Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UNIPROT:P01889 (ankylosing spondylitis)
 5,717 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
ankylosing spondylitis 5717
HLA-B27 771
B27 540
HLA 471
TNF 371
Sep 337
tumor necrosis factor 275
C-reactive protein 217
cytokine 163
IgA 145
IL-17 117
TNF-alpha 103
human leukocyte antigen 102
CRP 98
rheumatoid factor 96
ESR 95
MRI 90
gut 84
Mol 82
major histocompatibility complex 74
HLA-B 64
IL-23 61
Tumor necrosis factor 56
collagen 51
MHC 48
IL-6 48
endoplasmic reticulum 47
tumor necrosis factor alpha 46
HLA-B*27 43
ERAP1 41
CD4 37
alkaline phosphatase 35
Mal 34
CD8 34
heavy chain 34
B*2706 34
HLA class I 33
She 32
histocompatibility antigen 30
IL-1 30
asymmetrical 29
IL23R 27
lymphoid 27
insulin 25
HLA-A 25
interleukin-17 25
HLA B 24
Hip 24
proteoglycan 24
MHC class I 23
TNF receptor 23
interferon 21
fused 20
HLA-DR4 19
cage 19
Endoplasmic reticulum aminopeptidase 1 18
IL-10 17
Human leukocyte antigen 17
IFN 17
DR4 17
hemoglobin 16
IL-4 16
interleukin-6 16
aminopeptidase 16
type II collagen 15
lipopolysaccharide 15
human leucocyte antigen 15
parathyroid hormone 14
ANA 14
COX-2 13
B13 13
IBD 13
osteocalcin 13
Hop 12
IL-22 12
Pol 12
TCR 12
renal amyloidosis 12
major histocompatibility complex class I 12
osteogenic 12
ERAP2 12
interferon-gamma 11
cyclooxygenase-2 11
TLR4 11
p75 11
osteoprotegerin 11
SOD 11
Cytokine 11
HLA-A2 11
IL-23R 11
HLA-C 11
HLA-DR 11
CD25 11
Dickkopf-1 10
RANKL 10
Men 10
CSF 10
fibrinogen 10
IFN-gamma 10
KIR3DS1 9
sclerostin 9
STAT3 9
T12 9
ACR 9
bone morphogenetic protein 8
T11 8
IgA1 8
albumin 8
T cell receptor 8
LPS 8
tapasin 8
type I collagen 8
DR3 8
B17 8
prolactin 8
kit 8
peroxidase 8
aggrecan 8
JAMA 8
DKK1 8
tumor necrosis factor receptor 8
IL-8 8
proteasome 8
IL-17RA 7
adhesion molecule 7
serum albumin 7
growth hormone 7
CTX 7
vimentin 7
DR1 7
A27 7
BMD 7
dimeric 7
B18 7
MICA 7
leptin 7
IL-2 7
HLA-B51 7
alpha 1-antitrypsin 7
NOD2 7
adiponectin 7
IL-17F 7
Nei 7
CD14 7
ICD 7
B60 7
vascular endothelial growth factor 7
ARA 7
IL17 7
Tumor necrosis factor alpha 7
chronic renal failure 7
LMP2 7
MTX 7
chemokine 6
CCP 6
lymphotoxin 6
ABC 6
superoxide dismutase 6
PHA 6
hemochromatosis 6
more...
