Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:P01889 (ankylosing spondylitis)
 5,717 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Klebsiella pneumonia (KP) infection and HLA-B 27 have been shown to be strongly associated with ankylosing spondylitis (AS). In the present study, faecal cultures were performed and showed faecal carriage rate of KP was much higher in patients with AS (10/30) and hospital volunteers (2/10) than in the non-hospital volunteers (0/20). An octadecapeptide encompassing the shared hexamer between HLA-B 27 and KP nitrogenase residue was synthesized and autoantibodies against this short peptide were detected in sera of patients with AS and Reiter's syndrome (RS) and other related disease and normal controls. The results showed that such autoantibodies were detected in 42.2% of AS and 30% of RS patients yielding positive rate much higher than those found in other control groups. It is concluded that enteric KP infection were strongly implicated in the pathogenesis of AS probably by the mechanism of molecular mimicry with HLA-B 27.
Zhonghua Nei Ke Za Zhi 1992 Jul
PMID:[Role of enteric Klebsiella pneumonia infection and HLA-B27 in ankylosing spondylitis]. 129 92

The diagnosis of JAS in 19 of the 24 patients with oligo-articular and the polyarticular subtypes of JRA established primarily was reexamined. Coexistence of JAS and rheumatoid arthritis was found in 4 of the 19 patients with JAS. Of the 19 patients with JAS, 18 were male and 1 was female. The mean age of onset of the disease was 12.6 years (ranging from 8 to 16). Peripheral arthritis was the first symptom in all the 19 patients, predominantly in the joints of knee, hip and ankle. 69% of the 13 patients with hip involvement developed deformity. Twelve patients had lumbosacral pain. Arthritis occurred in 7 of the 19. There was X-ray evidence of sacroilitis in all the JAS patients. In 3 of the 19 patients' families, all the family members had ankylosing spondylitis. Laboratory investigations confirmed the presence of HLA-B27 and absence of RF and ANA in these 19 patients. The study shows that early findings of JAS are not easy to distinguish from those of JRA and that the diagnosis of JAS should be considered for a boy of teenage with chronic arthritis.
Zhonghua Nei Ke Za Zhi 1990 Dec
PMID:[Juvenile ankylosing spondylitis (JAS) and juvenile rheumatoid arthritis (JRA)]. 209 54

This study was performed in order to probe the possible pathogenesis of Klebsiella pneumoniae (KP) in ankylosing spondylitis (AS). 34 anti-KP antibody positive serum samples, including 26 patients with AS, 5 patients with rheumatoid arthritis (RA) and 2 healthy individuals, were selected to detect anti-subtypical KP antibodies by using an immunoblotting technique. The results showed that the number of antigenic bands to KP on nitrocellulose membrane was higher in AS patients than in RA patients and healthy individuals. Patients with AS had common antibodies response to KP components weight 64,600 (80.7%), 48,200 (61.5%) and 36,000 (65.4%), patients with RA and healthy individuals had anti-36,000 (75%) and anti-30,000 (50%) antibodies. Human anti-HLA-B27 serum and rabbit antisera against KP-derived synthetic peptide containing the hexapeptide sequence shared by HLA-B27 were able to cross react with 64,600 and 48,200 KP components. Our findings suggest that KP might play a role in the pathogenesis of AS by molecular mimicry between it and HLA-B27.
Zhonghua Nei Ke Za Zhi 1995 Mar
PMID:[Serum anti-subtypical Klebsiella pneumoniae antibodies in ankylosing spondylitis]. 764 43

By use of low molecular weight polyethlene glycol (PEG400) as tracer, a revised Chedwick method with capillary gas chromatography was used to examine the intestinal permeability in 49 subjects including patients with ankylosing spondylitis (AS) and rheumatoid arthritis (RA) and healthy controls. Recovery percentage, maximal recovery percentage [Rmax(%)] and Rmax(w) were used to find the effect of bowel permeability in the pathogenesis and disease flare up of AS, as well as the role of HLA-B27 for the bowel permeability. The results showed that in AS group, the recovery of first component (242D) was higher and the Rmax(%) was lower than those in the controls. No statistical difference was found with other indexes. The results indicated that bowel permeability is not elevated in AS. The passage of enteral bacteria antigen into the host may not result from the process of nonspecific penetration. We postulate that there may somehow be a process of "active transportation" in the pathogenesis of AS. More studies of the process are necessary to clarify its importance in the early stage of AS.
Zhonghua Nei Ke Za Zhi 1995 Feb
PMID:[The role of intestinal permeability in the pathogenesis of ankylosing spondylitis]. 779 64

Serum anti-total and subtypical histone antibodies were detected with ELISA and Western-Blotting in 78 ankylosing spondylitis (AS) and 38 gouty arthritis (GA) patients as well as in 45 normal subjects. The results showed that the positive rate of anti-histone antibodies (AHA) was about 5% in normal subjects or GA patients and 24.4% in AS patients. The mean level of AHAs was much higher in AS group than those in the controls. IgG- and IgM-AHA levels in AS patients during active stage were higher than in those during inactive stage. AHA levels were much more elevated in AS patients with present illness or past history of uveitis than in those without. The high levels of AHAs (especially anti-H3 antibody) were associated with uveitis in AS patients. The results suggested that the high level of AHAs might be a monitoring parameter for disease activity and occurrence of uveitis in patients with AS.
Zhonghua Nei Ke Za Zhi 1994 Jun
PMID:[Detection of serum anti-histone antibodies in patients with ankylosing spondylitis and its clinical significance]. 786 27

This study was performed to evaluate the involvement of Klebsiella pneumoniae (Kp) in ankylosing spondylitis. Serum IgA, IgG and IgM antibodies to Kp were measured with ELISA in 60 patients with ankylosing spondylitis (AS), 28 patients with rheumatoid arthritis (RA) and 45 healthy individuals. A marked elevation of IgA antibody to Kp was detected in the sera of patients with AS, compared to that in patients with RA (P < 0.02) and healthy controls (P < 0.001). The positive rate of antibodies to Kp was 55% in patients with active AS, significantly higher than that in patients with inactive AS (16.7%, P < 0.01), patients with RA (17.8%, P < 0.05) and healthy controls (4.4%, P < 0.001). Stool culture for Kp was carried out in 15 of the 60 patients with AS simultaneously, 3 (20%) of them were positive. Our results are in line with the previously published findings suggesting that Kp may play a role in the pathogenesis of AS.
Zhonghua Nei Ke Za Zhi 1993 Jul
PMID:[Antibodies to Klebsiella pneumoniae in ankylosing spondylitis]. 827 26

22,049 adults were surveyed in a ten-year epidemiological study. The frequency of common rheumatic symptoms in Shantou population was much lower than that in northern China. The prevalence of ankylosing spondylitis, rheumatoid arthritis, osteoarthritis, osteoporosis and gout was 0.20%-0.32%, 0.20%-0.26%, 8.3%-10.8%, 12.4% and 0.15%-0.17% respectively. The frequency of HLA-B27 was 4.1% among general population and 90.6% in ankylosing spondylitis. The most commonly involved sites of osteoarthritis were lumbar spine, neck, and knee; but hands and hip were rarely involved. 85% subjects under investigation were found to be short of calcium intake. The differences between the north and the south of China in the prevalence of rheumatic symptoms may be related to the diversities in consciousness of seeking medical advice, reduction of bone content, climate and ergonomics.
Zhonghua Nei Ke Za Zhi 1997 Mar
PMID:[10-year epidemiological study on rheumatic diseases in Shantou area]. 1037 16