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Query: UNIPROT:P01889 (ankylosing spondylitis)
 5,717 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Levels of immunoglobulins, alloantibodies and the presence of autoantibodies were prospectively studied during and after pregnancy in healthy women and in women suffering from rheumatoid arthritis (RA) and ankylosing spondylitis (AS). A decrease of IgG and IgA during pregnancy was found in all women while levels of IgM and alloantibodies remained stable. Multiparous women had higher levels of IgG during pregnancy when compared to primigravidae. No difference in the frequency of rheumatoid factor (RF) or antinuclear antibodies (ANA) was found when healthy pregnant women were compared to healthy non pregnant controls. None of the RF negative patients conversed to seropositivity during or after pregnancy. Decrease of ANA was correlated to remission of disease activity in the patients with RA.
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PMID:Studies on humoral immunity in pregnancy: immunoglobulins, alloantibodies and autoantibodies in healthy pregnant women and in pregnant women with rheumatoid disease. 660 63

The erythrocyte sedimentation rate (ESR) and the serum acute-phase proteins (APP), C-reactive protein (CRP), fibrinogen, 9th component of complement (C9), and alpha, antitrypsin were measured on 231 occasions in 80 patients with ankylosing spondylitis and compared with those in 30 controls. APP levels did not correlate with clinical assessment of disease activity. However, there were significant correlations between CRP, C9, and fibrinogen (p = less than 0.01), suggesting that these APP may be more reliable indicators of disease activity. The mean values of the APP in those patients with a peripheral arthritis were significantly higher than in those with pelvospondylitis alone for ESR (p less than 0.01), CRP (p less than 0.01), and fibrinogen (p less than 0.05). The only significant difference between those patients with an iritis and those with only pelvospondylitis was an elevated CRP in the iritis group (p less than 0.01). This suggests that a peripheral arthritis is the most important cause of an elevated ESR or APP in ankylosing spondylitis. Serum immunoglobulins were also measured and they showed a significant elevation of IgA in all 3 patients groups, there being no difference between each group. Serum IgG was raised only in those patients with an iritis or peripheral arthritis, the IgM levels being within the normal range for all patient groups.
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PMID:Acute-phase proteins and serum immunoglobulins in ankylosing spondylitis. 660 19

The concept of seronegative spondarthritis, linking several diseases around ankylosing spondylitis, has received considerable clinical and genetic support, especially through the discovery of a high frequency of HLA-B27 in these disorders. Exogenous factors would appear to be responsible for some manifestations of the disease, but the role of Klebsiella micro-organisms is equivocal, and dietary control does not affect clinical manifestations. Increased serum and salivary IgA antibodies in active ankylosing spondylitis patients tend to suggest that IgA may act as an acute-phase reactant.
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PMID:Pathogenesis of seronegative arthritis. 660 73

Total serum immunoglobulins and class specific serum antibodies to Klebsiella pneumoniae, Salmonella typhimurium, Yersinia enterocolitica and Pseudomonas aeruginosa were measured in 107 patients with ankylosing spondylitis (AS) and 110 healthy tissue typed controls by enzyme linked immunosorbent assay (ELISA). The specificity of this technique was confirmed by the use of specific bacterial murine antisera and by cross-absorption of human sera by specific bacteria. Total serum IgA in AS patients correlated with both erythrocyte sedimentation rate (ESR) (P less than 0.001) and C-reactive protein (P less than 0.05) and was significantly elevated compared to healthy individuals (P less than 0.001). A significant elevation of IgA antibodies to K. pneumoniae was detected in the serum of AS patients with active disease when compared to healthy controls (P less than 0.01). These studies support the involvement of an enterobacterial micro-organism in the pathogenesis of AS and further relate to the role of HLA-B27 in this disease.
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PMID:HLA-B27 and the immune response to enterobacterial antigens in ankylosing spondylitis. 660 43