Disease
ankylosing spondylitis 5709
rheumatoid arthritis 1627
arthritis 1091
psoriatic arthritis 889
HLA-B27 771
psoriasis 474
systemic lupus erythematosus 396
osteoarthritis 353
sacroiliitis 318
Crohn's disease 316
inflammatory bowel disease 311
Reiter's syndrome 282
spondyloarthropathy 247
uveitis 243
spondylitis 189
anterior uveitis 172
ulcerative colitis 168
enthesitis 162
arthropathy 158
arthrodesis 154
tuberculosis 141
juvenile rheumatoid arthritis 130
osteoporosis 125
Klebsiella 110
gout 106
hyperostosis 102
cancer 101
vasculitis 99
PSS 86
autoimmune disease 85
multiple sclerosis 84
synovitis 82
rheumatism 74
sarcoidosis 74
lupus 70
Spondyloarthritis 68
polyarthritis 67
tumor 67
fibromyalgia 66
Best 66
lupus 64
diabetes 62
depression 62
amyloidosis 61
cauda equina syndrome 60
aortic regurgitation 56
Yersinia 56
plaque 56
enthesopathy 52
cardiovascular disease 49
dermatomyositis 48
scleroderma 47
hypertension 44
polymyositis 43
atherosclerosis 43
iritis 40
dactylitis 40
osteitis 37
Behcet's disease 37
infectious diseases 33
chronic pain 31
familial Mediterranean fever 30
asthma 30
mimicry 30
colitis 29
lymphoma 29
leukemia 29
polymyalgia rheumatica 28
mixed connective tissue disease 27
IgA nephropathy 27
proteinuria 27
Diffuse idiopathic skeletal hyperostosis 26
rash 26
celiac disease 26
erythema nodosum 25
Still's disease 25
SLE 24
pyoderma gangrenosum 24
Chlamydia 24
systemic disease 24
aortitis 23
Acute anterior uveitis 23
iridocyclitis 23
Sjogren's syndrome 23
spondylosis 23
obesity 22
skin disease 22
urethritis 22
Mycobacterium 22
Wegener's granulomatosis 21
rheumatic fever 21
type 1 diabetes 21
multiple myeloma 20
anemia 20
PDB 19
acne 19
nephrotic syndrome 19
sacroilitis 19
Infection 19
osteomalacia 19
inflammatory joint disease 19
bursitis 19
heart failure 18
AA amyloidosis 18
pulmonary fibrosis 18
Tumour necrosis 18
glomerulonephritis 18
myelopathy 17
Takayasu 17
irritable bowel syndrome 17
renal failure 17
Proteus 17
renal disease 17
primary sclerosing cholangitis 16
giant cell arteritis 16
congestive heart failure 16
heart block 16
Shigella 16
Reactive arthritis 16
enteropathy 16
spinal cord compression 15
polyarteritis nodosa 15
dysplasia 15
Whipple's disease 15
conjunctivitis 15
stroke 15
HIV 15
metabolic syndrome 15
osteomyelitis 15
sepsis 15
Anterior 14
West 14
scoliosis 14
lung disease 14
Graves' disease 14
mitral regurgitation 14
septic arthritis 14
dysphagia 14
spinal stenosis 13
pneumonia 13
hepatitis B 13
chondrocalcinosis 13
vitiligo 13
sleep disturbances 13
paraplegia 13
coxarthrosis 13
chronic disease 13
myocardial infarction 13
myositis 13
connective tissue disease 13
pseudogout 13
hepatitis 12
Poland 12
arachnoiditis 12
Infections 12
breast cancer 12
myasthenia gravis 12
cataract 12
metastases 12
tendinitis 12
more...
Symptom
pain 578
back pain 204
low back pain 117
fatigue 73
anesthesia 50
arthralgia 49
diarrhea 38
neck pain 36
weakness 35
headache 26
abdominal pain 21
discomfort 19
discomfort 19
dyspnea 18
chronic back pain 17
hip pain 17
cough 15
heel pain 15
sciatica 12
analgesia 11
nausea 11
swollen joints 10
distraction 9
chest pain 9
acute pain 9
knee pain 8
hemoptysis 8
dizziness 8
numbness 8
shoulder pain 8
regurgitation 7
paraparesis 7
paresthesia 7
erythema 6
