Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UNIPROT:P01889 (ankylosing spondylitis)
5,717 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
ankylosing spondylitis 5717
HLA-B27 771
B27 540
HLA 471
TNF 371
Sep 337
tumor necrosis factor 275
C-reactive protein 217
cytokine 163
IgA 145
IL-17 117
TNF-alpha 103
human leukocyte antigen 102
CRP 98
rheumatoid factor 96
ESR 95
MRI 90
gut 84
Mol 82
major histocompatibility complex 74
HLA-B 64
IL-23 61
Tumor necrosis factor 56
collagen 51
IL-6 48
MHC 48
endoplasmic reticulum 47
tumor necrosis factor alpha 46
HLA-B*27 43
ERAP1 41
CD4 37
alkaline phosphatase 35
CD8 34
heavy chain 34
B*2706 34
Mal 34
HLA class I 33
She 32
histocompatibility antigen 30
IL-1 30
asymmetrical 29
IL23R 27
lymphoid 27
insulin 25
HLA-A 25
interleukin-17 25
HLA B 24
proteoglycan 24
Hip 24
MHC class I 23
TNF receptor 23
interferon 21
fused 20
cage 19
HLA-DR4 19
Endoplasmic reticulum aminopeptidase 1 18
IL-10 17
DR4 17
IFN 17
Human leukocyte antigen 17
hemoglobin 16
aminopeptidase 16
interleukin-6 16
IL-4 16
lipopolysaccharide 15
type II collagen 15
human leucocyte antigen 15
ANA 14
parathyroid hormone 14
IBD 13
B13 13
osteocalcin 13
COX-2 13
major histocompatibility complex class I 12
ERAP2 12
osteogenic 12
renal amyloidosis 12
Pol 12
TCR 12
IL-22 12
more...
Disease
ankylosing spondylitis 5709
rheumatoid arthritis 1627
arthritis 1091
psoriatic arthritis 889
HLA-B27 771
psoriasis 474
systemic lupus erythematosus 396
osteoarthritis 353
sacroiliitis 318
Crohn's disease 316
inflammatory bowel disease 311
Reiter's syndrome 282
spondyloarthropathy 247
uveitis 243
spondylitis 189
anterior uveitis 172
ulcerative colitis 168
enthesitis 162
arthropathy 158
arthrodesis 154
tuberculosis 141
juvenile rheumatoid arthritis 130
osteoporosis 125
Klebsiella 110
gout 106
hyperostosis 102
cancer 101
vasculitis 99
PSS 86
autoimmune disease 85
multiple sclerosis 84
synovitis 82
sarcoidosis 74
rheumatism 74
lupus 70
Spondyloarthritis 68
tumor 67
polyarthritis 67
fibromyalgia 66
Best 66
lupus 64
depression 62
diabetes 62
amyloidosis 61
cauda equina syndrome 60
aortic regurgitation 56
plaque 56
Yersinia 56
enthesopathy 52
cardiovascular disease 49
dermatomyositis 48
scleroderma 47
hypertension 44
atherosclerosis 43
polymyositis 43
iritis 40
dactylitis 40
osteitis 37
Behcet's disease 37
infectious diseases 33
chronic pain 31
asthma 30
mimicry 30
familial Mediterranean fever 30
lymphoma 29
colitis 29
leukemia 29
polymyalgia rheumatica 28
IgA nephropathy 27
mixed connective tissue disease 27
proteinuria 27
celiac disease 26
rash 26
Diffuse idiopathic skeletal hyperostosis 26
erythema nodosum 25
Still's disease 25
pyoderma gangrenosum 24
SLE 24
Chlamydia 24
systemic disease 24
more...
Symptom
pain 578
back pain 204
low back pain 117
fatigue 73
anesthesia 50
arthralgia 49
diarrhea 38
neck pain 36
weakness 35
headache 26
abdominal pain 21
discomfort 19
discomfort 19
dyspnea 18
chronic back pain 17
hip pain 17
cough 15
heel pain 15
sciatica 12
nausea 11
analgesia 11
swollen joints 10
chest pain 9
acute pain 9
distraction 9
shoulder pain 8
knee pain 8
numbness 8
dizziness 8
hemoptysis 8
paraparesis 7
paresthesia 7
regurgitation 7
erythema 6
dry eye 5
seizures 5
bone pain 5
paresis 5
vertigo 4
myalgia 4
vomiting 4
collapse 4
polymyalgia 4
anorexia 4
tinnitus 4
asthenia 4
leg pain 4
insomnia 4
Stiffness 4
clubbing 4
night sweats 3
thinning 3
spasm 3
shortness of breath 3
generalized pain 3
dystonia 3
respiratory distress 3
Poor sleep 3
groin pain 3
livedo 2
cachexia 2
cancer pain 2
functional recovery 2
thigh pain 2
dark urine 2
Hyperextension 2
arm pain 2
overweight 2
spasticity 2
eye pain 2
hemiplegia 2
Musculoskeletal symptoms 2
dysesthesia 2
chronic constipation 2
angina 2
Ill 2
syncope 2
dysarthria 2
dental pain 2
intestinal bleeding 2
more...
