Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UNIPROT:P02749 (beta2-glycoprotein I)
 836 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

DNA-binding proteins were isolated from Yoshida ascites tumor fluid by chromatography on DNA-cellulose. This fraction represents 1-2% of the total ascites protein. Most of the DNA-binding proteins will bind to phosphocellulose as well. The proteins migrate by agarose gel electrophoresis at pH 8.6 as alpha and beta globulins. Quantitative immunoelectrophoresis revealed the presence of 12-18 proteins. SDS-polyacrylamide electrophoresis indicated molecular weights ranging from 3-10(4) to 10(6). Seven of the proteins were identified by specific immunoprecipitation as beta1-Eglobulin, beta2-glycoprotein I, fibrinogen split product E (fibrinogen E), coagulation factor XIII (factor XIII), alpha2-macroglobulin, IgG and IgM. Alpha1-antichymotrypsin might also be represented. In nuclear extracts of the tumor cells only factor XIII was present. With the exception of fibrinogen E and P5 all recognized DNA-binding proteins are present in normal rat plasma. With increasing tumor age the concentration of fibrinogen E, factor XIII, P5 and IgM increased both in ascites fluid and in plasma, while the concentration of other DNA-binding-proteins decreased or remained constant. Evidence is presented that the DNA- and phosphocellulose binding ascites protein fraction inhibit tumor cell growth. No inhibition was induced by corresponding protein fractions isolated from normal rat plasma.
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PMID:DNA-binding proteins in Yoshida ascites tumor fluid. 95 99

Analyses of mucoproteins, orcin-positive protein sugar, sialic acid of the alpha2-macroglobulin, alpha1-glycoprotein, alpha1-antitrypsin, alpha2-HS-glycoprotein and beta2-glycoprotein I were carried out in 302 diabetics. In creases of concentration could be proved for alpha2-macroglobulin, alpha2-HS-glycoprotein, orcin-positive protein sugar and sialic acid. In diabetics with retinopathies the alpha2-macroglobulin concentration is significantly increased compared with diabetics without retinopathies.
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PMID:[Glycoproteins in diabetes mellitus]. 108 92

In 48 men occupationally exposed to CS2 the following glycoproteins were estimated in blood serum, using radial immunodiffusion on M-Partigen plates: alpha1-acid glycoprotein, alpha1-antitrypsin, alpha2-HS-glycoprotein, alpha2-macroglobulin, Gc glycoprotein, hemopexin, haptoglobin, ceruluplasmin and beta2-glycoprotein I. The studies indicated a highly statistically significant increase of: alpha1-acid--glycoprotein and Gc glycoprotein, and decrease of: alpha1-antitrypsins, alpha2-HS--glycoprotein and beta2-glycoprotein. The level of the remaining glycoproteins was normal.
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PMID:[Blood serum glycoproteins in men exposed to carbon disulfide]. 616 75