paresis 5
seizures 5
bone pain 5
dry eye 5
leg pain 4
Stiffness 4
clubbing 4
collapse 4
polymyalgia 4
anorexia 4
tinnitus 4
vertigo 4
vomiting 4
asthenia 4
insomnia 4
myalgia 4
thinning 3
spasm 3
groin pain 3
night sweats 3
shortness of breath 3
generalized pain 3
Poor sleep 3
dystonia 3
respiratory distress 3
cancer pain 2
overweight 2
functional recovery 2
livedo 2
eye pain 2
cachexia 2
dark urine 2
arm pain 2
dysesthesia 2
spasticity 2
chronic constipation 2
angina 2
sleepiness 2
syncope 2
intestinal bleeding 2
dysarthria 2
Ill 2
dental pain 2
Musculoskeletal symptoms 2
Hyperextension 2
hemiplegia 2
thigh pain 2
acute low back pain 2
neck stiffness 1
hoarseness 1
hyperesthesia 1
hypoproteinemia 1
urinary frequency 1
lethargy 1
Livedoid 1
painful swallowing 1
vaginal discomfort 1
cerebellar ataxia 1
renal colic 1
muscle cramps 1
thoracic back pain 1
muscle stiffness 1
limb pain 1
cardiovascular impairment 1
pedal edema 1
pleuritic chest pain 1
pain in the buttock 1
rib pain 1
apathy 1
chorea 1
splenomegaly 1
photophobia 1
Ochronotic pigmentation 1
loss of taste 1
Gastrointestinal symptoms 1
stomach pain 1
exertional dyspnea 1
constipation 1
chronic cough 1
nausea and vomiting 1
ankle pain 1
Sacroiliac joint laxity 1
body pain 1
postpartum pain 1
rhinorrhea 1
motor symptom 1
anosmia 1
despair 1
productive cough 1
dysuria 1
right lower quadrant pain 1
aphonia 1
Overlying 1
Cardiovascular symptoms 1
mental fatigue 1
Physical findings 1
fever of unknown origin 1
torticollis 1
disturbed balance 1
Halo 1
loin pain 1
Neuropathic pain 1
Severe pain 1
tachypnea 1
epigastric pain 1
chills 1
non-productive cough 1
lumbar instability 1
rales 1
stigma 1
urethral discharge 1
neuralgia 1
sore throat 1
Intermittent fever 1
Radicular pain 1
ataxia 1
Drug
Infliximab 79
Infliximab 79
Dermatol 57
Adalimumab 51
p75 33
Golimumab 25
Monit 15
CSF 13
Sulphasalazine 12
IFN-gamma 10
Tenoxicam 9
Indomethacin 7
FLP 7
IL-2 7
CTX 7
CTX 7
CTX 7
Cardiovasc 7
ROC 6
Etodolac 6
lysine 6
Certolizumab pegol 6
ABC 6
Aceclofenac 5
Diclofenac sodium 5
Rituximab 5
Asthma 4
IL-1ra 4
PTH 4
Nephron 4
Nephron 4
Tuberculin 4
MAP 4
Abatacept 3
Oxaprozin 3
Anakinra 3
CAM 2
EPI 2
THA 2
Arthrex 2
Posture 2
RFP 2
Adefovir dipivoxil 2
Asn 2
Auranofin 2
Nabumetone 2
Feprazone 2
SPP 2
Fenoprofen 2
Alclofenac 2
Dial 2
Leaf 2
Pirprofen 2
ENT 1
Rifaximin 1
Mobic 1
Campath 1
Tiaprofenic acid 1
Lornoxicam 1
Methylprednisolone 1
Arava 1
Rosuvastatin 1
Salmon calcitonin 1
G-CSF 1
Isoxicam 1
SBT 1
CED 1
Streptokinase 1
CaCl2 1
Vitamin B12 1
BCG vaccine 1
EE2 1
Gel 1
NAG 1
Fenbufen 1
CaCl2 1
AMC 1
Isoniazid 1
ascorbate 1
Profenid 1
IFN-beta 1
CaCl2 1
Triad 1
vitamin E 1
Retinoic acid 1
Check 1
Fluorescein 1
NADH 1
Omeprazole 1
Denosumab 1
ROS 1
Aristocort 1
Pronase 1
Novantrone 1
Prednisone 1
Meclomen 1
Celebrex 1
Heme 1
Campath 1
Camp 1
Budesonide 1
Meclomen 1
nitroglycerin 1
Anafranil 1
Diurnal 1
Feldene 1
Moxifloxacin 1
Iguratimod 1
CIA 1
Fluorescein 1
Enzyme
alkaline phosphatase 35
nitrogenase 13
peroxidase 11
proteasome 9
ERK 9
trypsin 7
catalase 7
MDP 6
superoxide dismutase 6
focal adhesion kinase 5
phosphodiesterase 5
gamma-glutamyl transpeptidase 5
mitogen-activated protein kinase 5
aldehyde dehydrogenase 4
alanine aminotransferase 4
MMP-3 4
ceruloplasmin 4
