Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:P01889 (ankylosing spondylitis)
 5,717 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Quantitative sacro-iliac (SI) joint scanning with methylene diphosphonate labelled with technetium-99 (99TcMDP) was performed in 25 control patients, in 16 patients with definite ankylosing spondylitis, in 23 patients with mechanical low back pain, and in 12 patients with seronegative arthritis. The mean radio-isotope index in the control group was 1.2 +/- 0.15. The highest value was 1.5. Values in excess of 1.5 were seen in patients with clinically active ankylosing spondylitis but not those with inactive disease. Three of the 12 seronegative arthritis patients (without clinical or radiological evidence of sacro-iliitis) had elevated values: all of these were positive for HL-A B27. An important finding was that six of the 23 patients with mechanical or non-specific low back pain had values above 1.5, unassociated with B27. These data emphasize the need for caution in the interpretation of abnormal sacro-iliac scans. Radio-isotope bone scanning can provide a qualitative and quantitative assessment of inflammatory activity in joints with minimal radiation exposure. Various authors have shown its value in providing early evidence of sacro-iliitis (Russell et al., 1975; Namey et al., 1977). In this study, methylene diphosphonate labelled with technetium-99 (99TcMMDP) has been used to produce quantitative sacro-iliac scans in order to evaluate sacro-iliac disease in four groups of patients presenting with or without low back pain.
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PMID:Sacro-iliac joint scanning with technetium-99 diphosphonate. 15 22

Bone scintigraphs obtained with both Technetium-99m polyphosphate and Technetium-99m pyrophosphate have been abnormal at the sacroiliac joints of 44 patients with definite ankylosing spondylitis (AS). Because of the normal registration of the sacroiliac joints on bone scintigraphy, it has been necessary to develop a profile-scan technique to quantify the abnormality that proves to be significantly different from the normal finding. In 17 patients with a strong clinical suspicion of AS but normal radiographs, the sacroiliac joints have frequently been abnormal. This finding is meaningful because there is a common occurence in this group of the histocompatibility antigen HL A-B27, known to be a marker of AS. We also note the frequency of abnormal sacroiliac scinitigrams in 26 patients with rheumatoid arthritis and in a group of other diseases-Crohn's disease, uveitis, psoriasis, ulcerative colitis, and Reiter's disease-all of which share some of the manifestations of AS.
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PMID:The scintigraphic investigation of sacroiliac disease. 19 57

Using a standard microdroplet lymphocyte cytotoxicity test for tissue typing, the distribution of the HLA antigens was determined in 37 female patients; 25 with osteitis condensans ilii (OCI) and 12 with ankylosing spondylitis (AS). Although low back pain was a common feature of OCI, none of these patients exhibited the limitation of spinal involvement, radiological evidence of spondylitis, or progressive clinical course seen in the AS group. Four of the 25 patients with OCI (16 per cent) were B27 positive vs 11 of the 12 patients with AS (92 per cent). These results suggest that OCI is not a variant of AS in women.
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PMID:HLA antigens in osteitis condensans ilii and ankylosing spondylitis. 26 91

Thirty-eight patients with ankylosing spondylitis (AS) and 494 unrelated controls in Sardinia were HLA Typed. HLA B27 was present in 81.8 per cent of AS vs 5.3 per cent of controls (relative risk: 80). Twenty-six apparently healthy B27 positive individuals were studied clinically and radiologically, and six (23.0 per cent) presented signs of definite or suspicious AS. A family study on relatives of seven AS B27-positive and four AS B27-negative patients was also made. The results suggest a dominant heredity of AS susceptibility, and are compatible with a direct involvement of the B27 antigen in the mechanism of AS, but we cannot rule out a closely linked disease-susceptibility gene with incomplete penetrance.
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PMID:HLA B27 and ankylosing spondylitis: a population and family study in Sardinia. 26 92

