Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:P01889 (ankylosing spondylitis)
 5,717 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Albuminemia, calcemia, phosphoremia and alcaline phosphatasemia were measured in three groups of 52 subjects each : rheumatoid arthrits, inflammatory rheumatisms other than rheumatoid arthritis and lumbarthrosics serving as a reference group. Calcemia and albuminemia were significantly lower in patients suffering from rheumatoid arthritis, whose calcemia corrected in relation to albuminemia is, on the other hand, normal : the increase in corrected calcemia pointed out by Kennedy, was not noted. Corrected calcemia was also normal in ankylosing spondylitis, but it was significantly higher in polymyalgia rheumatica. Phosphoremia was shown to be normal but alkaline phosphatases were higher than normal in the three groups.
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PMID:[Changes in blood calcium, phosphorus and alkaline phosphatase levels in rheumatoid polyarthritis and other types of inflammatory rheumatism]. 31 11

The sera of 161 subjects hospitalized in a rheumatology department were tested for anti-IgG antibodies using a "PEG radioimmunoprecipitation assay" (RIPEGA), for circulating immune complexes using the liaison test with Clq 125I, and dosage of complement and its metabolites. No significant difference was found between the group of 37 ankylosing spondylitis and the group of 44 control subjects. The results were identical, whatever the form of the disease, be it peripheral or central, and evolutive or non evolutive. On the contrary, the study of the rheumatoid arthritis (47 seropositive and 34 seronegative) provided results in conformity to previous works. The different physiopathogenic origin of these two chronic inflammatory rheumatisms is discussed by the authors.
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PMID:[Absence of circulating immune complexes and of serum anti-IgG antibodies during ankylosing spondylarthritis]. 31 12

The authors characterize the position which developed in the sphere of rheumatic diseases, in particular inflammatory ones, after in these diseases the association with HLA antigens was revealed; most important is still the association of HLA B 27 with ankylosing spondylitis (Bekhterev's disease) which stimulated a new line of research and helped to detect the projection of antigen into all so-called rheumatic diseases which have in addition to affected peripheral joints inflammatory change of the SI synchrondrosis and segmentary signs of ankylosing spondylitis. The authors examined patients with psoriatic arthropathy and pure dermatological psoriasis but found only association with B 17 and B 13. In ankylosing hyperotosis (Forestier) they prove, based on the findings in 36 patients that in controversial cases the absence of B 27 may be important. They report also on their finding of an enhanced association of A 10 and B 14 in a group of 48 patients with seropositive rheumatoid arthritis.
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PMID:Hitherto assembled results with the assessment of HLA antigens in rheumatic diseases and their impact. 31 61

Granulocyte-specific antinuclear antibodies (GS-ANA) were detected in the sera of 5 of 88 patients with ankylosing spondylitis (AS) and in 7 of 52 cases of psoriatic arthritis (PsA), but were not found in 91 patients with malignant or non-malignant chest disease nor in 25 cases of psoriasis. Organ non-specific ANA were present in serum from 6 cases of AS and 1 of PsA. None of the sera gave significant levels for soluble immune complexes as detected by a C1q-binding assay. The presence of antinuclear antibodies was not associated with clinical features or drug therapy in either AS or PsA.
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PMID:Antinuclear antibodies in ankylosing spondylitis, psoriatic arthritis, and psoriasis. 31 36

Fenoprofen1 (dl-2-[3-phenoxyphenyl]propionic acid) is a new non-steroidal anti-inflammatory, antipyretic, analgesic agent advocated for use in rheumatoid arthritis, degenerative joint disease, ankylosing spondylitis and gout. Published data suggest that in rheumatoid arthritis, fenoprofen 2.4 g daily is comparable in effectiveness with moderate doses of aspirin (3.6 to 4 g daily), but generally causes fewer and milder side-effects at the dosages used. In published comparisons with other non-steroidal anti-inflammatory agents of the same chemical group, it is closely comparable with naproxen in effectiveness but tends to cause more minor side-effects than naproxen. However, as no one of the non-steroidal anti-inflammatory agents is the most suitable drug for all patients requiring such therapy, fenoprofen should be considered along with the other drugs of its type in the initial treatment of the arthritic patient. Fenoprofen has compared favourably with phenylbutazone in osteoarthrosis of the hips and with aspirin in osteoarthrosis of the shoulders, hips, knees and spine. Its exact place in the management of gout and ankylosing spondylitis remains to be determined.
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PMID:Fenoprofen: a review of its pharmacological properties and therapeutic efficacy in rheumatic diseases. 32 48