creatine kinase 4
collagenase 4
caspase-1 4
MAP 3
luciferase 3
elastase 3
protein kinase 3
glutathione peroxidase 3
aspartate aminotransferase 3
type III procollagen 3
PDE 2
hyaluronidase 2
proteinase-3 2
chondroitinase 2
SPC 2
MMP 2
thyroid peroxidase 2
MIP 2
chondroitinase 2
pepsin 2
neuraminidase 2
uricase 2
carbonic anhydrase 2
papain 2
glutathione S-transferase 2
pullulanase 2
chymotrypsin 2
ACE 2
thrombin 2
oxytocinase 2
AST 2
proteinase K 1
tissue plasminogen activator 1
plasmin 1
urokinase-type plasminogen activator 1
deoxyribonuclease 1
chymopapain 1
endonuclease 1
deaminase 1
CD10 1
acid phosphatase 1
cathepsin K 1
homogentisate 1,2-dioxygenase 1
AMPK 1
peptidylarginine deiminase 1
ATPase 1
CDH 1
dimethylarginine dimethylaminohydrolase 1
Lod 1
SPS 1
aldolase 1
urease 1
peroxiredoxin 1
microsomal epoxide hydrolase 1
leucine aminopeptidase 1
Thy1 1
dipeptidyl peptidase IV 1
caspase-3 1
alanine aminopeptidase 1
GSK 1
adenosine deaminase 1
methionine synthase reductase 1
11beta-hydroxysteroid dehydrogenase 1
AMPK 1
paraoxonase 1
cathepsin G 1
lysozyme 1
aminopeptidase I 1
prostaglandin synthetase 1
AMP-activated protein kinase 1
urease 1
DNA polymerase 1
NOS 1
ATP synthase 1
phosphoglucose isomerase 1
neutrophil elastase 1
transcriptase 1
lactate dehydrogenase 1
transglutaminase 1
reverse transcriptase 1
deoxyribonuclease 1
p100 1
adenosine deaminase 1
lipoxygenase 1
cathepsin B 1
calcineurin 1
chymopapain 1
demethylase 1
RNA polymerase 1
factor D 1
prolidase 1
beta-galactosidase 1
21-hydroxylase 1
galactosylhydroxylysyl glucosyltransferase 1
prolyl hydroxylase 1
kinesin 1
MDR 1
DNase 1
TMT 1
paraoxonase 1
Compound
Clin 1042
Dec 425
TNF 371
DNA 84
Etanercept 71
calcium 54
His 41
sodium 29
Sulfasalazine 29
arginine 28
vitamin D 24
glucose 22
oxygen 21
HAQ 20
Cardiol 19
leucine 17
Methotrexate 17
BAS 17
phosphate 15
ANA 14
ANA 14
tyrosine 13
water 13
PEG 13
cysteine 13
Asp 13
lysine 11
phosphorus 10
homocysteine 9
acetate 9
creatinine 9
zinc 8
ANCA 8
Etoricoxib 8
iron 8
propionic acid 8
propionic acid 8
B17 8
salt 8
T11 8
Phe 7
sulfate 7
Guo 7
Diclofenac 7
copper 7
Indomethacin 7
CTX 7
Guo 7
MTX 7
BMD 7
Hearts 6
TAP 6
nitric oxide 6
alanine 6
nitrogen 6
CCP 6
Tumor Necrosis Factor 5
Naproxen 5
T10 5
Abbott 5
CO2 5
phenylacetic acid 5
phenylacetic acid 5
phenylacetic acid 5
phenylacetic acid 5
ethanol 5
Meloxicam 4
aspartic acid 4
hyaluronic acid 4
Celecoxib 4
DBA 4
aspartic acid 4
Congo red 4
ACTH 4
BCG 4
DBA 4
aspartic acid 4
aspartic acid 4
Optimal 4
Levamisole 4
Thyroid 4
Ile 4
Insulin 4
acetic acid 4
DBA 4
Vitamin D 4
serine 4
A 42 4
MEP 3
Phenylbutazone 3
Neo 3
THP 3
fluorine 3
Oxaprozin 3
EDTA 3
PPD 3
barium 3
A 71 3
PEG 3
hydroxide 3
MEP 3
IBP 3
threonine 3
Pac 3
hydrogen 3
Wellcome 3
BMC 3
INH 3
Benoxaprofen 3
MAP 3
PPD 3
Piroxicam 3
valine 3
THP 3
glutamine 3
6-12 3
APAP 3
EDTA 3
ASA 3
MIC 3
IBP 3
Ibuprofen 3
potassium 2
DTPA 2
TOF 2
CES 2
retinoic acid 2
PMS 2
carbonate 2
GSH 2
Collagen 2
CAT 2
Sulindac 2
Pamidronate 2
strontium 2
TSH 2
Dial 2
ATP 2
titanium 2
PVP 2
isoleucine 2
Meclofenamate 2
CAT 2
Homocysteine 2
cAMP 2
isoleucine 2
Cholesterol 2
ALP 2
chromium 2
cobalt 2
Ketoprofen 2
Nitrite 2
Xenon 2
Gly 2
Mg2+ 2
manganese 2
bromide 2
naphthalene 2
Leflunomide 2
Adenosine 2
more...