Drug
Infliximab 79
Infliximab 79
Dermatol 57
Adalimumab 51
p75 33
Golimumab 25
Monit 15
CSF 13
Sulphasalazine 12
IFN-gamma 10
Tenoxicam 9
CTX 7
Cardiovasc 7
CTX 7
FLP 7
IL-2 7
CTX 7
Indomethacin 7
lysine 6
ABC 6
ROC 6
Etodolac 6
Certolizumab pegol 6
Aceclofenac 5
Diclofenac sodium 5
Rituximab 5
Asthma 4
Nephron 4
PTH 4
IL-1ra 4
Nephron 4
Tuberculin 4
MAP 4
Abatacept 3
Oxaprozin 3
Anakinra 3
Posture 2
Adefovir dipivoxil 2
CAM 2
EPI 2
THA 2
RFP 2
Arthrex 2
Feprazone 2
Nabumetone 2
Asn 2
SPP 2
Auranofin 2
Dial 2
Fenoprofen 2
Alclofenac 2
Leaf 2
Pirprofen 2
ENT 1
Rifaximin 1
Mobic 1
Campath 1
Tiaprofenic acid 1
Lornoxicam 1
Methylprednisolone 1
Arava 1
Rosuvastatin 1
Salmon calcitonin 1
G-CSF 1
Isoxicam 1
SBT 1
CED 1
AMC 1
CaCl2 1
BCG vaccine 1
EE2 1
Gel 1
NAG 1
Fenbufen 1
Check 1
IFN-beta 1
CaCl2 1
NADH 1
ascorbate 1
Triad 1
more...
Enzyme
alkaline phosphatase 35
nitrogenase 13
peroxidase 11
ERK 9
proteasome 9
catalase 7
trypsin 7
superoxide dismutase 6
MDP 6
gamma-glutamyl transpeptidase 5
phosphodiesterase 5
focal adhesion kinase 5
mitogen-activated protein kinase 5
aldehyde dehydrogenase 4
collagenase 4
MMP-3 4
ceruloplasmin 4
alanine aminotransferase 4
creatine kinase 4
caspase-1 4
elastase 3
luciferase 3
MAP 3
type III procollagen 3
protein kinase 3
glutathione peroxidase 3
aspartate aminotransferase 3
glutathione S-transferase 2
PDE 2
hyaluronidase 2
proteinase-3 2
pullulanase 2
pepsin 2
neuraminidase 2
carbonic anhydrase 2
MMP 2
uricase 2
chymotrypsin 2
oxytocinase 2
SPC 2
papain 2
ACE 2
thyroid peroxidase 2
thrombin 2
MIP 2
chondroitinase 2
chondroitinase 2
AST 2
proteinase K 1
tissue plasminogen activator 1
plasmin 1
urokinase-type plasminogen activator 1
deoxyribonuclease 1
chymopapain 1
endonuclease 1
deaminase 1
CD10 1
acid phosphatase 1
cathepsin K 1
homogentisate 1,2-dioxygenase 1
AMPK 1
peptidylarginine deiminase 1
ATPase 1
CDH 1
11beta-hydroxysteroid dehydrogenase 1
methionine synthase reductase 1
aldolase 1
urease 1
lysozyme 1
cathepsin G 1
DNA polymerase 1
dipeptidyl peptidase IV 1
caspase-3 1
GSK 1
ATP synthase 1
AMPK 1
prostaglandin synthetase 1
transglutaminase 1
AMP-activated protein kinase 1
calcineurin 1
more...
Compound
Clin 1042
Dec 425
TNF 371
DNA 84
Etanercept 71
calcium 54
His 41
Sulfasalazine 29
sodium 29
arginine 28
vitamin D 24
glucose 22
oxygen 21
HAQ 20
Cardiol 19
Methotrexate 17
leucine 17
BAS 17
phosphate 15
ANA 14
ANA 14
tyrosine 13
water 13
cysteine 13
PEG 13
Asp 13
lysine 11
phosphorus 10
creatinine 9
homocysteine 9
acetate 9
ANCA 8
salt 8
zinc 8
iron 8
Etoricoxib 8
propionic acid 8
B17 8
propionic acid 8
T11 8
sulfate 7
Phe 7
CTX 7
BMD 7
Diclofenac 7
Guo 7
Indomethacin 7
MTX 7
copper 7
Guo 7
Hearts 6
nitric oxide 6
TAP 6
CCP 6
alanine 6
nitrogen 6
Abbott 5
Tumor Necrosis Factor 5
CO2 5
phenylacetic acid 5
phenylacetic acid 5
Naproxen 5
ethanol 5
phenylacetic acid 5
T10 5
phenylacetic acid 5
hyaluronic acid 4
aspartic acid 4
Celecoxib 4
Insulin 4
Congo red 4
A 42 4
Levamisole 4
Vitamin D 4
aspartic acid 4
ACTH 4
Meloxicam 4
DBA 4
aspartic acid 4
acetic acid 4
more...