Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:P01889 (ankylosing spondylitis)
 5,717 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A family with high prevalence of ankylosing spondylitis (A.S.) was investigated for the presence of HL-A27. In this family, classical A.S. occurred in five subjects and possible A.S. in two out of 64 members examined. In all seven cases, HL-A27 was present. The study of the segregation of A.S. and HL-A27 in this kindred demonstrates that more than one gene is responsible for the expression of A.S., that the homozygous state for the HL-A27 gene may lead to the occurrence of A.S., and that possibly a simple genetic explanation accounts for the simultaneous transmission of HL-A27 and A.S.
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PMID:Segregation of HL-A27 and ankylosing spondylitis in an informative kindred. 12 85

The mixed lymphocyte reaction against a pool of blocked lymphocytes was studied in individuals with and without HL-A 27, including controls, spouses, parents, sibs, and offspring, and patients with ankylosing spondylitis. In controls without HL-A 27 the mean increment of counts perminute was 46,630 compared with 29,860 in asymptomatic controls and relatives with HL-A 27 and 26,277 in spondylitic patients with HL-A 27. The mean response was also reduced to 34,902 in sibs and offspring without HL-A 27, and to 20,916 in three patients with spondylitis in the absence of HL-A 27.
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PMID:Diminished mixed lymphocyte reaction in ankylosing spondylitis, relatives, and normal individuals all with HL-A 27. 13 44

The HL-A system is part of the main histocompatibility complex of man which is located on chromosome A6. The clinical importance of this antigen system lies in its application in the immunological choice of donor for transplantations, it being clear that still other important transplantation systems must be located on chromosome 6. The fact that in many diseases certain HL-A antigens occur more frequently has acquired a certain diagnostic significance in ankylosing spondylitis, iritis and juvenile rheumatoid arthritis. The associations with HL-A observed can best be explained by the assumption HL-A-coupled defective immunoresponse genes which are partly responsible for sensitivity to disease.
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PMID:[The clinical importance of tissue antigens (HL-A) in man (author's transl)]. 13 9

Highly significant improvement of symptoms was found during treatment with clofezone (Perclusone) over a period of 4 weeks in 56 in-patients with various rheumatic diseases, particularly rheumatoid arthritis (RA), ankylosing spondylitis (AS), and lumbar and cervical syndromes. During the first week clofezone was given at a daily dosage of 1200 mg and thereafter 600 mg. At the same time 21 of the patients with RA and 13 with AS received ACTH injections (0.25 mg twice a week). Already after the first week of treatment a highly significant decrease of disease activity was noticed, as judged by the amount of pain, inhibition of movements, joint swelling and erythrocyte sedimentation rate. The latter decreased on an average by 50% during the treatment period indicating a reduction of the inflammatory process. 51 of the 56 patients showed a satisfactory to very good tolerance of the treatment. Clofezone was discontinued in 5 patients during the first week, because gastro-intestinal intolerance occurred with the 1200 mg dosage. One of these 5 patients tolerated the smaller dosage later. As 3 of the 5 patients belonged to the RA and AS groups, the ACTH administration also has to be considered with regards to the intolerance. Because of possible side effects the higher dosage of clofezone should be given as short term treatment of highly active disease processes only. Clofezone reduced the serum uric acid level in 38 of 45 patients. Pathologically increased levels were reduced to normal in 15 of 17 patients.
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PMID:[Experiences in the management of rheumatoid diseases using different clofezone doses]. 13 65

A controlled study of 138 subjects demonstrated that the clinical history may be sensitive (95%) and specific (85%) in the differential diagnosis of ankylosing spondylitis when reliance of five specific historic features is made. Back pain that is insidious in onset, in a patient younger than 40 years, persisting for at least three months, associated with morning stiffness and improving with exercise is characteristic of inflammatory spinal disease.
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PMID:Clinical history as a screening test for ankylosing spondylitis. 14 Feb 52

By typing of 90 patients with ocular pathology (uveitis, diseases of optic nerve, Eale's disease, pseudo-tumor cerebri) the authors have found a constant and significant increase in the frequency of H.L.A. A2 especially in uveitis by streptococcus. However, a frequency of H.L.A. B27 as elevated as in previous publications was not found--but the parallelism: H.L.A. B27--ankylosing spondylitis was always found. Finally, the authors emphasized the haplotype H.L.A. A2 H.L.A. B5 in two cases of pseudo-tumor cerebri.
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PMID:[Tissue groups and ophthalmology]. 14 Jun 45

In serum samples from 37 patients with ankylosing spondylitis (AS), immune complexes were quantitated by the 125I-Clq binding test; in paired plasma samples the C3 breakdown product C3d was measured by an immunochemical method. Compared to results in 30 blood donors, the Clq binding activity was significantly (greater than 2 SD), although discretely, increased in 5 of 8 patients with seropositive AS, but not in other AS patients. All C3d levels were within the normal range. In a parallel investigation, increased Clq binding activity and C3d levels were found in 87% and 90%, respectively, of patients with seropositive rheumatoid arthritis.
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PMID:Immune complexes and complement catabolism in ankylosing spondylitis. 14 Jun 91

In order to determine the prevalence of ankylosing spondylitis and the prevalence and pattern of back pain amongst the relatives of patients with ankylosing spondylitis, 63 first degree relatives of 14 propositi were assessed by means of questionnaire, physical examination, and radiology. There were no significant differences in the responses of the B27 positive and negative relatives in relation to prevalence, severity and character of back pain. Ankylosing spondylitis was found in 6.5 per cent of B27 positive relatives and 3.1 per cent of B27 negative relatives; sacroilitis being present in 12.9 per cent of B27 positive relatives and 6.3 per cent of B27 negative relatives. A family studied is presented as a possible corssover between HLA B locus and disease "predisposition" genes. It is suggested patterns of back pain may not be as discriminating as has been thought.
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PMID:Symptoms and signs among relatives of patients with HLA B27 ankylosing spondylitis: Correlation between back pain, spinal movement, sacroilitis, and HLA antigens. 14 Sep 34

Pyogenic disc space infection is a rare and unappreciated cause of low back pain. Reported herein is a young man with chronic low back pain and the HLA-B27 antigen which initially led to the diagnosis of ankylosing spondylitis. However, serial lumbar radiographs and bone scan established an inflammatory lesion involving the L2-L3 intervertebral disc space, and persistently normal sacroiliac joints. A needle biopsy and culture of the disc space yielded Staphylococuss aureus. Treatment with antibiotics, bed rest and back bracing resulted in a complete resolution of symptoms and healing of the vertebral lesion. It is the purpose of this report to review the clinical, laboratory and radiographic features of intervertebral disc space infection as well as pitfalls in its diagnosis.
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PMID:Intervertebral disc space infection: another low back syndrome of the young. 14 38

The radiological criteria of juvenile, rheumatic, cervical synostosis discovered in adult life are described and illustrated. These include: involvement of few or many segments, a tendency to bony ankylosis of the diseased intervertebral joints, dysplasias or hypoplasia of the vertebral body and intervertebral disc and dysplasias of the neural arches and hypoplasia of the transverse processes. Pathological ossification may involve the ligamentum flavum, the annulus, or the entire disc. The differential diagnosis of juvenile, rheumatic, cervical synostosis includes congenital block vertebrae, Klippel-Feil syndrome, acquired block vertebrae, juvenile ankylosing spondylitis, synostosing, intervertebral osteochondrosis and myositis ossificans progressiva.
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PMID:[The radiogical criteria of juvenile rheumatic cerivical synostosis in adults (author's transl)]. 14 15


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