Specific IgA antibodies were measured by ELISA against Klebsiella, E. coli and Candida antigens in five different groups: active ankylosing spondylitis (high ESR), inactive ankylosing spondylitis (normal ESR), healthy controls, psoriasis and rheumatoid arthritis. Elevated levels of IgA antibodies against Klebsiella were found only in active ankylosing spondylitis patients.
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PMID:Elisa studies in ankylosing spondylitis. 665 91

Yersinia enterocolitica is suspected of involvement in the aetiology of reactive arthritis and ankylosing spondylitis. Its two major outer membrane proteins are important targets for IgA and other protein A reactive immunoglobulins in the sera of some patients with these diseases.
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PMID:Antibodies against cell envelope antigens of Yersinia enterocolitica in reactive arthritis and ankylosing spondylitis. 665 95

Using an indirect immunoperoxidase technique we found the numbers of IgG-containing cells in the rectal lamina propria to be increased in patients with ankylosing spondylitis compared with controls, but not in patients with acute anterior uveitis or rheumatoid arthritis, or in the first-degree relatives of patients with ankylosing spondylitis. No differences between diagnostic groups were detected in the numbers of cells containing IgA, IgM, IgD, or IgE. The total numbers of plasma cells in the rectal lamina propria were not significantly increased. Similar increases of IgG-containing cells were not found in the duodenal lamina propria of patients with ankylosing spondylitis.
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PMID:Increased numbers of IgG-containing cells in rectal lamina propria of patients with ankylosing spondylitis. 671 91

Patients with ankylosing spondylitis were asked to follow a 'klebsiella exclusion diet' for 5 months of a 10-month study. The same percentage of faecal samples were positive for klebsiella whether the patients were on or off the experimental diet. The diet also failed to influence variability of klebsiella serotypes. We found no correlation between acquisition of klebsiella and deterioration of disease symptoms, as recorded by the patients. Furthermore, carriage of klebsiella did not correlate with any of the following parameters of disease activity measured in the outpatient clinic: morning stiffness, pain measured on a visual analogue scale, analgesic consumption, ESR, total serum IgA. We found no evidence, therefore, that faecal klebsiella is involved in disease exacerbations of ankylosing spondylitis.
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PMID:Attempt to modify klebsiella carriage in ankylosing spondylitic patients by diet: correlation of klebsiella carriage with disease activity. 671 92

We describe a patient with ankylosing spondylitis and psoriasis who was found to have IgA nephropathy in a solitary kidney. Renal biopsy demonstrated mesangial proliferation and interstitial nephritis with mesangial deposition of IgA. Although the renal disease and the rheumatic disease could have been present together by chance association, evidence is presented to suggest a possible common pathogenesis.
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PMID:IgA nephropathy in a patient with ankylosing spondylitis and a solitary kidney. 672 12

In order to explore the alteration in immunological function in patients with ankylosing spondylitis (AS), serum concentrations of IgG, IgA, IgM, C3 and C4, and lymphocyte subpopulations defined by monoclonal antibodies (OKT series) were studied in 40 AS and 20 age-matched normals. The results showed that i) The IgG and IgA in AS patients were much higher than those in normals (p less than 0.001) and C3, C4 and IgM were also increased (p less than 0.01, less than 0.05, less than 0.05, respectively), ii) The percentage of B cells and OKT3 cells of AS patients were lower, but OKT8 and OKIa1 were higher than that of normals (p less than 0.05). When the AS patients were further divided into active group (22 cases) with c-reaction protein (CRP) higher than, or equal to 15 mg/l and inactive group (18 cases) with CRP less than 15 mg/l, it was found that the inactive group had decreased B cells (p less than 0.01) and OKT3 (p less than 0.05) as compared with normals. On the other hand, the active group had increased percentage of OKT8 than normal controls (p less than 0.05), and increased OKIa1 than both inactive group and normal controls (p less than 0.01), but OKT3 decreased than the normal (p less than 0.05). It is therefore concluded that the immunological aberration plays a role in the pathogenesis of AS.
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PMID:Immunological aberrations in ankylosing spondylitis patients. 674 92


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