Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UNIPROT:P02749 (
beta2-glycoprotein I
)
836
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The temperature-induced budding of
POPC
-cardiolipin-cholesterol,
POPC
-POPS-cholesterol and
POPC
-POPG-cholesterol giant lipid vesicles in the presence of
beta 2-glycoprotein I
(
beta 2-GPI
) in the outer solution was studied experimentally and theoretically. The observed budding transition of vesicles was continuous which can be explained by taking into account the orientational ordering and direct interactions between oriented lipids. The attachment of positively charged
beta 2-GPI
to the negatively charged outer surface of
POPC
-cardiolipin-cholesterol,
POPC
-POPS-cholesterol and
POPC
-POPG-cholesterol giant vesicles caused coalescence of the spheroidal membrane bud with the parent vesicle before the bud could detach from the parent vesicle, i.e. vesiculate. Theoretically, the protein-mediated attraction between the membrane of a bud and the parent membrane was described as an interaction between two electric double layers. It was shown that the specific spatial distribution of charge within
beta 2-GPI
molecules attached to the negatively charged membrane surface may explain the observed attraction between like-charged membrane surfaces.
...
PMID:Attachment of beta 2-glycoprotein I to negatively charged liposomes may prevent the release of daughter vesicles from the parent membrane. 1818 52
