Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:P01889 (ankylosing spondylitis)
 5,717 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

HL-A27 were found in 31 of 48 patients with Reiter's disease (65%) as compared with 8% of 2 103 health controls. It is suggested that HL-A27 is closely related to the inheritance of a special immune response leading to an increased susceptibility to a special type of reactive arthritis which Reiter's disease has in common with ankylosing spondylitis and a certain type of psoriatic arthritis.
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PMID:Reiter's disease and the histocompatibility antigen, HL-A 27. 5 Jun 18

HL-A types were determined in 90 successive patients with non-granulomatous uveitis. Fifty-one were HL-A27 positive (55.7%) compared to 8.2% of controls. Of 16 patients with ankylosing spondylitis, 13 were HL-A27 positive, as were two patients with a history of Reiter's syndrome. Twenty-eight patients were HL-A27 positive but had no evidence of rheumatic disease. The findings are discussed in relation to the possible pathogenesis of uveitis.
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PMID:HL-A27 and anterior uveitis. 5 8

A family with high prevalence of ankylosing spondylitis (A.S.) was investigated for the presence of HL-A27. In this family, classical A.S. occurred in five subjects and possible A.S. in two out of 64 members examined. In all seven cases, HL-A27 was present. The study of the segregation of A.S. and HL-A27 in this kindred demonstrates that more than one gene is responsible for the expression of A.S., that the homozygous state for the HL-A27 gene may lead to the occurrence of A.S., and that possibly a simple genetic explanation accounts for the simultaneous transmission of HL-A27 and A.S.
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PMID:Segregation of HL-A27 and ankylosing spondylitis in an informative kindred. 12 85

A review of disorders with a known genetic basis which occur in orthopaedic practice is presented. Four groups of skeletal dysplasias are briefly described (short-limbed dwarfism, metaphyseal disorders, disorders of increased bone density and the storage diseases). Amongst the multifactorial defects, the aetiological relationship of congenital scoliosis with multiple vertebral anomalies to the neural tube defect is noted, as well as the high proportion of ankylosing spondylitis patients with HL-A27 antigen. A summary of current practice in antenatal diagnosis is given, including modern methods of detecting open neural tube defects by estimating alpha-fetoprotein.
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PMID:A review of genetics in orthopaedics. 80 81

A high association of HL-A27 specificity with ankylosing spondylitis was found in Japanese patients in spite of a very low frequency of this specificity in a normal Japanese population. These findings coincide well with those in Caucasian patients, and indicate the strong relationship between the susceptibility to ankylosing spondylitis and HL-A27 specificity beyond racial differences. No particular HL-A patterns were noted in patients with the ossification of the posterior longitudinal ligament of the cervical vertebrae. This observation provides an evidence that this disease is etiologically different from ankylosing spondylitis.
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PMID:Human lymphocyte antigen, HL-A27, in Japanese patients with ankylosing spondylitis. 112 50

In a kindred of 66 members spanning four generations, seven cases of ankylosing spondylitis (AS) HAVE BEEN FOUND. Four of these were in a single sibship of 13. AS was associated with HL-A27 in three of the four involved siblings, but close linkage was shown to be unlikely. Knowledge of HL-A genotype has made possible informed counseling for younger members of the sibship of 13, some of whom, as teenagers, already have back pain.
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PMID:Ankylosing spondylitis in a large kindred: clinical and genetic studies. 113 63

In patients with recent inflammatory arthritis HL-A27 was seen in 6 out of 7 patients with ankylosing spondylitis, in 15 out of 18 patients with Reiter's disease, in 9 out of 12 patients with reactive postinfectious arthritis, in 22 out of 45 patients with rheumatoid arthritis, and in 2 out of 14 patients with other types of inflammatory arthritis. In two control series HL-A27 occurred in 46 out of 326 persons and in 3 out of 34 persons. The high frequency of HL-A27 in RA patients is in disagreement with previous results by other investigators. The explanation for this may be either that the diagnostic criteria do not apply at the early stage of the disease, or that there is a high prevalence of HL-A27 associated RA in Finland.
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PMID:HL-A27 and arthritis. 119 Jun 99