Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UNIPROT:P01889 (
ankylosing spondylitis
)
5,717
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Misfolding of major histocompatibility complex (MHC) class I molecules has been implicated in the rheumatic autoimmune disease
ankylosing spondylitis
(AS), and has been linked to the unfolded protein response (UPR) in rodent AS models.
XBP1
and ATF6alpha are two important transcription factors that initiate and co-ordinate the UPR. Here we show that misoxidised MHC class I heavy chains activate
XBP1
processing in a similar manner to tunicamycin, with tunicamycin and dithiothreitol (DTT) inducing differential
XBP1
processing. Unexpectedly, ATF6alpha mRNA is alternatively spliced during reducing stress in lymphocytes. This shorter ATF6alpha message lacks exon 7 and may have a regulatory role in the UPR.
...
PMID:Activation of the unfolded protein response and alternative splicing of ATF6alpha in HLA-B27 positive lymphocytes. 1744 11
