Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:P01889 (ankylosing spondylitis)
 5,717 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The radiological changes of the cervical spine were evaluated in 57 patients with psoriatic arthritis and were correlated with clinical, radiological, and immunogenetic features of the disease. Forty patients (70%) showed radiological evidence of the cervical spine being affected by the disease. Two patterns of cervical spine abnormalities were noted. Fifteen patients (26%) had erosive and/or subluxing cervical rheumatoid like lesions; 25 patients (44%) had a more frequently reported pattern similar to ankylosing spondylitis. Although subaxial subluxations were the most frequently observed cervical abnormalities (53%) in the inflammatory subgroup, none of the patients studied had cord compression. Ankylosing cervical spine disease was the only form of axial involvement in nine (36%) of 25 patients with the ankylosing form of psoriatic arthritis. All of these patients had peripheral disease and were B27 negative. Predictors of cervical spine disease patterns were considered using clinical, demographic, and radiological features and HLA antigens. The results of a multivariate analysis showed that the best predictors of inflammatory cervical spine disease are the presence of HLA-B39 and HLA-DR4 antigens, radiocarpal erosions, and the absence of the HLA-DR5 antigen.
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PMID:The cervical spine in patients with psoriatic arthritis: a clinical, radiological and immunogenetic study. 154 41

A possible association between ankylosing spondylitis (AS) and multiple sclerosis (MS) has been suggested in whites. The authors describe the first report of the coexistence of AS and MS in a black patient. The clinical diagnosis of MS was further substantiated by the results of magnetic resonance imaging of the brain. The diagnosis of AS met the Rome as well as the New York criteria. The patient possessed HLA-B27; his complete HLA phenotype was Aw66, B27, Cw2, DR3, and DR5.
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PMID:Unusual occurrence of ankylosing spondylitis and multiple sclerosis in a black patient. 260 79

We attempted to clarify the association between HLA and Crohn's disease. HLA-A, -B, -C and -DR locus antigens in 62 Japanese patients with Crohn's disease were analyzed and the results were compared with findings of 231 healthy Japanese. In the patients with Crohn's disease there was a strong association with HLA-DR4 and -DR5 (chi2 = 14 . 013, RR = 4 . 77 and chi2 = 9 . 345, RR = 5 . 04) and a weak association with HLA-Bw46 and -Bw51 (chi2 = 7 . 077, RR = 2 . 63, and chi2 = 5 . 401, RR = 2 . 52). There was a close association between HLA-DR5 in those with the ileocaecal type, and the -Bw51 and small intestine type. Therefore susceptibility to Crohn's disease may relate to specific allotypes on the human major histocompatibility complex. The correlation was weaker than the other diseases such as ankylosing spondylitis and Coeliac disease.
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PMID:Immunological studies in Crohn's disease. I. Association with HLA systems in the Japanese. 661 20