Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UNIPROT:P02749 (
beta2-glycoprotein I
)
836
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Washed human platelets were preincubated with 0-300 micrograms/ml human
beta 2-glycoprotein I
and the effect of this on the
adenylate cyclase
activity (EC.4.6.1.1.) was studied. Adenylate cyclase activity could be increased 2-3 fold. The same degree of activation was seen when low concentrations of prostaglandin E1 (1 microM) had been present concomitant with
beta 2-glycoprotein I
during preincubation. The dose-response curves of the
adenylate cyclase
activity measured as a function of the
beta 2-glycoprotein I
concentration were S-shaped in the absence of prostaglandin E1 and hyperbolic in its presence. The results suggest a biological function of
beta 2-glycoprotein I
as a compound conserving and activating the membrane-bound
adenylate cyclase
.
...
PMID:Effect of beta 2-glycoprotein I on the activity of adenylate cyclase in platelet membranes. 668 48