The distribution of 24 HLA antigens of the A and B loci was investigated in 38 Israeli ankylosing spondylitis (AS) patients of various ethnic origins. This was compared with the distribution in rheumatoid arthritis (RA) and osteoarthritis (OA), as well as in 456 controls representing the Jewish population and 260 controls representing the Arab population. Included in the study were Ashkenazi Jews and non-Ashkenazi Jews, as well as Moslem and Christian Arabs. The frequency of HLA B27 among AS patients (79 per cent) was significantly greater (P less than 10(-10)) than among the controls (three per cent). Ashkenazi Jews showed a higher relative risk than non-Ashkenazi Jews and Arabs. Six of the AS patients were offspring of consanguineous marriages, but this was not higher than expected and therefore no indication for rare recessive genes contributing to the disease could be demonstrated. This study confirms the association between AS and B27, and extends our knowledge to the heterogeneous population of Israel not previously investigated. A significant but weak association of B27 with RA was noted. No correlation of other HLA antigens with RA or OA was observed.
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PMID:HLA B27 and ankylosing spondylitis in the Israeli population. 26 93

On the basis of (a) our epidemiological studies of ankylosing spondylitis (AS) (males 0.4 per cent, females 0.08 per cent), (b) typing of 352 normal persons (frequency of HLA B27 = 12.78 per cent), and (c) typing of 55 AS patients (frequency of HLA B27 = 92.73 per cent), we have calculated the prevalence of AS for the total Hungarian population over 15 years of age. Among males with the B27 anitgen, AS occurs in 2.9 per cent, and in B27 positive females 0.58 per cent. In the population without the B27 antigen, the prevalence of the disease is 0.03 per cent and 0.006 per cent respectively. The quotients of these data show that a person with the B27 antigen has approximately 87 times greater risk of developing AS, than does a person of the same sex without this antigen.
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PMID:Distribution of HLA B27 and ankylosing spondylitis in the Hungarian population. 26 94

Twenty-eight HLA alleles of the A and B loci were determined in 23 American Blacks and 50 Caucasians with primary ankylosing spondylitis (AS). The prevalence of HLA B27 was significantly increased in American Black patients (48 per cent) vs Black controls (two per cent), but was much less than the 94 per cent found in Caucasian patients (controls eight per cent). The lower prevalence of B27 in American Black patients vs Caucasian patients was significant (p less than 0.001), and indicated that susceptibility to AS is not as closely associated with B27 in Blacks as in Caucasians. No other HLA antigen was significantly associated with AS in either racial group. Among B27 positive individuals, the relative risk of developing AS was significantly lower in American Blacks than in Caucasians. These data indicate that for diagnostic purposes, the absence of B27 is less important in ruling out AS in Blacks than in Caucasians.
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PMID:HLA B27 in ankylosing spondylitis: differences in frequency and relative risk in American Blacks and Caucasians. 26 95

Since HLA B27 and ankylosing spondylitis are more common in American Indians than other Americans, the association between radiological sacroiliitis (SI) and HLA B27 was examined among the Pima Indians. SI (grade II to IV) was found in 20 per cent of randomly selected Pima adults. B27 was present in 50 per cent of males, but in only nine per cent of females with SI, vs a population frequency of 18 per cent. Among first degree relatives of probands with SI, radiologic changes were found no more frequently than in a randomly selected age matched control series. Uveitis occurred in 18 per cent of the B27 positive subjects, but in only five per cent of the B27 negative subjects (p less than 0.05). B27 was associated with SI and uveitis in Pima males, but no association was demonstrated between B27 and SI in Pima females.
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PMID:HLA B27 and sacroiliitis in Pima Indians--association in males only. 26 96

The families of 21 ankylosing spondylitis (AS) and 16 sacroiliitis (SI) patients were investigated and typed for HLA markers. The association of HLA B27 with AS was confirmed, but no strong evidence for the same or other HLA markers being associated with SI was found. Inheritance patterns in families were analyzed according to the multifactorial and monofactorial models. It is proposed that a major gene associated or interacting with the B27 product controls the susceptibility to AS, and that this gene behaves as a dominant with incomplete penetrance. The problem as to whether linkage disequilibrium maintained by selective pressure, or functional epistasis between the "disease gene" and the B27 antigen may be the acting mechanism of association, remains to be elucidated.
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PMID:Family studies and HLA typing in ankylosing spondylitis and sacroiliitis. 26 97

A series of 187 patients with definite ankylosing spondylitis was studied. Seventeen of these lacked the antigen HLA B27, but had signs and symptoms identical to the 170 HLA B27 positive patients. The study provides additional confirmation that other factors besides HLA B27 are involved in the development of ankylosing spondylitis.
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PMID:Ankylosing spondylitis without HLA B27. 26 98


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