Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UNIPROT:P02749 (
beta2-glycoprotein I
)
836
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
beta 2-Glycoprotein I (
apolipoprotein H
), a constituent of normal human plasma, has been shown to inhibit the generation of amidolytic activity in plasma that has been exposed to negatively charged agents. Studies with purified
Hageman factor
(factor XII) demonstrate that this inhibitory property is directed against the activation of
Hageman factor
. In this study
beta 2-glycoprotein I
inhibited the kaolin-induced generation of clot-promoting properties in solutions of
Hageman factor
. This effect was localized to an interaction between
beta 2-glycoprotein I
and kaolin. In contrast, once
Hageman factor
was activated by kaolin, its clot-promoting properties were not inhibited by
beta 2-glycoprotein I
. Further, beta 2-glycoprotein inhibited the generation of amidolytic activity against H-D-prolyl-L-phenylalanyl-L-arginine p-nitroanilide dihydrochloride in mixtures of
Hageman factor
and ellagic acid. The specificity of the action of
beta 2-glycoprotein I
was confirmed by its neutralization by immunoglobulin fractions of antiserums directed against this protein.
...
PMID:Inhibition of the activation of Hageman factor (factor XII) by beta 2-glycoprotein I. 336 Dec 30