Flurbiprofen (150-200 mg daily) and phenylbutazone (300-400 mg daily) were compared in the management of 27 patients with active ankylosing spondylitis. This was a parallel, double-blind, and randomized trial of 6 weeks duration. Both drugs were equally effective in the relief of pain and tenderness of the affected joints. Overall subjective improvement, assessed by the patient and the investigator at the end of the trial, favored phenylbutazone, but it did not reach a statistically significant level. The mean values of the endpoint parameters of spinal motion showed statistically significant improvement in both groups, except in the Schober test in the flurbiprofen group and chest expansion in the phenylbutazone group. Untoward effects characteristic of these drugs were found in a few patients.
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PMID:Treatment of ankylosing spondylitis with flurbiprofen or phenylbutazone. 32 73

Immune function has been evaluated in 54 patients with ankylosing spondylitis (AS) and 26 controls. Cell-mediated immunity was assessed by skin testing with ubiquitous antigens, and humoral immunity by antibody responses to tetanus toxoid and Salmonella typhi vaccinations, and resting titres of anti-Streptolysin O, anti-E Coli, and isohemagglutinins. The AS patients had reduced delayed hypersensitivity responses to Candida, augmented responses to Streptococcal antigen and relatively low ASO titres. There was no generalized depression of humoral immunity, as indicated by the normal tetanus and Salmonella O responses and hyper-response to Salmonella H antigen. The E. Coli and isohemagglutinin titres were normal. These results indicate that patients with AS present a complex immunological profile, including exaggerated responses to some antigens and impaired responses to others. In view of the very high incidence of HLA-B27 in AS, it is possible that these findings are related to the effects of HLA associated immune response genes.
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PMID:Immune function in ankylosing spondylitis: apparent relationship between streptococcal responses and HLA B27. 32 6

Mononuclear cells infiltrating synovial membranes in chronic synovitis were characterised both in situ and in cell suspensions by surface markers and histochemical techniques. T-lymphocytes were the predominant infiltrating cell in rheumatoid arthritis as well as in other forms of chronic arthritis, including ankylosing spondylitis and arthritis associated with Crohn's disease. B-lymphocytes were found exclusively in rheumatoid synovial membranes. These cells were demonstrable both in true germinal centres and, focally and diffusely, in nodular mononuclear infiltrates lacking the histochemical characteristics of germinal centres. The synovial lining cells, unlike mononuclear phagocytes, had no demonstrable receptors for C3 and Fc.
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PMID:Characteristics of mononuclear cell populations in chronically inflamed synovial membranes. 32 37

Immunofluorescent studies were conducted for leukocyte-reactive antinuclear antibody (LR-ANA) with sera from 125 patients with ankylosing spondylitis (as), 124 with rheumatoid arthritis (RA) 74 with miscellaneous immune disorders (MID), 34 with acute inflammatory disorders (AID) and 122 non-immune controls. Positive reactions occurred with 60% of AS patients, 47% of RA, 40% of MID, 12% of AID, and 9% of non-immune controls. LR-ANA in AS sera invariably showed a homogeneous pattern of immunofluorescent staining with human granulocytes, occasionally reacted with human lymphocytes but did not react with other human and non-human substrates. Studies of 61 members of seven families with 18 cases of AS revealed a frequency of 38% LR-ANA, 30% AS and 55% HLA-B27, but no correlations were found among these parameters. These studies provide evidence of altered humoral immunity to human nucleic acids in the majority of patients with AS.
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PMID:Increased frequency of leukocyte-reactive antinuclear antibody in patients with ankylosing spondylitis. 32 81

The effects of flurbiprofen (150-200 mg daily) and indomethacin (75-100 mg daily) were compared in the management of 26 patients with active ankylosing spondylitis in a parallel, double-blind, and randomized trial of six weeks' duration. No patient in either group withdrew from the study because of lack of efficacy of the drugs. Both drugs were equally effectivein relieving the pain and tenderness of the affected joints. Overall subjective improvement, assessed by the patient and the investigator at the end of the trial, was present in 90% of the patients in the flurbiprofen group and in 75% of the indomethacin group. The mean values of all the spinal motion tests improved in the flurbiprofen group but not in the indomethacin group. Statistically significant improvement of the Schober test was achieved in the flurbiprofen group and of the chest expansion measurement in the indomethacin group. Untoward effects related to the central nervous system and gastrointestinal tract were present in a few patients in both groups.
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PMID:Management of ankylosing spondylitis with flurbiprofen or indomethacin. 32 22


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