0.3
ammonium 0.3
tyrosine 0.2
acetic acid 0.1
sodium -0.1
silicon -0.2
ATP -0.2
Dec -0.2
zinc -0.2
copper -0.3
nitric oxide -0.4
oxygen -0.5
salt -0.6
cAMP -0.6
methionine -0.6
methanol -0.7
hydrogen -0.8
iron -0.9
glutamate -0.9
glucose -1.4
Cardiol -1.6
acetate -1.6
ethanol -1.9
water -2.2
phosphate -2.2